| Full name: transmembrane protein 106B | Alias Symbol: MGC33727|FLJ11273 | ||
| Type: protein-coding gene | Cytoband: 7p21.3 | ||
| Entrez ID: 54664 | HGNC ID: HGNC:22407 | Ensembl Gene: ENSG00000106460 | OMIM ID: 613413 |
| Drug and gene relationship at DGIdb | |||
Expression of TMEM106B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMEM106B | 54664 | 226529_at | -0.4244 | 0.3093 | |
| GSE20347 | TMEM106B | 54664 | 218930_s_at | 0.0830 | 0.7142 | |
| GSE23400 | TMEM106B | 54664 | 218930_s_at | 0.5272 | 0.0000 | |
| GSE26886 | TMEM106B | 54664 | 226529_at | 0.2248 | 0.4471 | |
| GSE29001 | TMEM106B | 54664 | 218930_s_at | 0.0261 | 0.9617 | |
| GSE38129 | TMEM106B | 54664 | 218930_s_at | 0.3875 | 0.0073 | |
| GSE45670 | TMEM106B | 54664 | 226529_at | -0.3159 | 0.0657 | |
| GSE53622 | TMEM106B | 54664 | 84188 | 0.0570 | 0.4510 | |
| GSE53624 | TMEM106B | 54664 | 84188 | 0.0986 | 0.1333 | |
| GSE63941 | TMEM106B | 54664 | 218930_s_at | -0.4227 | 0.4008 | |
| GSE77861 | TMEM106B | 54664 | 226529_at | -0.0862 | 0.7423 | |
| GSE97050 | TMEM106B | 54664 | A_23_P8522 | 0.0177 | 0.9575 | |
| SRP007169 | TMEM106B | 54664 | RNAseq | -0.2586 | 0.4995 | |
| SRP008496 | TMEM106B | 54664 | RNAseq | 0.1470 | 0.5892 | |
| SRP064894 | TMEM106B | 54664 | RNAseq | -0.0212 | 0.9170 | |
| SRP133303 | TMEM106B | 54664 | RNAseq | 0.4067 | 0.0018 | |
| SRP159526 | TMEM106B | 54664 | RNAseq | 0.0905 | 0.6058 | |
| SRP193095 | TMEM106B | 54664 | RNAseq | -0.1932 | 0.0207 | |
| SRP219564 | TMEM106B | 54664 | RNAseq | -0.0923 | 0.6504 | |
| TCGA | TMEM106B | 54664 | RNAseq | -0.0662 | 0.1859 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TMEM106B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMEM106B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMEM106B | 54664 | 14 | 2 | 14 | |
| GSE20123 | TMEM106B | 54664 | 14 | 2 | 14 | |
| GSE43470 | TMEM106B | 54664 | 5 | 0 | 38 | |
| GSE46452 | TMEM106B | 54664 | 11 | 1 | 47 | |
| GSE47630 | TMEM106B | 54664 | 9 | 1 | 30 | |
| GSE54993 | TMEM106B | 54664 | 0 | 6 | 64 | |
| GSE54994 | TMEM106B | 54664 | 22 | 1 | 30 | |
| GSE60625 | TMEM106B | 54664 | 0 | 0 | 11 | |
| GSE74703 | TMEM106B | 54664 | 5 | 0 | 31 | |
| GSE74704 | TMEM106B | 54664 | 8 | 2 | 10 | |
| TCGA | TMEM106B | 54664 | 54 | 7 | 35 |
Total number of gains: 142; Total number of losses: 22; Total Number of normals: 324.
Somatic mutations of TMEM106B:
Generating mutation plots.
Highly correlated genes for TMEM106B:
Showing top 20/411 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMEM106B | CBLL1 | 0.796132 | 3 | 0 | 3 |
| TMEM106B | INTS12 | 0.76881 | 3 | 0 | 3 |
| TMEM106B | IQGAP1 | 0.763292 | 3 | 0 | 3 |
| TMEM106B | SORL1 | 0.737347 | 3 | 0 | 3 |
| TMEM106B | JMJD1C | 0.734229 | 3 | 0 | 3 |
| TMEM106B | TMEM43 | 0.729566 | 3 | 0 | 3 |
| TMEM106B | ATP6V1E1 | 0.725931 | 3 | 0 | 3 |
| TMEM106B | MKLN1 | 0.722737 | 4 | 0 | 3 |
| TMEM106B | BCAS2 | 0.720475 | 4 | 0 | 3 |
| TMEM106B | IGSF10 | 0.712589 | 3 | 0 | 3 |
| TMEM106B | GPRC5B | 0.704658 | 4 | 0 | 4 |
| TMEM106B | MOB4 | 0.701672 | 4 | 0 | 4 |
| TMEM106B | LYRM1 | 0.696698 | 4 | 0 | 3 |
| TMEM106B | EPM2AIP1 | 0.69633 | 4 | 0 | 3 |
| TMEM106B | MAPK10 | 0.69497 | 3 | 0 | 3 |
| TMEM106B | SBF2 | 0.69473 | 5 | 0 | 4 |
| TMEM106B | RAPGEF6 | 0.691312 | 4 | 0 | 3 |
| TMEM106B | KIAA1143 | 0.688202 | 3 | 0 | 3 |
| TMEM106B | SEC24B | 0.686922 | 4 | 0 | 3 |
| TMEM106B | TTLL1 | 0.685722 | 3 | 0 | 3 |
For details and further investigation, click here
