| Full name: malate dehydrogenase 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 7q11.23 | ||
| Entrez ID: 4191 | HGNC ID: HGNC:6971 | Ensembl Gene: ENSG00000146701 | OMIM ID: 154100 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of MDH2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MDH2 | 4191 | 209036_s_at | 0.1065 | 0.8267 | |
| GSE20347 | MDH2 | 4191 | 209036_s_at | -0.0420 | 0.8502 | |
| GSE23400 | MDH2 | 4191 | 209036_s_at | -0.0546 | 0.4848 | |
| GSE26886 | MDH2 | 4191 | 209036_s_at | 0.0551 | 0.6931 | |
| GSE29001 | MDH2 | 4191 | 209036_s_at | -0.2744 | 0.4771 | |
| GSE38129 | MDH2 | 4191 | 209036_s_at | 0.1727 | 0.2339 | |
| GSE45670 | MDH2 | 4191 | 209036_s_at | 0.1430 | 0.2948 | |
| GSE53622 | MDH2 | 4191 | 56244 | -0.1747 | 0.0034 | |
| GSE53624 | MDH2 | 4191 | 56244 | 0.1621 | 0.0093 | |
| GSE63941 | MDH2 | 4191 | 209036_s_at | 0.7317 | 0.0165 | |
| GSE77861 | MDH2 | 4191 | 209036_s_at | -0.0957 | 0.6572 | |
| GSE97050 | MDH2 | 4191 | A_23_P31372 | 0.0110 | 0.9770 | |
| SRP007169 | MDH2 | 4191 | RNAseq | -0.6877 | 0.0326 | |
| SRP008496 | MDH2 | 4191 | RNAseq | -0.6760 | 0.0045 | |
| SRP064894 | MDH2 | 4191 | RNAseq | -0.0444 | 0.8547 | |
| SRP133303 | MDH2 | 4191 | RNAseq | 0.0676 | 0.6932 | |
| SRP159526 | MDH2 | 4191 | RNAseq | -0.0900 | 0.7354 | |
| SRP193095 | MDH2 | 4191 | RNAseq | -0.1189 | 0.3891 | |
| SRP219564 | MDH2 | 4191 | RNAseq | 0.0353 | 0.9069 | |
| TCGA | MDH2 | 4191 | RNAseq | 0.0438 | 0.3572 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MDH2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MDH2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MDH2 | 4191 | 14 | 1 | 15 | |
| GSE20123 | MDH2 | 4191 | 14 | 1 | 15 | |
| GSE43470 | MDH2 | 4191 | 3 | 2 | 38 | |
| GSE46452 | MDH2 | 4191 | 12 | 0 | 47 | |
| GSE47630 | MDH2 | 4191 | 7 | 2 | 31 | |
| GSE54993 | MDH2 | 4191 | 2 | 7 | 61 | |
| GSE54994 | MDH2 | 4191 | 14 | 3 | 36 | |
| GSE60625 | MDH2 | 4191 | 0 | 0 | 11 | |
| GSE74703 | MDH2 | 4191 | 3 | 1 | 32 | |
| GSE74704 | MDH2 | 4191 | 8 | 1 | 11 | |
| TCGA | MDH2 | 4191 | 44 | 5 | 47 |
Total number of gains: 121; Total number of losses: 23; Total Number of normals: 344.
Somatic mutations of MDH2:
Generating mutation plots.
Highly correlated genes for MDH2:
Showing top 20/573 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MDH2 | HIC2 | 0.81574 | 3 | 0 | 3 |
| MDH2 | FBXW8 | 0.781178 | 3 | 0 | 3 |
| MDH2 | PPIL1 | 0.77024 | 3 | 0 | 3 |
| MDH2 | KDM2B | 0.752528 | 3 | 0 | 3 |
| MDH2 | ECD | 0.720186 | 3 | 0 | 3 |
| MDH2 | TERF2 | 0.719217 | 3 | 0 | 3 |
| MDH2 | ANAPC5 | 0.717472 | 4 | 0 | 4 |
| MDH2 | TMEM120A | 0.713105 | 3 | 0 | 3 |
| MDH2 | ANKRD16 | 0.712732 | 3 | 0 | 3 |
| MDH2 | OSBPL8 | 0.712448 | 3 | 0 | 3 |
| MDH2 | TMSB4Y | 0.709832 | 3 | 0 | 3 |
| MDH2 | CNOT10 | 0.708916 | 4 | 0 | 3 |
| MDH2 | SOS1 | 0.703751 | 3 | 0 | 3 |
| MDH2 | RAB1A | 0.70065 | 4 | 0 | 4 |
| MDH2 | SLC35C2 | 0.700644 | 3 | 0 | 3 |
| MDH2 | ZNF41 | 0.699509 | 3 | 0 | 3 |
| MDH2 | SRSF6 | 0.683772 | 3 | 0 | 3 |
| MDH2 | MMS19 | 0.680982 | 4 | 0 | 4 |
| MDH2 | TMEM219 | 0.679631 | 3 | 0 | 3 |
| MDH2 | CAT | 0.678851 | 3 | 0 | 3 |
For details and further investigation, click here
