| Full name: growth hormone receptor | Alias Symbol: GHBP | ||
| Type: protein-coding gene | Cytoband: 5p13.1-p12 | ||
| Entrez ID: 2690 | HGNC ID: HGNC:4263 | Ensembl Gene: ENSG00000112964 | OMIM ID: 600946 |
| Drug and gene relationship at DGIdb | |||
GHR involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04630 | Jak-STAT signaling pathway |
Expression of GHR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GHR | 2690 | 205498_at | 0.0489 | 0.9767 | |
| GSE20347 | GHR | 2690 | 205498_at | -0.3451 | 0.5101 | |
| GSE23400 | GHR | 2690 | 205498_at | 0.0044 | 0.9781 | |
| GSE26886 | GHR | 2690 | 205498_at | 0.2036 | 0.7850 | |
| GSE29001 | GHR | 2690 | 205498_at | -1.1870 | 0.0373 | |
| GSE38129 | GHR | 2690 | 205498_at | -1.0556 | 0.0106 | |
| GSE45670 | GHR | 2690 | 205498_at | -1.1565 | 0.0287 | |
| GSE53622 | GHR | 2690 | 64170 | -0.8047 | 0.0000 | |
| GSE53624 | GHR | 2690 | 45041 | -0.6151 | 0.0005 | |
| GSE63941 | GHR | 2690 | 205498_at | -3.0545 | 0.0212 | |
| GSE77861 | GHR | 2690 | 205498_at | 0.0903 | 0.8624 | |
| GSE97050 | GHR | 2690 | A_33_P3260733 | -0.5710 | 0.1367 | |
| SRP007169 | GHR | 2690 | RNAseq | 1.1905 | 0.1577 | |
| SRP064894 | GHR | 2690 | RNAseq | -0.6778 | 0.0360 | |
| SRP133303 | GHR | 2690 | RNAseq | -0.8313 | 0.0002 | |
| SRP159526 | GHR | 2690 | RNAseq | -0.2276 | 0.6753 | |
| SRP193095 | GHR | 2690 | RNAseq | -0.2473 | 0.3462 | |
| SRP219564 | GHR | 2690 | RNAseq | 0.1179 | 0.8137 | |
| TCGA | GHR | 2690 | RNAseq | -0.6698 | 0.0023 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by GHR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GHR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GHR | 2690 | 10 | 0 | 20 | |
| GSE20123 | GHR | 2690 | 10 | 0 | 20 | |
| GSE43470 | GHR | 2690 | 17 | 0 | 26 | |
| GSE46452 | GHR | 2690 | 5 | 22 | 32 | |
| GSE47630 | GHR | 2690 | 6 | 12 | 22 | |
| GSE54993 | GHR | 2690 | 6 | 3 | 61 | |
| GSE54994 | GHR | 2690 | 24 | 2 | 27 | |
| GSE60625 | GHR | 2690 | 0 | 0 | 11 | |
| GSE74703 | GHR | 2690 | 13 | 0 | 23 | |
| GSE74704 | GHR | 2690 | 9 | 0 | 11 | |
| TCGA | GHR | 2690 | 52 | 5 | 39 |
Total number of gains: 152; Total number of losses: 44; Total Number of normals: 292.
Somatic mutations of GHR:
Generating mutation plots.
Highly correlated genes for GHR:
Showing top 20/243 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GHR | FAM76B | 0.742711 | 3 | 0 | 3 |
| GHR | DEGS1 | 0.724837 | 4 | 0 | 4 |
| GHR | AFF1 | 0.720036 | 3 | 0 | 3 |
| GHR | PGRMC1 | 0.6951 | 3 | 0 | 3 |
| GHR | ZNF22 | 0.692147 | 3 | 0 | 3 |
| GHR | ZNF300 | 0.691822 | 3 | 0 | 3 |
| GHR | NR2F1 | 0.685372 | 3 | 0 | 3 |
| GHR | SLC25A38 | 0.683246 | 3 | 0 | 3 |
| GHR | FBXL17 | 0.682757 | 3 | 0 | 3 |
| GHR | PIP4K2B | 0.679585 | 3 | 0 | 3 |
| GHR | CHST3 | 0.678614 | 3 | 0 | 3 |
| GHR | ABHD2 | 0.677016 | 3 | 0 | 3 |
| GHR | CNST | 0.676181 | 3 | 0 | 3 |
| GHR | ARMC8 | 0.676012 | 3 | 0 | 3 |
| GHR | ECSCR | 0.675709 | 3 | 0 | 3 |
| GHR | ZMAT3 | 0.674978 | 3 | 0 | 3 |
| GHR | NUFIP2 | 0.659489 | 3 | 0 | 3 |
| GHR | ZNF689 | 0.658319 | 3 | 0 | 3 |
| GHR | TCF7L2 | 0.656002 | 4 | 0 | 4 |
| GHR | SEC22C | 0.648974 | 3 | 0 | 3 |
For details and further investigation, click here
