| Full name: secreted frizzled related protein 2 | Alias Symbol: SARP1|SDF-5|FRP-2 | ||
| Type: protein-coding gene | Cytoband: 4q31.3 | ||
| Entrez ID: 6423 | HGNC ID: HGNC:10777 | Ensembl Gene: ENSG00000145423 | OMIM ID: 604157 |
| Drug and gene relationship at DGIdb | |||
SFRP2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04310 | Wnt signaling pathway |
Expression of SFRP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SFRP2 | 6423 | 223122_s_at | -1.1904 | 0.3202 | |
| GSE26886 | SFRP2 | 6423 | 223122_s_at | 1.7169 | 0.0484 | |
| GSE45670 | SFRP2 | 6423 | 223122_s_at | -3.1950 | 0.0002 | |
| GSE53622 | SFRP2 | 6423 | 14786 | -0.1056 | 0.6720 | |
| GSE53624 | SFRP2 | 6423 | 14786 | 0.4732 | 0.0153 | |
| GSE63941 | SFRP2 | 6423 | 223121_s_at | -0.5975 | 0.0016 | |
| GSE77861 | SFRP2 | 6423 | 223121_s_at | -0.1162 | 0.6741 | |
| GSE97050 | SFRP2 | 6423 | A_23_P81103 | 1.0449 | 0.0555 | |
| SRP007169 | SFRP2 | 6423 | RNAseq | 2.5649 | 0.0000 | |
| SRP008496 | SFRP2 | 6423 | RNAseq | 3.2618 | 0.0000 | |
| SRP064894 | SFRP2 | 6423 | RNAseq | 1.2544 | 0.0065 | |
| SRP133303 | SFRP2 | 6423 | RNAseq | 0.0877 | 0.8505 | |
| SRP159526 | SFRP2 | 6423 | RNAseq | 0.0660 | 0.9222 | |
| SRP219564 | SFRP2 | 6423 | RNAseq | 1.8261 | 0.0080 | |
| TCGA | SFRP2 | 6423 | RNAseq | 0.1533 | 0.3359 |
Upregulated datasets: 5; Downregulated datasets: 1.
Survival by SFRP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SFRP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SFRP2 | 6423 | 0 | 14 | 16 | |
| GSE20123 | SFRP2 | 6423 | 0 | 14 | 16 | |
| GSE43470 | SFRP2 | 6423 | 0 | 13 | 30 | |
| GSE46452 | SFRP2 | 6423 | 1 | 36 | 22 | |
| GSE47630 | SFRP2 | 6423 | 0 | 23 | 17 | |
| GSE54993 | SFRP2 | 6423 | 10 | 0 | 60 | |
| GSE54994 | SFRP2 | 6423 | 1 | 13 | 39 | |
| GSE60625 | SFRP2 | 6423 | 0 | 1 | 10 | |
| GSE74703 | SFRP2 | 6423 | 0 | 11 | 25 | |
| GSE74704 | SFRP2 | 6423 | 0 | 7 | 13 | |
| TCGA | SFRP2 | 6423 | 10 | 35 | 51 |
Total number of gains: 22; Total number of losses: 167; Total Number of normals: 299.
Somatic mutations of SFRP2:
Generating mutation plots.
Highly correlated genes for SFRP2:
Showing top 20/394 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SFRP2 | COL1A2 | 0.762106 | 4 | 0 | 3 |
| SFRP2 | DCN | 0.735101 | 7 | 0 | 6 |
| SFRP2 | ADH1B | 0.72246 | 3 | 0 | 3 |
| SFRP2 | FBN1 | 0.719518 | 5 | 0 | 4 |
| SFRP2 | PDE7B | 0.71305 | 4 | 0 | 4 |
| SFRP2 | FAM13C | 0.712972 | 3 | 0 | 3 |
| SFRP2 | SPON1 | 0.711851 | 8 | 0 | 7 |
| SFRP2 | CTSK | 0.684909 | 8 | 0 | 6 |
| SFRP2 | OLFML3 | 0.680723 | 9 | 0 | 7 |
| SFRP2 | DAB2 | 0.676776 | 7 | 0 | 6 |
| SFRP2 | OLFML1 | 0.676434 | 8 | 0 | 7 |
| SFRP2 | COL1A1 | 0.674313 | 4 | 0 | 3 |
| SFRP2 | CCDC80 | 0.67399 | 6 | 0 | 5 |
| SFRP2 | SERPINF1 | 0.67387 | 7 | 0 | 6 |
| SFRP2 | ABCA8 | 0.670592 | 3 | 0 | 3 |
| SFRP2 | ARHGAP29 | 0.668301 | 3 | 0 | 3 |
| SFRP2 | HEPH | 0.666021 | 7 | 0 | 6 |
| SFRP2 | CNRIP1 | 0.664248 | 8 | 0 | 6 |
| SFRP2 | RNASE6 | 0.661902 | 3 | 0 | 3 |
| SFRP2 | CNN1 | 0.660184 | 3 | 0 | 3 |
For details and further investigation, click here
