POLR2H

 

Full name: RNA polymerase II subunit H Alias Symbol: RPB8
Type: protein-coding gene Cytoband: 3q27.1
Entrez ID: 5437 HGNC ID: HGNC:9195 Ensembl Gene: ENSG00000163882 OMIM ID: 606023
Drug and gene relationship at DGIdb

 

Expression of POLR2H:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 POLR2H 5437 209302_at 0.7982 0.0368
GSE20347 POLR2H 5437 209302_at 1.0842 0.0000
GSE23400 POLR2H 5437 209302_at 0.8679 0.0000
GSE26886 POLR2H 5437 209302_at 0.7601 0.0001
GSE29001 POLR2H 5437 209302_at 0.8823 0.0028
GSE38129 POLR2H 5437 209302_at 1.1847 0.0000
GSE45670 POLR2H 5437 209302_at 0.7901 0.0005
GSE53622 POLR2H 5437 8690 0.9133 0.0000
GSE53624 POLR2H 5437 8690 1.0641 0.0000
GSE63941 POLR2H 5437 209302_at 1.5917 0.0006
GSE77861 POLR2H 5437 209302_at 0.8840 0.0028
GSE97050 POLR2H 5437 A_33_P3396459 0.2702 0.2268
SRP007169 POLR2H 5437 RNAseq 1.6650 0.0022
SRP008496 POLR2H 5437 RNAseq 1.5725 0.0000
SRP064894 POLR2H 5437 RNAseq 1.2524 0.0000
SRP133303 POLR2H 5437 RNAseq 1.0744 0.0000
SRP159526 POLR2H 5437 RNAseq 1.3904 0.0000
SRP193095 POLR2H 5437 RNAseq 0.7455 0.0000
SRP219564 POLR2H 5437 RNAseq 0.4973 0.1188
TCGA POLR2H 5437 RNAseq 0.2828 0.0000

Upregulated datasets: 9; Downregulated datasets: 0.  

 

Survival by POLR2H expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of POLR2H:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 POLR2H 5437 25 0 5
GSE20123 POLR2H 5437 25 0 5
GSE43470 POLR2H 5437 25 0 18
GSE46452 POLR2H 5437 19 1 39
GSE47630 POLR2H 5437 27 2 11
GSE54993 POLR2H 5437 1 19 50
GSE54994 POLR2H 5437 41 0 12
GSE60625 POLR2H 5437 0 6 5
GSE74703 POLR2H 5437 21 0 15
GSE74704 POLR2H 5437 17 0 3
TCGA POLR2H 5437 77 0 19

Total number of gains: 278; Total number of losses: 28; Total Number of normals: 182.  

 

Somatic mutations of POLR2H:

 

Generating mutation plots.

 

Highly correlated genes for POLR2H:

 

Showing top 20/1737 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
POLR2HRFC40.81581413013
POLR2HACTL6A0.77950213013
POLR2HU2SURP0.770965909
POLR2HMCM20.76390312011
POLR2HPARL0.76292513012
POLR2HMAP3K130.762145807
POLR2HPSMD20.76140813012
POLR2HSNRPG0.75947211010
POLR2HBID0.75685510010
POLR2HLSG10.75682612012
POLR2HRUVBL10.75357912011
POLR2HTBCCD10.75293910010
POLR2HKIF4A0.74596810010
POLR2HPLXNA10.74446711010
POLR2HCKS1B0.74020812012
POLR2HALG30.74013913011
POLR2HECT20.73652912010
POLR2HMLF10.73608110010
POLR2HMYBL20.73591612011
POLR2HGMPS0.73582513011

For details and further investigation, click here