| Full name: N-acetylneuraminate pyruvate lyase | Alias Symbol: NPL1|DHDPS1 | ||
| Type: protein-coding gene | Cytoband: 1q25.3 | ||
| Entrez ID: 80896 | HGNC ID: HGNC:16781 | Ensembl Gene: ENSG00000135838 | OMIM ID: 611412 |
| Drug and gene relationship at DGIdb | |||
Expression of NPL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NPL | 80896 | 223405_at | 0.7751 | 0.1852 | |
| GSE20347 | NPL | 80896 | 221210_s_at | 0.5532 | 0.1846 | |
| GSE23400 | NPL | 80896 | 221210_s_at | 0.7346 | 0.0000 | |
| GSE26886 | NPL | 80896 | 223405_at | -0.1898 | 0.5898 | |
| GSE29001 | NPL | 80896 | 221210_s_at | 0.8445 | 0.1565 | |
| GSE38129 | NPL | 80896 | 221210_s_at | 1.0477 | 0.0034 | |
| GSE45670 | NPL | 80896 | 223405_at | 0.6812 | 0.0657 | |
| GSE53622 | NPL | 80896 | 88180 | 0.8961 | 0.0000 | |
| GSE53624 | NPL | 80896 | 88180 | 0.4466 | 0.0000 | |
| GSE63941 | NPL | 80896 | 223405_at | 0.9335 | 0.1539 | |
| GSE77861 | NPL | 80896 | 223405_at | 0.8902 | 0.0855 | |
| GSE97050 | NPL | 80896 | A_33_P3414903 | -0.1776 | 0.4107 | |
| SRP007169 | NPL | 80896 | RNAseq | 1.5390 | 0.0018 | |
| SRP008496 | NPL | 80896 | RNAseq | 1.0964 | 0.0026 | |
| SRP064894 | NPL | 80896 | RNAseq | 0.5786 | 0.0130 | |
| SRP133303 | NPL | 80896 | RNAseq | 0.5885 | 0.0427 | |
| SRP159526 | NPL | 80896 | RNAseq | 1.7506 | 0.0008 | |
| SRP193095 | NPL | 80896 | RNAseq | 0.3698 | 0.0884 | |
| SRP219564 | NPL | 80896 | RNAseq | 0.4816 | 0.3916 | |
| TCGA | NPL | 80896 | RNAseq | 0.4837 | 0.0002 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by NPL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NPL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NPL | 80896 | 12 | 0 | 18 | |
| GSE20123 | NPL | 80896 | 12 | 0 | 18 | |
| GSE43470 | NPL | 80896 | 7 | 1 | 35 | |
| GSE46452 | NPL | 80896 | 3 | 1 | 55 | |
| GSE47630 | NPL | 80896 | 14 | 0 | 26 | |
| GSE54993 | NPL | 80896 | 0 | 6 | 64 | |
| GSE54994 | NPL | 80896 | 15 | 0 | 38 | |
| GSE60625 | NPL | 80896 | 0 | 0 | 11 | |
| GSE74703 | NPL | 80896 | 7 | 1 | 28 | |
| GSE74704 | NPL | 80896 | 5 | 0 | 15 | |
| TCGA | NPL | 80896 | 40 | 3 | 53 |
Total number of gains: 115; Total number of losses: 12; Total Number of normals: 361.
Somatic mutations of NPL:
Generating mutation plots.
Highly correlated genes for NPL:
Showing top 20/90 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NPL | NPW | 0.783002 | 3 | 0 | 3 |
| NPL | ZNF572 | 0.765172 | 3 | 0 | 3 |
| NPL | PKP1 | 0.684521 | 3 | 0 | 3 |
| NPL | KIF26B | 0.679997 | 3 | 0 | 3 |
| NPL | CCDC43 | 0.667721 | 3 | 0 | 3 |
| NPL | MDC1 | 0.65831 | 3 | 0 | 3 |
| NPL | KLRG2 | 0.640303 | 4 | 0 | 4 |
| NPL | HOXC9 | 0.638786 | 4 | 0 | 4 |
| NPL | SIRPA | 0.638538 | 4 | 0 | 3 |
| NPL | CES3 | 0.621688 | 4 | 0 | 3 |
| NPL | METTL4 | 0.621511 | 5 | 0 | 3 |
| NPL | CEP19 | 0.6195 | 6 | 0 | 4 |
| NPL | TANK | 0.618615 | 7 | 0 | 5 |
| NPL | CECR2 | 0.613427 | 6 | 0 | 4 |
| NPL | OSBPL11 | 0.60933 | 5 | 0 | 3 |
| NPL | FERMT1 | 0.606364 | 6 | 0 | 5 |
| NPL | ZDHHC23 | 0.604436 | 5 | 0 | 3 |
| NPL | ALOX12B | 0.600273 | 5 | 0 | 3 |
| NPL | WDR53 | 0.598474 | 4 | 0 | 4 |
| NPL | BAALC | 0.593681 | 4 | 0 | 3 |
For details and further investigation, click here
