| Full name: matrix Gla protein | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12p12.3 | ||
| Entrez ID: 4256 | HGNC ID: HGNC:7060 | Ensembl Gene: ENSG00000111341 | OMIM ID: 154870 |
| Drug and gene relationship at DGIdb | |||
Expression of MGP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MGP | 4256 | 202291_s_at | -1.2908 | 0.3313 | |
| GSE20347 | MGP | 4256 | 202291_s_at | -0.0198 | 0.9805 | |
| GSE23400 | MGP | 4256 | 202291_s_at | -0.4226 | 0.1296 | |
| GSE26886 | MGP | 4256 | 202291_s_at | 2.0540 | 0.0025 | |
| GSE29001 | MGP | 4256 | 202291_s_at | 0.1014 | 0.8800 | |
| GSE38129 | MGP | 4256 | 202291_s_at | -0.4268 | 0.6053 | |
| GSE45670 | MGP | 4256 | 202291_s_at | -3.4096 | 0.0000 | |
| GSE53622 | MGP | 4256 | 55918 | -1.1779 | 0.0000 | |
| GSE53624 | MGP | 4256 | 55918 | -0.9369 | 0.0000 | |
| GSE63941 | MGP | 4256 | 202291_s_at | -5.2020 | 0.0002 | |
| GSE77861 | MGP | 4256 | 202291_s_at | 1.5086 | 0.0347 | |
| GSE97050 | MGP | 4256 | A_23_P204286 | -1.0653 | 0.1819 | |
| SRP007169 | MGP | 4256 | RNAseq | 2.9463 | 0.0000 | |
| SRP008496 | MGP | 4256 | RNAseq | 3.4075 | 0.0000 | |
| SRP064894 | MGP | 4256 | RNAseq | 0.7939 | 0.1550 | |
| SRP133303 | MGP | 4256 | RNAseq | -0.9448 | 0.0790 | |
| SRP159526 | MGP | 4256 | RNAseq | 0.8051 | 0.0989 | |
| SRP193095 | MGP | 4256 | RNAseq | 0.9228 | 0.0186 | |
| SRP219564 | MGP | 4256 | RNAseq | -0.2274 | 0.8439 | |
| TCGA | MGP | 4256 | RNAseq | -0.4648 | 0.0021 |
Upregulated datasets: 4; Downregulated datasets: 3.
Survival by MGP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MGP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MGP | 4256 | 6 | 2 | 22 | |
| GSE20123 | MGP | 4256 | 6 | 2 | 22 | |
| GSE43470 | MGP | 4256 | 9 | 4 | 30 | |
| GSE46452 | MGP | 4256 | 10 | 1 | 48 | |
| GSE47630 | MGP | 4256 | 14 | 1 | 25 | |
| GSE54993 | MGP | 4256 | 1 | 9 | 60 | |
| GSE54994 | MGP | 4256 | 10 | 2 | 41 | |
| GSE60625 | MGP | 4256 | 0 | 1 | 10 | |
| GSE74703 | MGP | 4256 | 9 | 3 | 24 | |
| GSE74704 | MGP | 4256 | 4 | 1 | 15 | |
| TCGA | MGP | 4256 | 41 | 5 | 50 |
Total number of gains: 110; Total number of losses: 31; Total Number of normals: 347.
Somatic mutations of MGP:
Generating mutation plots.
Highly correlated genes for MGP:
Showing top 20/1064 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MGP | A2M | 0.818888 | 13 | 0 | 13 |
| MGP | ACTA2 | 0.806477 | 13 | 0 | 13 |
| MGP | MIR100HG | 0.785137 | 6 | 0 | 6 |
| MGP | MRVI1 | 0.776615 | 8 | 0 | 8 |
| MGP | JAM3 | 0.768878 | 13 | 0 | 13 |
| MGP | PLN | 0.768852 | 13 | 0 | 12 |
| MGP | RSPO3 | 0.762456 | 9 | 0 | 9 |
| MGP | TAGLN | 0.762181 | 12 | 0 | 12 |
| MGP | MYLK | 0.761236 | 13 | 0 | 13 |
| MGP | SMOC2 | 0.760037 | 7 | 0 | 7 |
| MGP | MAGI2-AS3 | 0.757266 | 6 | 0 | 5 |
| MGP | ACTG2 | 0.754495 | 13 | 0 | 13 |
| MGP | JAM2 | 0.753445 | 11 | 0 | 11 |
| MGP | PDLIM3 | 0.751112 | 13 | 0 | 12 |
| MGP | FERMT2 | 0.751088 | 13 | 0 | 13 |
| MGP | TUBA1A | 0.751068 | 9 | 0 | 9 |
| MGP | TTC7B | 0.748216 | 3 | 0 | 3 |
| MGP | CELF2 | 0.747921 | 10 | 0 | 10 |
| MGP | PDE1A | 0.746037 | 11 | 0 | 10 |
| MGP | ANXA6 | 0.746023 | 12 | 0 | 12 |
For details and further investigation, click here
