UBR5

 

Full name: ubiquitin protein ligase E3 component n-recognin 5 Alias Symbol: DD5|HYD|EDD|KIAA0896
Type: protein-coding gene Cytoband: 8q22.3
Entrez ID: 51366 HGNC ID: HGNC:16806 Ensembl Gene: ENSG00000104517 OMIM ID: 608413
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of UBR5:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 UBR5 51366 208884_s_at 0.5187 0.1776
GSE20347 UBR5 51366 208882_s_at 0.6357 0.0005
GSE23400 UBR5 51366 208884_s_at 0.4770 0.0000
GSE26886 UBR5 51366 208882_s_at 0.6115 0.0006
GSE29001 UBR5 51366 208882_s_at 0.7122 0.0030
GSE38129 UBR5 51366 208882_s_at 0.5520 0.0001
GSE45670 UBR5 51366 208884_s_at 0.2102 0.1134
GSE53622 UBR5 51366 110700 0.4057 0.0000
GSE53624 UBR5 51366 110700 0.4036 0.0000
GSE63941 UBR5 51366 208884_s_at 0.0608 0.9143
GSE77861 UBR5 51366 208884_s_at 0.3674 0.2553
GSE97050 UBR5 51366 A_32_P159400 0.4286 0.3261
SRP007169 UBR5 51366 RNAseq 1.1749 0.0035
SRP008496 UBR5 51366 RNAseq 1.1207 0.0001
SRP064894 UBR5 51366 RNAseq 0.3112 0.1847
SRP133303 UBR5 51366 RNAseq 0.1660 0.0933
SRP159526 UBR5 51366 RNAseq 0.0272 0.9085
SRP193095 UBR5 51366 RNAseq 0.3078 0.0001
SRP219564 UBR5 51366 RNAseq 0.0869 0.7715
TCGA UBR5 51366 RNAseq 0.0944 0.0332

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by UBR5 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of UBR5:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 UBR5 51366 17 0 13
GSE20123 UBR5 51366 18 0 12
GSE43470 UBR5 51366 22 0 21
GSE46452 UBR5 51366 24 0 35
GSE47630 UBR5 51366 24 0 16
GSE54993 UBR5 51366 0 20 50
GSE54994 UBR5 51366 38 1 14
GSE60625 UBR5 51366 0 4 7
GSE74703 UBR5 51366 19 0 17
GSE74704 UBR5 51366 12 0 8
TCGA UBR5 51366 59 1 36

Total number of gains: 233; Total number of losses: 26; Total Number of normals: 229.  

 

Somatic mutations of UBR5:

 

Generating mutation plots.

 

Highly correlated genes for UBR5:

 

Showing top 20/974 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
UBR5PRKAB20.725616303
UBR5RHOBTB30.720454303
UBR5TMEM1650.709664303
UBR5BPNT10.696057303
UBR5TAF20.68274412011
UBR5MIB10.678146303
UBR5ZNF1210.66872303
UBR5DCAF130.66622411011
UBR5MTERF30.665495807
UBR5FMOD0.661743303
UBR5LAPTM4B0.66123611010
UBR5COPB10.657858403
UBR5TGS10.657667909
UBR5KLHL50.655919303
UBR5FGF110.652962303
UBR5SNCAIP0.651389303
UBR5TMCO10.648206403
UBR5RNMT0.647749403
UBR5NSMCE20.647487806
UBR5ATP6V1C10.64746113011

For details and further investigation, click here