| Full name: leucine rich repeat containing 18 | Alias Symbol: UNQ933|MGC34773|UNQ9338|VKGE9338 | ||
| Type: protein-coding gene | Cytoband: 10q11.23 | ||
| Entrez ID: 474354 | HGNC ID: HGNC:23199 | Ensembl Gene: ENSG00000165383 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of LRRC18:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LRRC18 | 474354 | 1554331_a_at | -0.0032 | 0.9918 | |
| GSE26886 | LRRC18 | 474354 | 1554331_a_at | 0.0645 | 0.6180 | |
| GSE45670 | LRRC18 | 474354 | 1554331_a_at | 0.0074 | 0.9397 | |
| GSE53622 | LRRC18 | 474354 | 54933 | 0.2767 | 0.0422 | |
| GSE53624 | LRRC18 | 474354 | 54933 | 0.0343 | 0.8346 | |
| GSE63941 | LRRC18 | 474354 | 1554331_a_at | 0.2157 | 0.0653 | |
| GSE77861 | LRRC18 | 474354 | 1554331_a_at | -0.0428 | 0.5483 | |
| GSE97050 | LRRC18 | 474354 | A_24_P321125 | -0.0303 | 0.9335 | |
| SRP133303 | LRRC18 | 474354 | RNAseq | -0.7097 | 0.0017 | |
| TCGA | LRRC18 | 474354 | RNAseq | -1.4146 | 0.1547 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by LRRC18 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LRRC18:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LRRC18 | 474354 | 2 | 5 | 23 | |
| GSE20123 | LRRC18 | 474354 | 2 | 5 | 23 | |
| GSE43470 | LRRC18 | 474354 | 2 | 6 | 35 | |
| GSE46452 | LRRC18 | 474354 | 0 | 13 | 46 | |
| GSE47630 | LRRC18 | 474354 | 4 | 12 | 24 | |
| GSE54993 | LRRC18 | 474354 | 9 | 0 | 61 | |
| GSE54994 | LRRC18 | 474354 | 2 | 10 | 41 | |
| GSE60625 | LRRC18 | 474354 | 0 | 0 | 11 | |
| GSE74703 | LRRC18 | 474354 | 2 | 3 | 31 | |
| GSE74704 | LRRC18 | 474354 | 1 | 4 | 15 | |
| TCGA | LRRC18 | 474354 | 12 | 22 | 62 |
Total number of gains: 36; Total number of losses: 80; Total Number of normals: 372.
Somatic mutations of LRRC18:
Generating mutation plots.
Highly correlated genes for LRRC18:
Showing top 20/98 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LRRC18 | ANKRD53 | 0.730934 | 3 | 0 | 3 |
| LRRC18 | DKKL1 | 0.713388 | 3 | 0 | 3 |
| LRRC18 | B3GALT1 | 0.712272 | 3 | 0 | 3 |
| LRRC18 | NXPH3 | 0.686522 | 4 | 0 | 4 |
| LRRC18 | PENK | 0.669691 | 3 | 0 | 3 |
| LRRC18 | TMEM184A | 0.664882 | 3 | 0 | 3 |
| LRRC18 | AANAT | 0.660585 | 3 | 0 | 3 |
| LRRC18 | CELA3B | 0.660205 | 4 | 0 | 4 |
| LRRC18 | PLA2G4F | 0.64864 | 3 | 0 | 3 |
| LRRC18 | TMEM102 | 0.646546 | 3 | 0 | 3 |
| LRRC18 | RAD51D | 0.642362 | 4 | 0 | 3 |
| LRRC18 | AVPR1B | 0.64052 | 3 | 0 | 3 |
| LRRC18 | RNF41 | 0.639167 | 3 | 0 | 3 |
| LRRC18 | RSPH6A | 0.635764 | 3 | 0 | 3 |
| LRRC18 | DPP6 | 0.63557 | 4 | 0 | 3 |
| LRRC18 | FBP2 | 0.634974 | 3 | 0 | 3 |
| LRRC18 | ARHGEF38 | 0.634005 | 3 | 0 | 3 |
| LRRC18 | HCRT | 0.628136 | 4 | 0 | 3 |
| LRRC18 | GPD1 | 0.623365 | 3 | 0 | 3 |
| LRRC18 | REN | 0.623226 | 4 | 0 | 3 |
For details and further investigation, click here
