| Full name: aladin WD repeat nucleoporin | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12q13.13 | ||
| Entrez ID: 8086 | HGNC ID: HGNC:13666 | Ensembl Gene: ENSG00000094914 | OMIM ID: 605378 |
| Drug and gene relationship at DGIdb | |||
Expression of AAAS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AAAS | 8086 | 218075_at | -0.1552 | 0.6426 | |
| GSE20347 | AAAS | 8086 | 218075_at | 0.1974 | 0.0242 | |
| GSE23400 | AAAS | 8086 | 218075_at | 0.0519 | 0.0936 | |
| GSE26886 | AAAS | 8086 | 218075_at | 0.1328 | 0.1999 | |
| GSE29001 | AAAS | 8086 | 218075_at | -0.1501 | 0.4607 | |
| GSE38129 | AAAS | 8086 | 218075_at | 0.1893 | 0.0458 | |
| GSE45670 | AAAS | 8086 | 218075_at | 0.0279 | 0.7848 | |
| GSE53622 | AAAS | 8086 | 30752 | 0.3625 | 0.0000 | |
| GSE53624 | AAAS | 8086 | 30752 | 0.4437 | 0.0000 | |
| GSE63941 | AAAS | 8086 | 218075_at | 1.2451 | 0.0011 | |
| GSE77861 | AAAS | 8086 | 218075_at | 0.0672 | 0.6291 | |
| GSE97050 | AAAS | 8086 | A_23_P64799 | 0.0563 | 0.8358 | |
| SRP007169 | AAAS | 8086 | RNAseq | 0.4234 | 0.2923 | |
| SRP008496 | AAAS | 8086 | RNAseq | 0.4114 | 0.1114 | |
| SRP064894 | AAAS | 8086 | RNAseq | 0.3564 | 0.0316 | |
| SRP133303 | AAAS | 8086 | RNAseq | 0.2158 | 0.2017 | |
| SRP159526 | AAAS | 8086 | RNAseq | 0.2455 | 0.4115 | |
| SRP193095 | AAAS | 8086 | RNAseq | 0.1727 | 0.0425 | |
| SRP219564 | AAAS | 8086 | RNAseq | 0.0659 | 0.8183 | |
| TCGA | AAAS | 8086 | RNAseq | 0.1184 | 0.0298 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by AAAS expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AAAS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AAAS | 8086 | 7 | 1 | 22 | |
| GSE20123 | AAAS | 8086 | 7 | 1 | 22 | |
| GSE43470 | AAAS | 8086 | 3 | 0 | 40 | |
| GSE46452 | AAAS | 8086 | 7 | 1 | 51 | |
| GSE47630 | AAAS | 8086 | 10 | 2 | 28 | |
| GSE54993 | AAAS | 8086 | 0 | 5 | 65 | |
| GSE54994 | AAAS | 8086 | 4 | 1 | 48 | |
| GSE60625 | AAAS | 8086 | 0 | 0 | 11 | |
| GSE74703 | AAAS | 8086 | 3 | 0 | 33 | |
| GSE74704 | AAAS | 8086 | 5 | 1 | 14 | |
| TCGA | AAAS | 8086 | 14 | 11 | 71 |
Total number of gains: 60; Total number of losses: 23; Total Number of normals: 405.
Somatic mutations of AAAS:
Generating mutation plots.
Highly correlated genes for AAAS:
Showing top 20/661 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AAAS | CTDSP1 | 0.765094 | 5 | 0 | 4 |
| AAAS | SPTAN1 | 0.761496 | 5 | 0 | 5 |
| AAAS | NUCB1 | 0.761189 | 4 | 0 | 4 |
| AAAS | ORAI1 | 0.755173 | 3 | 0 | 3 |
| AAAS | NFIB | 0.753579 | 3 | 0 | 3 |
| AAAS | DAG1 | 0.747939 | 3 | 0 | 3 |
| AAAS | ALKBH7 | 0.73113 | 3 | 0 | 3 |
| AAAS | PTCD1 | 0.729995 | 3 | 0 | 3 |
| AAAS | PLCD3 | 0.729791 | 3 | 0 | 3 |
| AAAS | DNAJC19 | 0.728421 | 3 | 0 | 3 |
| AAAS | TTC26 | 0.723063 | 3 | 0 | 3 |
| AAAS | RAB4B | 0.72024 | 4 | 0 | 4 |
| AAAS | HYLS1 | 0.71517 | 3 | 0 | 3 |
| AAAS | C12orf65 | 0.71288 | 3 | 0 | 3 |
| AAAS | CAV3 | 0.7123 | 3 | 0 | 3 |
| AAAS | PROX1 | 0.708993 | 3 | 0 | 3 |
| AAAS | UNC45A | 0.706749 | 4 | 0 | 4 |
| AAAS | CPT1A | 0.706525 | 3 | 0 | 3 |
| AAAS | RPS24 | 0.702351 | 4 | 0 | 3 |
| AAAS | FAM89B | 0.698693 | 4 | 0 | 4 |
For details and further investigation, click here
