IFNAR1

 

Full name: interferon alpha and beta receptor subunit 1 Alias Symbol: IFRC
Type: protein-coding gene Cytoband: 21q22.11
Entrez ID: 3454 HGNC ID: HGNC:5432 Ensembl Gene: ENSG00000142166 OMIM ID: 107450
Drug and gene relationship at DGIdb

 

IFNAR1 involved pathways:

KEGG pathway Description View
hsa04151PI3K-Akt signaling pathway
hsa04380Osteoclast differentiation
hsa04620Toll-like receptor signaling pathway
hsa04630Jak-STAT signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa05160Hepatitis C
hsa05161Hepatitis B
hsa05162Measles
hsa05164Influenza A
hsa05168Herpes simplex infection

 

Expression of IFNAR1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 IFNAR1 3454 225669_at 0.2016 0.7481
GSE20347 IFNAR1 3454 204191_at -0.1955 0.0549
GSE23400 IFNAR1 3454 204191_at -0.1445 0.0004
GSE26886 IFNAR1 3454 225669_at -0.6188 0.0046
GSE29001 IFNAR1 3454 204191_at -0.0765 0.7306
GSE38129 IFNAR1 3454 204191_at -0.3012 0.0067
GSE45670 IFNAR1 3454 225669_at 0.1128 0.5350
GSE53622 IFNAR1 3454 98935 -0.4182 0.0000
GSE53624 IFNAR1 3454 65371 0.0610 0.5485
GSE63941 IFNAR1 3454 225661_at -0.9325 0.0590
GSE77861 IFNAR1 3454 225661_at -0.2726 0.1031
GSE97050 IFNAR1 3454 A_33_P3277988 -0.0341 0.8784
SRP007169 IFNAR1 3454 RNAseq -0.2065 0.6410
SRP008496 IFNAR1 3454 RNAseq -0.1320 0.6247
SRP064894 IFNAR1 3454 RNAseq 0.0787 0.6032
SRP133303 IFNAR1 3454 RNAseq -0.1047 0.3697
SRP159526 IFNAR1 3454 RNAseq -0.4174 0.1218
SRP193095 IFNAR1 3454 RNAseq -0.2924 0.0106
SRP219564 IFNAR1 3454 RNAseq -0.4315 0.0554
TCGA IFNAR1 3454 RNAseq -0.2106 0.0000

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by IFNAR1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of IFNAR1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 IFNAR1 3454 2 8 20
GSE20123 IFNAR1 3454 2 9 19
GSE43470 IFNAR1 3454 3 9 31
GSE46452 IFNAR1 3454 1 21 37
GSE47630 IFNAR1 3454 6 17 17
GSE54993 IFNAR1 3454 9 1 60
GSE54994 IFNAR1 3454 1 9 43
GSE60625 IFNAR1 3454 0 0 11
GSE74703 IFNAR1 3454 3 6 27
GSE74704 IFNAR1 3454 1 4 15
TCGA IFNAR1 3454 9 35 52

Total number of gains: 37; Total number of losses: 119; Total Number of normals: 332.  

 

Somatic mutations of IFNAR1:

 

Generating mutation plots.

 

Highly correlated genes for IFNAR1:

 

Showing top 20/537 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
IFNAR1ARHGAP420.835473303
IFNAR1TEX2610.827468303
IFNAR1TADA30.766372303
IFNAR1SLC24A10.752213303
IFNAR1MKRN10.749444303
IFNAR1GNB10.742809303
IFNAR1CDC260.741334303
IFNAR1STUB10.737475303
IFNAR1RNF2200.735864303
IFNAR1NCOR10.734178303
IFNAR1TMEM2180.729969303
IFNAR1MAP2K10.724206303
IFNAR1PYGO10.720808303
IFNAR1DEXI0.717309303
IFNAR1ECHDC10.713083303
IFNAR1GIMAP50.702006303
IFNAR1SCAI0.698504303
IFNAR1C2orf420.697889303
IFNAR1PPP2CB0.696725404
IFNAR1ZNF3980.695645303

For details and further investigation, click here