| Full name: muscleblind like splicing regulator 1 | Alias Symbol: KIAA0428|EXP42|EXP40|EXP35|EXP | ||
| Type: protein-coding gene | Cytoband: 3q25.1-q25.2 | ||
| Entrez ID: 4154 | HGNC ID: HGNC:6923 | Ensembl Gene: ENSG00000152601 | OMIM ID: 606516 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of MBNL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MBNL1 | 4154 | 201153_s_at | -0.1062 | 0.7618 | |
| GSE20347 | MBNL1 | 4154 | 201152_s_at | 0.0944 | 0.3895 | |
| GSE23400 | MBNL1 | 4154 | 201152_s_at | 0.2792 | 0.0089 | |
| GSE26886 | MBNL1 | 4154 | 201153_s_at | 0.5747 | 0.0073 | |
| GSE29001 | MBNL1 | 4154 | 201152_s_at | 0.4129 | 0.3739 | |
| GSE38129 | MBNL1 | 4154 | 201152_s_at | -0.2445 | 0.0816 | |
| GSE45670 | MBNL1 | 4154 | 201152_s_at | -0.2917 | 0.0131 | |
| GSE53622 | MBNL1 | 4154 | 33873 | -0.1537 | 0.0132 | |
| GSE53624 | MBNL1 | 4154 | 33873 | 0.1579 | 0.0001 | |
| GSE63941 | MBNL1 | 4154 | 201153_s_at | -0.6576 | 0.1397 | |
| GSE77861 | MBNL1 | 4154 | 201152_s_at | 0.4798 | 0.1006 | |
| GSE97050 | MBNL1 | 4154 | A_23_P357811 | -0.2156 | 0.3904 | |
| SRP007169 | MBNL1 | 4154 | RNAseq | 0.8675 | 0.0222 | |
| SRP008496 | MBNL1 | 4154 | RNAseq | 0.9693 | 0.0000 | |
| SRP064894 | MBNL1 | 4154 | RNAseq | 0.1885 | 0.3035 | |
| SRP133303 | MBNL1 | 4154 | RNAseq | 0.1994 | 0.1720 | |
| SRP159526 | MBNL1 | 4154 | RNAseq | -0.1683 | 0.6055 | |
| SRP193095 | MBNL1 | 4154 | RNAseq | 0.1951 | 0.0553 | |
| SRP219564 | MBNL1 | 4154 | RNAseq | -0.1988 | 0.6363 | |
| TCGA | MBNL1 | 4154 | RNAseq | 0.0758 | 0.0841 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MBNL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MBNL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MBNL1 | 4154 | 21 | 0 | 9 | |
| GSE20123 | MBNL1 | 4154 | 21 | 0 | 9 | |
| GSE43470 | MBNL1 | 4154 | 23 | 0 | 20 | |
| GSE46452 | MBNL1 | 4154 | 18 | 2 | 39 | |
| GSE47630 | MBNL1 | 4154 | 19 | 3 | 18 | |
| GSE54993 | MBNL1 | 4154 | 1 | 10 | 59 | |
| GSE54994 | MBNL1 | 4154 | 37 | 1 | 15 | |
| GSE60625 | MBNL1 | 4154 | 0 | 6 | 5 | |
| GSE74703 | MBNL1 | 4154 | 20 | 0 | 16 | |
| GSE74704 | MBNL1 | 4154 | 13 | 0 | 7 | |
| TCGA | MBNL1 | 4154 | 72 | 1 | 23 |
Total number of gains: 245; Total number of losses: 23; Total Number of normals: 220.
Somatic mutations of MBNL1:
Generating mutation plots.
Highly correlated genes for MBNL1:
Showing top 20/751 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MBNL1 | KLF10 | 0.786356 | 3 | 0 | 3 |
| MBNL1 | FGF12 | 0.765322 | 3 | 0 | 3 |
| MBNL1 | OSBPL9 | 0.750315 | 3 | 0 | 3 |
| MBNL1 | CFL2 | 0.730834 | 4 | 0 | 4 |
| MBNL1 | TFDP2 | 0.720729 | 3 | 0 | 3 |
| MBNL1 | CBLL1 | 0.717033 | 3 | 0 | 3 |
| MBNL1 | PTCD3 | 0.716057 | 3 | 0 | 3 |
| MBNL1 | TRMT61B | 0.712205 | 3 | 0 | 3 |
| MBNL1 | ALKBH6 | 0.708033 | 3 | 0 | 3 |
| MBNL1 | PAK2 | 0.69387 | 6 | 0 | 5 |
| MBNL1 | ANG | 0.689505 | 3 | 0 | 3 |
| MBNL1 | NSUN5 | 0.688995 | 3 | 0 | 3 |
| MBNL1 | LSM11 | 0.686113 | 4 | 0 | 3 |
| MBNL1 | RBMX2 | 0.685785 | 4 | 0 | 3 |
| MBNL1 | DDIT3 | 0.683986 | 4 | 0 | 3 |
| MBNL1 | PTPN4 | 0.683814 | 4 | 0 | 4 |
| MBNL1 | DET1 | 0.681635 | 3 | 0 | 3 |
| MBNL1 | EPB41L2 | 0.679458 | 5 | 0 | 5 |
| MBNL1 | FNDC5 | 0.67491 | 3 | 0 | 3 |
| MBNL1 | CDC42EP4 | 0.672448 | 4 | 0 | 4 |
For details and further investigation, click here
