PAK2

 

Full name: p21 (RAC1) activated kinase 2 Alias Symbol: PAK65|PAKgamma
Type: protein-coding gene Cytoband: 3q29
Entrez ID: 5062 HGNC ID: HGNC:8591 Ensembl Gene: ENSG00000180370 OMIM ID: 605022
Drug and gene relationship at DGIdb
Screen Evidence:

 

PAK2 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04012ErbB signaling pathway
hsa04014Ras signaling pathway
hsa04360Axon guidance
hsa04510Focal adhesion
hsa04660T cell receptor signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa05211Renal cell carcinoma

 

Expression of PAK2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PAK2 5062 208877_at 0.5260 0.3107
GSE20347 PAK2 5062 208877_at 0.5278 0.0004
GSE23400 PAK2 5062 208875_s_at 0.9826 0.0000
GSE26886 PAK2 5062 208877_at 0.3676 0.0549
GSE29001 PAK2 5062 208877_at 0.6340 0.0155
GSE38129 PAK2 5062 208877_at 0.5877 0.0001
GSE45670 PAK2 5062 208877_at 0.4614 0.0038
GSE53622 PAK2 5062 9962 0.6226 0.0000
GSE53624 PAK2 5062 9962 0.7200 0.0000
GSE63941 PAK2 5062 208877_at -0.8802 0.1190
GSE77861 PAK2 5062 208877_at 1.0246 0.0135
GSE97050 PAK2 5062 A_33_P3220833 0.3926 0.1897
SRP007169 PAK2 5062 RNAseq 0.8735 0.0060
SRP008496 PAK2 5062 RNAseq 1.2464 0.0000
SRP064894 PAK2 5062 RNAseq 0.5471 0.0010
SRP133303 PAK2 5062 RNAseq 1.0003 0.0000
SRP159526 PAK2 5062 RNAseq 0.9204 0.0028
SRP193095 PAK2 5062 RNAseq 0.6959 0.0000
SRP219564 PAK2 5062 RNAseq 0.4501 0.0789
TCGA PAK2 5062 RNAseq 0.2003 0.0000

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by PAK2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PAK2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PAK2 5062 22 0 8
GSE20123 PAK2 5062 22 0 8
GSE43470 PAK2 5062 21 0 22
GSE46452 PAK2 5062 19 1 39
GSE47630 PAK2 5062 27 2 11
GSE54993 PAK2 5062 1 22 47
GSE54994 PAK2 5062 41 0 12
GSE60625 PAK2 5062 0 6 5
GSE74703 PAK2 5062 19 0 17
GSE74704 PAK2 5062 14 0 6
TCGA PAK2 5062 76 1 19

Total number of gains: 262; Total number of losses: 32; Total Number of normals: 194.  

 

Somatic mutations of PAK2:

 

Generating mutation plots.

 

Highly correlated genes for PAK2:

 

Showing top 20/1581 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PAK2TRIM350.782156303
PAK2ALG80.756038303
PAK2ALKBH60.751464403
PAK2RPL39L0.740273909
PAK2ITGB80.739709404
PAK2SRSF60.739351303
PAK2ETS20.734192303
PAK2VPS37A0.725851303
PAK2NCS10.721477303
PAK2SMC50.712904303
PAK2PRKAA10.709334303
PAK2MRPL470.708372707
PAK2MRPS50.70832303
PAK2SSBP40.707981303
PAK2LURAP1L0.703915404
PAK2FXR10.70279710010
PAK2CDC42EP30.702309404
PAK2RFC40.6985521009
PAK2ACTL6A0.69558912010
PAK2MASTL0.694803504

For details and further investigation, click here