| Full name: maternally expressed 3 | Alias Symbol: GTL2|NCRNA00023|LINC00023|onco-lncRNA-83 | ||
| Type: non-coding RNA | Cytoband: 14q32.2 | ||
| Entrez ID: 55384 | HGNC ID: HGNC:14575 | Ensembl Gene: ENSG00000214548 | OMIM ID: 605636 |
| Drug and gene relationship at DGIdb | |||
Expression of MEG3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MEG3 | 55384 | 210794_s_at | -0.5008 | 0.2446 | |
| GSE20347 | MEG3 | 55384 | 210794_s_at | -0.0529 | 0.6778 | |
| GSE23400 | MEG3 | 55384 | 210794_s_at | -0.0760 | 0.5681 | |
| GSE26886 | MEG3 | 55384 | 210794_s_at | 0.8341 | 0.0021 | |
| GSE29001 | MEG3 | 55384 | 210794_s_at | 0.0209 | 0.9597 | |
| GSE38129 | MEG3 | 55384 | 210794_s_at | -0.2032 | 0.1444 | |
| GSE45670 | MEG3 | 55384 | 210794_s_at | -0.6502 | 0.0019 | |
| GSE53622 | MEG3 | 55384 | 114388 | -0.5696 | 0.0010 | |
| GSE53624 | MEG3 | 55384 | 114388 | -0.8787 | 0.0000 | |
| GSE63941 | MEG3 | 55384 | 210794_s_at | -2.5220 | 0.0002 | |
| GSE77861 | MEG3 | 55384 | 1558144_at | -0.1948 | 0.1280 | |
| SRP007169 | MEG3 | 55384 | RNAseq | 3.8221 | 0.0000 | |
| SRP064894 | MEG3 | 55384 | RNAseq | 0.6502 | 0.1328 | |
| SRP133303 | MEG3 | 55384 | RNAseq | -0.1915 | 0.5891 | |
| SRP159526 | MEG3 | 55384 | RNAseq | -0.6416 | 0.0644 | |
| SRP193095 | MEG3 | 55384 | RNAseq | 1.8484 | 0.0000 | |
| SRP219564 | MEG3 | 55384 | RNAseq | 0.5265 | 0.3776 | |
| TCGA | MEG3 | 55384 | RNAseq | -0.6829 | 0.0012 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by MEG3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MEG3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MEG3 | 55384 | 9 | 5 | 16 | |
| GSE20123 | MEG3 | 55384 | 9 | 4 | 17 | |
| GSE43470 | MEG3 | 55384 | 7 | 4 | 32 | |
| GSE46452 | MEG3 | 55384 | 18 | 3 | 38 | |
| GSE47630 | MEG3 | 55384 | 11 | 8 | 21 | |
| GSE54993 | MEG3 | 55384 | 3 | 8 | 59 | |
| GSE54994 | MEG3 | 55384 | 21 | 4 | 28 | |
| GSE60625 | MEG3 | 55384 | 0 | 2 | 9 | |
| GSE74703 | MEG3 | 55384 | 6 | 3 | 27 | |
| GSE74704 | MEG3 | 55384 | 5 | 3 | 12 | |
| TCGA | MEG3 | 55384 | 32 | 17 | 47 |
Total number of gains: 121; Total number of losses: 61; Total Number of normals: 306.
Somatic mutations of MEG3:
Generating mutation plots.
Highly correlated genes for MEG3:
Showing top 20/204 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MEG3 | SNORD114-3 | 0.727225 | 6 | 0 | 5 |
| MEG3 | TCF21 | 0.712414 | 4 | 0 | 4 |
| MEG3 | NPR2 | 0.709541 | 4 | 0 | 4 |
| MEG3 | PID1 | 0.707426 | 3 | 0 | 3 |
| MEG3 | EVC2 | 0.699971 | 3 | 0 | 3 |
| MEG3 | HMCN1 | 0.698543 | 3 | 0 | 3 |
| MEG3 | ZFPM2 | 0.698278 | 3 | 0 | 3 |
| MEG3 | TMEM100 | 0.685641 | 3 | 0 | 3 |
| MEG3 | AGTR1 | 0.685317 | 3 | 0 | 3 |
| MEG3 | KCNJ8 | 0.683943 | 3 | 0 | 3 |
| MEG3 | COLEC12 | 0.680851 | 4 | 0 | 4 |
| MEG3 | TNFRSF19 | 0.678522 | 3 | 0 | 3 |
| MEG3 | C11orf96 | 0.675344 | 4 | 0 | 4 |
| MEG3 | SYT11 | 0.671943 | 4 | 0 | 4 |
| MEG3 | CPQ | 0.670897 | 4 | 0 | 4 |
| MEG3 | TBX5 | 0.66613 | 3 | 0 | 3 |
| MEG3 | METRNL | 0.664142 | 3 | 0 | 3 |
| MEG3 | ANK2 | 0.659122 | 5 | 0 | 4 |
| MEG3 | VASN | 0.652782 | 4 | 0 | 3 |
| MEG3 | HSPB2 | 0.649041 | 4 | 0 | 3 |
For details and further investigation, click here
