| Full name: WNK lysine deficient protein kinase 1 | Alias Symbol: HSAN2|PPP1R167 | ||
| Type: protein-coding gene | Cytoband: 12p13.33 | ||
| Entrez ID: 65125 | HGNC ID: HGNC:14540 | Ensembl Gene: ENSG00000060237 | OMIM ID: 605232 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of WNK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | WNK1 | 65125 | 211992_at | -0.4318 | 0.2929 | |
| GSE20347 | WNK1 | 65125 | 211992_at | -0.7438 | 0.0000 | |
| GSE23400 | WNK1 | 65125 | 211994_at | -0.7415 | 0.0000 | |
| GSE26886 | WNK1 | 65125 | 211994_at | -1.7263 | 0.0000 | |
| GSE29001 | WNK1 | 65125 | 211994_at | -0.7264 | 0.0299 | |
| GSE38129 | WNK1 | 65125 | 211992_at | -0.7240 | 0.0153 | |
| GSE45670 | WNK1 | 65125 | 211994_at | -0.5017 | 0.0106 | |
| GSE53622 | WNK1 | 65125 | 123033 | -0.6473 | 0.0000 | |
| GSE53624 | WNK1 | 65125 | 123033 | -0.7528 | 0.0000 | |
| GSE63941 | WNK1 | 65125 | 211992_at | 1.9942 | 0.0002 | |
| GSE77861 | WNK1 | 65125 | 211994_at | -0.7964 | 0.0023 | |
| GSE97050 | WNK1 | 65125 | A_33_P3510335 | -0.2258 | 0.6711 | |
| SRP007169 | WNK1 | 65125 | RNAseq | -0.5656 | 0.3054 | |
| SRP008496 | WNK1 | 65125 | RNAseq | -0.1916 | 0.6721 | |
| SRP064894 | WNK1 | 65125 | RNAseq | -1.5967 | 0.0000 | |
| SRP133303 | WNK1 | 65125 | RNAseq | -0.6695 | 0.0008 | |
| SRP159526 | WNK1 | 65125 | RNAseq | -1.3100 | 0.0000 | |
| SRP193095 | WNK1 | 65125 | RNAseq | -1.0100 | 0.0000 | |
| SRP219564 | WNK1 | 65125 | RNAseq | -1.0732 | 0.0062 | |
| TCGA | WNK1 | 65125 | RNAseq | 0.0140 | 0.7851 |
Upregulated datasets: 1; Downregulated datasets: 5.
Survival by WNK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of WNK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | WNK1 | 65125 | 9 | 4 | 17 | |
| GSE20123 | WNK1 | 65125 | 8 | 4 | 18 | |
| GSE43470 | WNK1 | 65125 | 8 | 3 | 32 | |
| GSE46452 | WNK1 | 65125 | 10 | 1 | 48 | |
| GSE47630 | WNK1 | 65125 | 12 | 2 | 26 | |
| GSE54993 | WNK1 | 65125 | 1 | 10 | 59 | |
| GSE54994 | WNK1 | 65125 | 10 | 2 | 41 | |
| GSE60625 | WNK1 | 65125 | 0 | 1 | 10 | |
| GSE74703 | WNK1 | 65125 | 7 | 2 | 27 | |
| GSE74704 | WNK1 | 65125 | 5 | 2 | 13 | |
| TCGA | WNK1 | 65125 | 41 | 7 | 48 |
Total number of gains: 111; Total number of losses: 38; Total Number of normals: 339.
Somatic mutations of WNK1:
Generating mutation plots.
Highly correlated genes for WNK1:
Showing top 20/1194 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| WNK1 | ALG14 | 0.811856 | 3 | 0 | 3 |
| WNK1 | ZNF416 | 0.763251 | 4 | 0 | 3 |
| WNK1 | CCDC6 | 0.747992 | 11 | 0 | 11 |
| WNK1 | SFTA2 | 0.739642 | 4 | 0 | 4 |
| WNK1 | AIF1L | 0.734543 | 7 | 0 | 7 |
| WNK1 | TYSND1 | 0.726343 | 4 | 0 | 4 |
| WNK1 | GYS2 | 0.720663 | 10 | 0 | 10 |
| WNK1 | CIDEB | 0.715146 | 7 | 0 | 7 |
| WNK1 | FOXN1 | 0.714943 | 3 | 0 | 3 |
| WNK1 | ZNF823 | 0.714631 | 5 | 0 | 5 |
| WNK1 | RBM20 | 0.712588 | 5 | 0 | 4 |
| WNK1 | MAMDC4 | 0.712135 | 3 | 0 | 3 |
| WNK1 | PDIK1L | 0.710944 | 3 | 0 | 3 |
| WNK1 | PCBP1-AS1 | 0.710368 | 4 | 0 | 4 |
| WNK1 | BNIPL | 0.710342 | 6 | 0 | 6 |
| WNK1 | ULK3 | 0.707928 | 7 | 0 | 7 |
| WNK1 | UNC5B | 0.706893 | 4 | 0 | 3 |
| WNK1 | PSENEN | 0.702359 | 4 | 0 | 4 |
| WNK1 | PAIP2 | 0.701948 | 3 | 0 | 3 |
| WNK1 | RANBP9 | 0.701804 | 11 | 0 | 10 |
For details and further investigation, click here
