MED27

 

Full name: mediator complex subunit 27 Alias Symbol: TRAP37|CRSP34|MED3
Type: protein-coding gene Cytoband: 9q34.13
Entrez ID: 9442 HGNC ID: HGNC:2377 Ensembl Gene: ENSG00000160563 OMIM ID: 605044
Drug and gene relationship at DGIdb

 

Expression of MED27:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MED27 9442 51176_at 0.1977 0.5940
GSE20347 MED27 9442 51176_at 0.2632 0.0743
GSE23400 MED27 9442 51176_at 0.0979 0.0029
GSE26886 MED27 9442 51176_at 0.7600 0.0002
GSE29001 MED27 9442 51176_at 0.2664 0.0541
GSE38129 MED27 9442 51176_at 0.4110 0.0018
GSE45670 MED27 9442 51176_at 0.3239 0.0507
GSE53622 MED27 9442 67388 0.5982 0.0000
GSE53624 MED27 9442 67388 0.5659 0.0000
GSE63941 MED27 9442 51176_at 0.7888 0.0215
GSE77861 MED27 9442 51176_at 0.2936 0.1379
GSE97050 MED27 9442 A_23_P301877 0.5544 0.1189
SRP007169 MED27 9442 RNAseq 0.8893 0.0322
SRP008496 MED27 9442 RNAseq 1.0088 0.0001
SRP064894 MED27 9442 RNAseq 0.7909 0.0009
SRP133303 MED27 9442 RNAseq 0.5679 0.0010
SRP159526 MED27 9442 RNAseq 0.8978 0.0006
SRP193095 MED27 9442 RNAseq 0.4618 0.0010
SRP219564 MED27 9442 RNAseq 0.2970 0.3685
TCGA MED27 9442 RNAseq 0.2992 0.0000

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by MED27 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MED27:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MED27 9442 7 8 15
GSE20123 MED27 9442 7 8 15
GSE43470 MED27 9442 5 7 31
GSE46452 MED27 9442 6 13 40
GSE47630 MED27 9442 4 15 21
GSE54993 MED27 9442 3 3 64
GSE54994 MED27 9442 12 9 32
GSE60625 MED27 9442 0 0 11
GSE74703 MED27 9442 5 5 26
GSE74704 MED27 9442 4 6 10
TCGA MED27 9442 28 26 42

Total number of gains: 81; Total number of losses: 100; Total Number of normals: 307.  

 

Somatic mutations of MED27:

 

Generating mutation plots.

 

Highly correlated genes for MED27:

 

Showing top 20/1142 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MED27WIPI10.829624303
MED27PRELID10.805624303
MED27ZNF3190.786786303
MED27CATSPER10.775125303
MED27C3orf330.750183303
MED27PIGS0.745313303
MED27SEMA3C0.738768303
MED27SLC39A30.734053303
MED27ACVRL10.729396303
MED27PLEKHM30.725039303
MED27ATXN3L0.715059303
MED27ELFN10.712035303
MED27TMEM38B0.708027606
MED27POLR2A0.703809403
MED27QSOX20.697628504
MED27NTMT10.693743606
MED27GNG100.692463404
MED27FBXW90.691893303
MED27ACAP20.691645303
MED27VBP10.691126606

For details and further investigation, click here