ERI1

 

Full name: exoribonuclease 1 Alias Symbol: 3'HEXO
Type: protein-coding gene Cytoband: 8p23.1
Entrez ID: 90459 HGNC ID: HGNC:23994 Ensembl Gene: ENSG00000104626 OMIM ID: 608739
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of ERI1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ERI1 90459 226416_at 0.4016 0.3696
GSE26886 ERI1 90459 226416_at -0.2246 0.5161
GSE45670 ERI1 90459 226416_at 0.3718 0.0050
GSE53622 ERI1 90459 19033 0.3141 0.0000
GSE53624 ERI1 90459 19033 0.3776 0.0000
GSE63941 ERI1 90459 226416_at -0.6071 0.5045
GSE77861 ERI1 90459 226416_at 0.3327 0.4460
GSE97050 ERI1 90459 A_33_P3315504 0.0519 0.8444
SRP007169 ERI1 90459 RNAseq 0.4782 0.3113
SRP008496 ERI1 90459 RNAseq 0.3178 0.3116
SRP064894 ERI1 90459 RNAseq 0.4298 0.0419
SRP133303 ERI1 90459 RNAseq 0.4398 0.0040
SRP159526 ERI1 90459 RNAseq 0.3158 0.2649
SRP193095 ERI1 90459 RNAseq 0.1653 0.2380
SRP219564 ERI1 90459 RNAseq 0.3432 0.3068
TCGA ERI1 90459 RNAseq 0.1052 0.0973

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by ERI1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ERI1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ERI1 90459 4 10 16
GSE20123 ERI1 90459 4 10 16
GSE43470 ERI1 90459 4 9 30
GSE46452 ERI1 90459 12 14 33
GSE47630 ERI1 90459 10 7 23
GSE54993 ERI1 90459 3 14 53
GSE54994 ERI1 90459 9 18 26
GSE60625 ERI1 90459 3 0 8
GSE74703 ERI1 90459 4 7 25
GSE74704 ERI1 90459 3 7 10
TCGA ERI1 90459 13 40 43

Total number of gains: 69; Total number of losses: 136; Total Number of normals: 283.  

 

Somatic mutations of ERI1:

 

Generating mutation plots.

 

Highly correlated genes for ERI1:

 

Showing top 20/108 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ERI1DPM30.721778303
ERI1RWDD30.708175303
ERI1UBE2S0.707944303
ERI1FEN10.694251303
ERI1BCL2L120.690218404
ERI1LRR10.679088504
ERI1FUT10.675925303
ERI1CDC60.667432403
ERI1GEMIN20.665697403
ERI1PRMT30.66303403
ERI1CDC25C0.660804303
ERI1HMGA20.658888303
ERI1GBP50.649633404
ERI1HNRNPA2B10.640971303
ERI1CDK160.635245303
ERI1PPIH0.632641403
ERI1POLE20.630878403
ERI1METTL40.630534403
ERI1RPS6KA10.628469303
ERI1BUB1B0.627308403

For details and further investigation, click here