| Full name: DNA polymerase delta 4, accessory subunit | Alias Symbol: p12|POLDS | ||
| Type: protein-coding gene | Cytoband: 11q13.2 | ||
| Entrez ID: 57804 | HGNC ID: HGNC:14106 | Ensembl Gene: ENSG00000175482 | OMIM ID: 611525 |
| Drug and gene relationship at DGIdb | |||
POLD4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05166 | HTLV-I infection |
Expression of POLD4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | POLD4 | 57804 | 202996_at | -0.3504 | 0.4157 | |
| GSE20347 | POLD4 | 57804 | 202996_at | -0.4125 | 0.0179 | |
| GSE23400 | POLD4 | 57804 | 202996_at | -0.2733 | 0.0000 | |
| GSE26886 | POLD4 | 57804 | 202996_at | 0.0801 | 0.6845 | |
| GSE29001 | POLD4 | 57804 | 202996_at | -0.7547 | 0.0051 | |
| GSE38129 | POLD4 | 57804 | 202996_at | -0.3754 | 0.0092 | |
| GSE45670 | POLD4 | 57804 | 202996_at | -0.1226 | 0.4971 | |
| GSE53622 | POLD4 | 57804 | 4449 | -0.4357 | 0.0000 | |
| GSE53624 | POLD4 | 57804 | 22603 | -0.5201 | 0.0000 | |
| GSE63941 | POLD4 | 57804 | 202996_at | 0.9985 | 0.1143 | |
| GSE77861 | POLD4 | 57804 | 202996_at | -0.1161 | 0.6473 | |
| GSE97050 | POLD4 | 57804 | A_23_P127367 | 0.1236 | 0.7367 | |
| SRP007169 | POLD4 | 57804 | RNAseq | -1.8866 | 0.0000 | |
| SRP008496 | POLD4 | 57804 | RNAseq | -1.7744 | 0.0000 | |
| SRP064894 | POLD4 | 57804 | RNAseq | -0.1696 | 0.6123 | |
| SRP133303 | POLD4 | 57804 | RNAseq | -0.1662 | 0.3741 | |
| SRP159526 | POLD4 | 57804 | RNAseq | -0.7809 | 0.0005 | |
| SRP193095 | POLD4 | 57804 | RNAseq | -0.8256 | 0.0000 | |
| SRP219564 | POLD4 | 57804 | RNAseq | -0.4102 | 0.2919 | |
| TCGA | POLD4 | 57804 | RNAseq | -0.0722 | 0.3313 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by POLD4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of POLD4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | POLD4 | 57804 | 8 | 4 | 18 | |
| GSE20123 | POLD4 | 57804 | 8 | 4 | 18 | |
| GSE43470 | POLD4 | 57804 | 6 | 1 | 36 | |
| GSE46452 | POLD4 | 57804 | 13 | 3 | 43 | |
| GSE47630 | POLD4 | 57804 | 8 | 5 | 27 | |
| GSE54993 | POLD4 | 57804 | 3 | 1 | 66 | |
| GSE54994 | POLD4 | 57804 | 13 | 4 | 36 | |
| GSE60625 | POLD4 | 57804 | 0 | 3 | 8 | |
| GSE74703 | POLD4 | 57804 | 4 | 0 | 32 | |
| GSE74704 | POLD4 | 57804 | 7 | 2 | 11 | |
| TCGA | POLD4 | 57804 | 28 | 8 | 60 |
Total number of gains: 98; Total number of losses: 35; Total Number of normals: 355.
Somatic mutations of POLD4:
Generating mutation plots.
Highly correlated genes for POLD4:
Showing top 20/696 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| POLD4 | SNX14 | 0.767429 | 3 | 0 | 3 |
| POLD4 | KCNK6 | 0.767025 | 3 | 0 | 3 |
| POLD4 | GPR108 | 0.759705 | 3 | 0 | 3 |
| POLD4 | TAF12 | 0.731788 | 3 | 0 | 3 |
| POLD4 | MAPK11 | 0.729556 | 3 | 0 | 3 |
| POLD4 | TNFSF9 | 0.705808 | 3 | 0 | 3 |
| POLD4 | RNF40 | 0.699863 | 3 | 0 | 3 |
| POLD4 | SESN2 | 0.699332 | 4 | 0 | 4 |
| POLD4 | COMTD1 | 0.68717 | 5 | 0 | 4 |
| POLD4 | ITGB5 | 0.686487 | 3 | 0 | 3 |
| POLD4 | TMEM19 | 0.680309 | 4 | 0 | 4 |
| POLD4 | FAM122A | 0.666038 | 4 | 0 | 3 |
| POLD4 | TOM1 | 0.662538 | 10 | 0 | 9 |
| POLD4 | TAX1BP3 | 0.660331 | 4 | 0 | 3 |
| POLD4 | ELOVL1 | 0.658199 | 4 | 0 | 3 |
| POLD4 | MAP2K3 | 0.656099 | 3 | 0 | 3 |
| POLD4 | XBP1 | 0.654199 | 3 | 0 | 3 |
| POLD4 | ATP6AP1 | 0.652854 | 8 | 0 | 8 |
| POLD4 | TSHZ2 | 0.6519 | 4 | 0 | 3 |
| POLD4 | A2ML1 | 0.647816 | 3 | 0 | 3 |
For details and further investigation, click here
