| Full name: mitogen-activated protein kinase 7 | Alias Symbol: BMK1|ERK5 | ||
| Type: protein-coding gene | Cytoband: 17p11.2 | ||
| Entrez ID: 5598 | HGNC ID: HGNC:6880 | Ensembl Gene: ENSG00000166484 | OMIM ID: 602521 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
MAPK7 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04540 | Gap junction | |
| hsa04722 | Neurotrophin signaling pathway | |
| hsa04912 | GnRH signaling pathway | |
| hsa04921 | Oxytocin signaling pathway |
Expression of MAPK7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MAPK7 | 5598 | 207292_s_at | -0.3198 | 0.2608 | |
| GSE20347 | MAPK7 | 5598 | 207292_s_at | -0.4257 | 0.0000 | |
| GSE23400 | MAPK7 | 5598 | 207292_s_at | -0.2661 | 0.0000 | |
| GSE26886 | MAPK7 | 5598 | 207292_s_at | 0.1683 | 0.1906 | |
| GSE29001 | MAPK7 | 5598 | 207292_s_at | -0.4694 | 0.0065 | |
| GSE38129 | MAPK7 | 5598 | 207292_s_at | -0.3322 | 0.0002 | |
| GSE45670 | MAPK7 | 5598 | 207292_s_at | -0.3399 | 0.0045 | |
| GSE53622 | MAPK7 | 5598 | 9146 | -0.5440 | 0.0000 | |
| GSE53624 | MAPK7 | 5598 | 9146 | -0.5676 | 0.0000 | |
| GSE63941 | MAPK7 | 5598 | 35617_at | -1.1505 | 0.0097 | |
| GSE77861 | MAPK7 | 5598 | 207292_s_at | -0.2730 | 0.0840 | |
| GSE97050 | MAPK7 | 5598 | A_23_P100704 | -0.1070 | 0.7421 | |
| SRP007169 | MAPK7 | 5598 | RNAseq | -1.3021 | 0.0102 | |
| SRP008496 | MAPK7 | 5598 | RNAseq | -1.0186 | 0.0039 | |
| SRP064894 | MAPK7 | 5598 | RNAseq | -0.2114 | 0.3350 | |
| SRP133303 | MAPK7 | 5598 | RNAseq | -0.5786 | 0.0009 | |
| SRP159526 | MAPK7 | 5598 | RNAseq | -0.8670 | 0.0021 | |
| SRP193095 | MAPK7 | 5598 | RNAseq | -0.5247 | 0.0001 | |
| SRP219564 | MAPK7 | 5598 | RNAseq | -0.4933 | 0.2236 | |
| TCGA | MAPK7 | 5598 | RNAseq | -0.0056 | 0.9222 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by MAPK7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MAPK7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MAPK7 | 5598 | 4 | 3 | 23 | |
| GSE20123 | MAPK7 | 5598 | 4 | 4 | 22 | |
| GSE43470 | MAPK7 | 5598 | 1 | 5 | 37 | |
| GSE46452 | MAPK7 | 5598 | 34 | 1 | 24 | |
| GSE47630 | MAPK7 | 5598 | 7 | 1 | 32 | |
| GSE54993 | MAPK7 | 5598 | 3 | 3 | 64 | |
| GSE54994 | MAPK7 | 5598 | 6 | 6 | 41 | |
| GSE60625 | MAPK7 | 5598 | 4 | 0 | 7 | |
| GSE74703 | MAPK7 | 5598 | 1 | 2 | 33 | |
| GSE74704 | MAPK7 | 5598 | 3 | 1 | 16 | |
| TCGA | MAPK7 | 5598 | 19 | 24 | 53 |
Total number of gains: 86; Total number of losses: 50; Total Number of normals: 352.
Somatic mutations of MAPK7:
Generating mutation plots.
Highly correlated genes for MAPK7:
Showing top 20/564 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MAPK7 | GAB3 | 0.753664 | 3 | 0 | 3 |
| MAPK7 | TMEM129 | 0.735213 | 3 | 0 | 3 |
| MAPK7 | ZNF578 | 0.716792 | 3 | 0 | 3 |
| MAPK7 | STOML1 | 0.714919 | 3 | 0 | 3 |
| MAPK7 | RNF208 | 0.69906 | 9 | 0 | 9 |
| MAPK7 | TRIM8 | 0.693705 | 3 | 0 | 3 |
| MAPK7 | TAX1BP3 | 0.68864 | 3 | 0 | 3 |
| MAPK7 | DDI2 | 0.685411 | 3 | 0 | 3 |
| MAPK7 | COMTD1 | 0.683654 | 5 | 0 | 5 |
| MAPK7 | ZNF143 | 0.683564 | 3 | 0 | 3 |
| MAPK7 | ADAMTS10 | 0.682091 | 3 | 0 | 3 |
| MAPK7 | ZFAND2B | 0.67684 | 7 | 0 | 7 |
| MAPK7 | EPGN | 0.675047 | 3 | 0 | 3 |
| MAPK7 | RABEP2 | 0.670908 | 6 | 0 | 6 |
| MAPK7 | UBAP1 | 0.668291 | 9 | 0 | 8 |
| MAPK7 | ZC3H3 | 0.668089 | 3 | 0 | 3 |
| MAPK7 | SH3GL1 | 0.660955 | 10 | 0 | 10 |
| MAPK7 | SNX33 | 0.658931 | 5 | 0 | 4 |
| MAPK7 | STAM | 0.655734 | 3 | 0 | 3 |
| MAPK7 | LY9 | 0.655439 | 4 | 0 | 4 |
For details and further investigation, click here
