| Full name: poly(A) polymerase alpha | Alias Symbol: PAP | ||
| Type: protein-coding gene | Cytoband: 14q32.2 | ||
| Entrez ID: 10914 | HGNC ID: HGNC:14981 | Ensembl Gene: ENSG00000090060 | OMIM ID: 605553 |
| Drug and gene relationship at DGIdb | |||
Expression of PAPOLA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PAPOLA | 10914 | 212718_at | 0.4738 | 0.0517 | |
| GSE20347 | PAPOLA | 10914 | 212718_at | 0.2406 | 0.1239 | |
| GSE23400 | PAPOLA | 10914 | 212718_at | 0.4777 | 0.0000 | |
| GSE26886 | PAPOLA | 10914 | 212718_at | 0.1390 | 0.5292 | |
| GSE29001 | PAPOLA | 10914 | 212718_at | 0.3026 | 0.1646 | |
| GSE38129 | PAPOLA | 10914 | 212718_at | 0.2828 | 0.0071 | |
| GSE45670 | PAPOLA | 10914 | 212718_at | 0.2628 | 0.0085 | |
| GSE53622 | PAPOLA | 10914 | 69997 | 0.5074 | 0.0000 | |
| GSE53624 | PAPOLA | 10914 | 69997 | 0.4627 | 0.0000 | |
| GSE63941 | PAPOLA | 10914 | 212718_at | 0.5175 | 0.0380 | |
| GSE77861 | PAPOLA | 10914 | 212718_at | 0.3044 | 0.2231 | |
| GSE97050 | PAPOLA | 10914 | A_23_P376239 | 0.6609 | 0.1227 | |
| SRP007169 | PAPOLA | 10914 | RNAseq | 0.2876 | 0.4603 | |
| SRP008496 | PAPOLA | 10914 | RNAseq | 0.3457 | 0.0773 | |
| SRP064894 | PAPOLA | 10914 | RNAseq | 0.0544 | 0.7435 | |
| SRP133303 | PAPOLA | 10914 | RNAseq | 0.3919 | 0.0001 | |
| SRP159526 | PAPOLA | 10914 | RNAseq | 0.1413 | 0.4176 | |
| SRP193095 | PAPOLA | 10914 | RNAseq | -0.0963 | 0.2382 | |
| SRP219564 | PAPOLA | 10914 | RNAseq | -0.0801 | 0.8221 | |
| TCGA | PAPOLA | 10914 | RNAseq | 0.0322 | 0.4187 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PAPOLA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PAPOLA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PAPOLA | 10914 | 10 | 4 | 16 | |
| GSE20123 | PAPOLA | 10914 | 10 | 3 | 17 | |
| GSE43470 | PAPOLA | 10914 | 9 | 3 | 31 | |
| GSE46452 | PAPOLA | 10914 | 17 | 3 | 39 | |
| GSE47630 | PAPOLA | 10914 | 11 | 8 | 21 | |
| GSE54993 | PAPOLA | 10914 | 3 | 8 | 59 | |
| GSE54994 | PAPOLA | 10914 | 21 | 4 | 28 | |
| GSE60625 | PAPOLA | 10914 | 0 | 2 | 9 | |
| GSE74703 | PAPOLA | 10914 | 7 | 3 | 26 | |
| GSE74704 | PAPOLA | 10914 | 6 | 3 | 11 | |
| TCGA | PAPOLA | 10914 | 30 | 19 | 47 |
Total number of gains: 124; Total number of losses: 60; Total Number of normals: 304.
Somatic mutations of PAPOLA:
Generating mutation plots.
Highly correlated genes for PAPOLA:
Showing top 20/873 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PAPOLA | BMS1 | 0.730163 | 4 | 0 | 4 |
| PAPOLA | FAM91A1 | 0.691946 | 6 | 0 | 5 |
| PAPOLA | NDUFB9 | 0.675671 | 6 | 0 | 5 |
| PAPOLA | POM121 | 0.669916 | 3 | 0 | 3 |
| PAPOLA | EME1 | 0.669127 | 3 | 0 | 3 |
| PAPOLA | BTF3L4 | 0.666208 | 4 | 0 | 4 |
| PAPOLA | YTHDF1 | 0.664537 | 6 | 0 | 5 |
| PAPOLA | UBE2E3 | 0.664155 | 6 | 0 | 5 |
| PAPOLA | VRK1 | 0.664019 | 12 | 0 | 11 |
| PAPOLA | RPN1 | 0.663852 | 7 | 0 | 6 |
| PAPOLA | CMSS1 | 0.662205 | 6 | 0 | 6 |
| PAPOLA | LRR1 | 0.659709 | 5 | 0 | 5 |
| PAPOLA | AHSA1 | 0.654166 | 9 | 0 | 8 |
| PAPOLA | HAT1 | 0.649674 | 8 | 0 | 7 |
| PAPOLA | ARL6IP6 | 0.64899 | 5 | 0 | 4 |
| PAPOLA | C14orf119 | 0.645404 | 4 | 0 | 3 |
| PAPOLA | NTMT1 | 0.645256 | 4 | 0 | 4 |
| PAPOLA | TAF2 | 0.636203 | 9 | 0 | 8 |
| PAPOLA | DCAF13 | 0.634691 | 7 | 0 | 5 |
| PAPOLA | AREL1 | 0.631448 | 6 | 0 | 5 |
For details and further investigation, click here
