| Full name: malonyl-CoA-acyl carrier protein transacylase | Alias Symbol: MT|MCT|fabD|FASN2C|NET62|MCT1 | ||
| Type: protein-coding gene | Cytoband: 22q13.2 | ||
| Entrez ID: 27349 | HGNC ID: HGNC:29622 | Ensembl Gene: ENSG00000100294 | OMIM ID: 614479 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MCAT:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MCAT | 27349 | 213132_s_at | 0.4841 | 0.2981 | |
| GSE20347 | MCAT | 27349 | 213132_s_at | 0.0319 | 0.8630 | |
| GSE23400 | MCAT | 27349 | 213132_s_at | -0.0413 | 0.4137 | |
| GSE26886 | MCAT | 27349 | 213132_s_at | -0.1177 | 0.6429 | |
| GSE29001 | MCAT | 27349 | 213132_s_at | -0.0779 | 0.7934 | |
| GSE38129 | MCAT | 27349 | 213132_s_at | 0.1815 | 0.1424 | |
| GSE45670 | MCAT | 27349 | 213132_s_at | 0.1377 | 0.3897 | |
| GSE53622 | MCAT | 27349 | 36230 | -0.1353 | 0.0026 | |
| GSE53624 | MCAT | 27349 | 36230 | -0.1715 | 0.0009 | |
| GSE63941 | MCAT | 27349 | 213132_s_at | 0.3527 | 0.4319 | |
| GSE77861 | MCAT | 27349 | 213132_s_at | 0.0986 | 0.6267 | |
| GSE97050 | MCAT | 27349 | A_23_P132358 | -0.0566 | 0.7989 | |
| SRP007169 | MCAT | 27349 | RNAseq | -0.4880 | 0.1897 | |
| SRP008496 | MCAT | 27349 | RNAseq | -0.6000 | 0.0126 | |
| SRP064894 | MCAT | 27349 | RNAseq | 0.3694 | 0.2238 | |
| SRP133303 | MCAT | 27349 | RNAseq | -0.0701 | 0.6403 | |
| SRP159526 | MCAT | 27349 | RNAseq | 0.2875 | 0.2103 | |
| SRP193095 | MCAT | 27349 | RNAseq | 0.0369 | 0.7217 | |
| SRP219564 | MCAT | 27349 | RNAseq | -0.1184 | 0.5632 | |
| TCGA | MCAT | 27349 | RNAseq | -0.0098 | 0.8739 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MCAT expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MCAT:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MCAT | 27349 | 6 | 6 | 18 | |
| GSE20123 | MCAT | 27349 | 6 | 5 | 19 | |
| GSE43470 | MCAT | 27349 | 3 | 6 | 34 | |
| GSE46452 | MCAT | 27349 | 31 | 2 | 26 | |
| GSE47630 | MCAT | 27349 | 9 | 4 | 27 | |
| GSE54993 | MCAT | 27349 | 3 | 6 | 61 | |
| GSE54994 | MCAT | 27349 | 11 | 8 | 34 | |
| GSE60625 | MCAT | 27349 | 5 | 0 | 6 | |
| GSE74703 | MCAT | 27349 | 3 | 4 | 29 | |
| GSE74704 | MCAT | 27349 | 3 | 3 | 14 | |
| TCGA | MCAT | 27349 | 26 | 15 | 55 |
Total number of gains: 106; Total number of losses: 59; Total Number of normals: 323.
Somatic mutations of MCAT:
Generating mutation plots.
Highly correlated genes for MCAT:
Showing top 20/273 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MCAT | PIGU | 0.843505 | 3 | 0 | 3 |
| MCAT | BTF3L4 | 0.763349 | 3 | 0 | 3 |
| MCAT | ENO1 | 0.704914 | 4 | 0 | 3 |
| MCAT | ZNF668 | 0.691758 | 4 | 0 | 4 |
| MCAT | VPS28 | 0.661119 | 3 | 0 | 3 |
| MCAT | TOMM22 | 0.657312 | 8 | 0 | 6 |
| MCAT | PSENEN | 0.654578 | 4 | 0 | 4 |
| MCAT | XRCC6 | 0.653551 | 9 | 0 | 7 |
| MCAT | ERGIC3 | 0.649971 | 5 | 0 | 4 |
| MCAT | POLR3H | 0.647786 | 5 | 0 | 5 |
| MCAT | RPL8 | 0.646445 | 6 | 0 | 5 |
| MCAT | EXOC6 | 0.645862 | 3 | 0 | 3 |
| MCAT | AK2 | 0.643322 | 4 | 0 | 3 |
| MCAT | MOB1A | 0.640855 | 3 | 0 | 3 |
| MCAT | AHCY | 0.638361 | 5 | 0 | 4 |
| MCAT | ERP29 | 0.632088 | 4 | 0 | 3 |
| MCAT | RPLP0 | 0.630217 | 5 | 0 | 4 |
| MCAT | CDC123 | 0.625863 | 5 | 0 | 4 |
| MCAT | PGK1 | 0.625809 | 4 | 0 | 4 |
| MCAT | HNRNPAB | 0.625447 | 5 | 0 | 4 |
For details and further investigation, click here
