METTL4

 

Full name: methyltransferase like 4 Alias Symbol: FLJ23017|HsT661
Type: protein-coding gene Cytoband: 18p11.32
Entrez ID: 64863 HGNC ID: HGNC:24726 Ensembl Gene: ENSG00000101574 OMIM ID: 
Drug and gene relationship at DGIdb

 

Expression of METTL4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 METTL4 64863 219698_s_at 0.5601 0.2824
GSE20347 METTL4 64863 219698_s_at 0.5850 0.0005
GSE23400 METTL4 64863 219698_s_at 0.5358 0.0000
GSE26886 METTL4 64863 219698_s_at 0.1122 0.6303
GSE29001 METTL4 64863 219698_s_at 0.9964 0.0016
GSE38129 METTL4 64863 219698_s_at 0.6733 0.0000
GSE45670 METTL4 64863 219698_s_at 0.6407 0.0003
GSE53622 METTL4 64863 121567 0.1398 0.1158
GSE53624 METTL4 64863 121567 0.4688 0.0000
GSE63941 METTL4 64863 219698_s_at 1.1913 0.0612
GSE77861 METTL4 64863 219698_s_at 0.3445 0.1751
GSE97050 METTL4 64863 A_33_P3315425 0.0527 0.8316
SRP007169 METTL4 64863 RNAseq 1.1848 0.0037
SRP008496 METTL4 64863 RNAseq 0.7489 0.0134
SRP064894 METTL4 64863 RNAseq 0.9659 0.0003
SRP133303 METTL4 64863 RNAseq 0.6323 0.0000
SRP159526 METTL4 64863 RNAseq 0.3351 0.2805
SRP193095 METTL4 64863 RNAseq 0.3210 0.0025
SRP219564 METTL4 64863 RNAseq 0.1321 0.5956
TCGA METTL4 64863 RNAseq 0.1985 0.0115

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by METTL4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of METTL4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 METTL4 64863 7 3 20
GSE20123 METTL4 64863 7 3 20
GSE43470 METTL4 64863 2 5 36
GSE46452 METTL4 64863 3 20 36
GSE47630 METTL4 64863 7 18 15
GSE54993 METTL4 64863 6 3 61
GSE54994 METTL4 64863 12 8 33
GSE60625 METTL4 64863 0 4 7
GSE74703 METTL4 64863 2 3 31
GSE74704 METTL4 64863 5 2 13
TCGA METTL4 64863 36 17 43

Total number of gains: 87; Total number of losses: 86; Total Number of normals: 315.  

 

Somatic mutations of METTL4:

 

Generating mutation plots.

 

Highly correlated genes for METTL4:

 

Showing top 20/185 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
METTL4NPW0.779894303
METTL4TANK0.725073404
METTL4RWDD30.632984404
METTL4ERI10.630534403
METTL4HOXC90.629443403
METTL4RAG20.623127403
METTL4PAPOLA0.621781604
METTL4NPL0.621511503
METTL4MARVELD30.619885504
METTL4LRR10.61615504
METTL4DLGAP50.615013807
METTL4COL27A10.61117504
METTL4CBX30.607311906
METTL4MTERF10.605753705
METTL4LAMA50.604858504
METTL4IL12RB20.604039403
METTL4PDCL0.603351503
METTL4UBXN2B0.599055403
METTL4ARHGAP210.597247503
METTL4IRF60.595381404

For details and further investigation, click here