| Full name: LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated | Alias Symbol: YLR438C|SMX4|USS2 | ||
| Type: protein-coding gene | Cytoband: 3p25.1 | ||
| Entrez ID: 27258 | HGNC ID: HGNC:17874 | Ensembl Gene: ENSG00000170860 | OMIM ID: 607283 |
| Drug and gene relationship at DGIdb | |||
Expression of LSM3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LSM3 | 27258 | 202209_at | -0.2616 | 0.3012 | |
| GSE20347 | LSM3 | 27258 | 202209_at | -0.1770 | 0.3867 | |
| GSE23400 | LSM3 | 27258 | 202209_at | 0.0069 | 0.9124 | |
| GSE26886 | LSM3 | 27258 | 202209_at | -0.4628 | 0.0023 | |
| GSE29001 | LSM3 | 27258 | 202209_at | -0.1478 | 0.6910 | |
| GSE38129 | LSM3 | 27258 | 202209_at | -0.1801 | 0.1732 | |
| GSE45670 | LSM3 | 27258 | 202209_at | -0.1268 | 0.2275 | |
| GSE53622 | LSM3 | 27258 | 101256 | -0.3224 | 0.0000 | |
| GSE53624 | LSM3 | 27258 | 101256 | -0.1017 | 0.1826 | |
| GSE63941 | LSM3 | 27258 | 202209_at | 0.5248 | 0.2951 | |
| GSE77861 | LSM3 | 27258 | 202209_at | -0.6287 | 0.0120 | |
| GSE97050 | LSM3 | 27258 | A_24_P29001 | -0.3979 | 0.2782 | |
| SRP007169 | LSM3 | 27258 | RNAseq | -1.0545 | 0.0062 | |
| SRP008496 | LSM3 | 27258 | RNAseq | -0.9004 | 0.0000 | |
| SRP064894 | LSM3 | 27258 | RNAseq | -0.4384 | 0.0955 | |
| SRP133303 | LSM3 | 27258 | RNAseq | -0.2613 | 0.1590 | |
| SRP159526 | LSM3 | 27258 | RNAseq | -0.5829 | 0.0275 | |
| SRP193095 | LSM3 | 27258 | RNAseq | -0.8024 | 0.0000 | |
| SRP219564 | LSM3 | 27258 | RNAseq | -0.8652 | 0.0042 | |
| TCGA | LSM3 | 27258 | RNAseq | 0.0151 | 0.7974 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by LSM3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LSM3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LSM3 | 27258 | 1 | 19 | 10 | |
| GSE20123 | LSM3 | 27258 | 1 | 19 | 10 | |
| GSE43470 | LSM3 | 27258 | 0 | 21 | 22 | |
| GSE46452 | LSM3 | 27258 | 2 | 17 | 40 | |
| GSE47630 | LSM3 | 27258 | 2 | 23 | 15 | |
| GSE54993 | LSM3 | 27258 | 6 | 1 | 63 | |
| GSE54994 | LSM3 | 27258 | 1 | 32 | 20 | |
| GSE60625 | LSM3 | 27258 | 5 | 0 | 6 | |
| GSE74703 | LSM3 | 27258 | 0 | 17 | 19 | |
| GSE74704 | LSM3 | 27258 | 1 | 11 | 8 | |
| TCGA | LSM3 | 27258 | 2 | 68 | 26 |
Total number of gains: 21; Total number of losses: 228; Total Number of normals: 239.
Somatic mutations of LSM3:
Generating mutation plots.
Highly correlated genes for LSM3:
Showing top 20/682 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LSM3 | THRB | 0.818364 | 3 | 0 | 3 |
| LSM3 | ZCCHC9 | 0.722364 | 3 | 0 | 3 |
| LSM3 | NDUFA12 | 0.699829 | 5 | 0 | 5 |
| LSM3 | PINK1 | 0.696132 | 3 | 0 | 3 |
| LSM3 | FCHO2 | 0.683565 | 4 | 0 | 4 |
| LSM3 | ZBTB5 | 0.674415 | 4 | 0 | 4 |
| LSM3 | LSM11 | 0.673346 | 4 | 0 | 3 |
| LSM3 | ATXN7 | 0.668782 | 4 | 0 | 3 |
| LSM3 | EIF4EBP2 | 0.66779 | 4 | 0 | 3 |
| LSM3 | C15orf48 | 0.667361 | 3 | 0 | 3 |
| LSM3 | XK | 0.664951 | 4 | 0 | 3 |
| LSM3 | NFIA | 0.661088 | 5 | 0 | 5 |
| LSM3 | KLB | 0.657539 | 3 | 0 | 3 |
| LSM3 | PTGIS | 0.654525 | 3 | 0 | 3 |
| LSM3 | ZNF91 | 0.653944 | 4 | 0 | 4 |
| LSM3 | TAX1BP1 | 0.652759 | 3 | 0 | 3 |
| LSM3 | LRP10 | 0.652229 | 4 | 0 | 4 |
| LSM3 | PLBD1 | 0.651595 | 4 | 0 | 4 |
| LSM3 | UQCRC2 | 0.651217 | 7 | 0 | 6 |
| LSM3 | SLC16A6 | 0.650794 | 4 | 0 | 4 |
For details and further investigation, click here
