| Full name: alpha-2-macroglobulin | Alias Symbol: FWP007|S863-7|CPAMD5 | ||
| Type: protein-coding gene | Cytoband: 12p13.31 | ||
| Entrez ID: 2 | HGNC ID: HGNC:7 | Ensembl Gene: ENSG00000175899 | OMIM ID: 103950 |
| Drug and gene relationship at DGIdb | |||
A2M involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04610 | Complement and coagulation cascades |
Expression of A2M:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | A2M | 2 | 217757_at | -1.0353 | 0.2733 | |
| GSE20347 | A2M | 2 | 217757_at | -0.0796 | 0.7699 | |
| GSE23400 | A2M | 2 | 217757_at | -0.2689 | 0.1522 | |
| GSE26886 | A2M | 2 | 217757_at | 0.6761 | 0.2080 | |
| GSE29001 | A2M | 2 | 217757_at | -0.0420 | 0.9580 | |
| GSE38129 | A2M | 2 | 217757_at | -0.3720 | 0.3352 | |
| GSE45670 | A2M | 2 | 217757_at | -1.7511 | 0.0003 | |
| GSE53622 | A2M | 2 | 71580 | -1.0111 | 0.0000 | |
| GSE53624 | A2M | 2 | 71580 | -0.9191 | 0.0000 | |
| GSE63941 | A2M | 2 | 217757_at | -4.1735 | 0.0002 | |
| GSE77861 | A2M | 2 | 217757_at | 0.7024 | 0.1505 | |
| GSE97050 | A2M | 2 | A_23_P116898 | 0.0332 | 0.9500 | |
| SRP007169 | A2M | 2 | RNAseq | 1.3224 | 0.0042 | |
| SRP008496 | A2M | 2 | RNAseq | 1.2264 | 0.0003 | |
| SRP064894 | A2M | 2 | RNAseq | 0.6645 | 0.1106 | |
| SRP133303 | A2M | 2 | RNAseq | -0.8147 | 0.0261 | |
| SRP159526 | A2M | 2 | RNAseq | 0.4054 | 0.2805 | |
| SRP193095 | A2M | 2 | RNAseq | 0.4705 | 0.1197 | |
| SRP219564 | A2M | 2 | RNAseq | 0.2714 | 0.7618 | |
| TCGA | A2M | 2 | RNAseq | -0.3543 | 0.0001 |
Upregulated datasets: 2; Downregulated datasets: 3.
Survival by A2M expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of A2M:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | A2M | 2 | 6 | 3 | 21 | |
| GSE20123 | A2M | 2 | 6 | 3 | 21 | |
| GSE43470 | A2M | 2 | 8 | 5 | 30 | |
| GSE46452 | A2M | 2 | 10 | 1 | 48 | |
| GSE47630 | A2M | 2 | 12 | 2 | 26 | |
| GSE54993 | A2M | 2 | 1 | 10 | 59 | |
| GSE54994 | A2M | 2 | 9 | 2 | 42 | |
| GSE60625 | A2M | 2 | 0 | 1 | 10 | |
| GSE74703 | A2M | 2 | 8 | 3 | 25 | |
| GSE74704 | A2M | 2 | 4 | 2 | 14 | |
| TCGA | A2M | 2 | 40 | 6 | 50 |
Total number of gains: 104; Total number of losses: 38; Total Number of normals: 346.
Somatic mutations of A2M:
Generating mutation plots.
Highly correlated genes for A2M:
Showing top 20/1070 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| A2M | MGP | 0.818888 | 13 | 0 | 13 |
| A2M | MRVI1 | 0.776034 | 8 | 0 | 8 |
| A2M | FGF7 | 0.774262 | 8 | 0 | 8 |
| A2M | SMPD1 | 0.767083 | 4 | 0 | 4 |
| A2M | JAM3 | 0.766636 | 13 | 0 | 13 |
| A2M | MGAT5 | 0.761874 | 3 | 0 | 3 |
| A2M | CNRIP1 | 0.760627 | 9 | 0 | 9 |
| A2M | ACTA2 | 0.757676 | 13 | 0 | 12 |
| A2M | GNG11 | 0.756738 | 13 | 0 | 12 |
| A2M | TAGLN | 0.754124 | 11 | 0 | 11 |
| A2M | CLEC14A | 0.753434 | 6 | 0 | 6 |
| A2M | ZNF347 | 0.752119 | 3 | 0 | 3 |
| A2M | CLEC3B | 0.748265 | 3 | 0 | 3 |
| A2M | ACKR1 | 0.746357 | 8 | 0 | 7 |
| A2M | DDR2 | 0.744754 | 12 | 0 | 12 |
| A2M | RNF14 | 0.743103 | 3 | 0 | 3 |
| A2M | GNG7 | 0.742887 | 6 | 0 | 6 |
| A2M | AOC3 | 0.74276 | 13 | 0 | 12 |
| A2M | ACTG2 | 0.740639 | 13 | 0 | 13 |
| A2M | FILIP1L | 0.738123 | 13 | 0 | 12 |
For details and further investigation, click here
