HSP90AA1

 

Full name: heat shock protein 90 alpha family class A member 1 Alias Symbol: Hsp89|Hsp90|FLJ31884|HSP90N
Type: protein-coding gene Cytoband: 14q32.31
Entrez ID: 3320 HGNC ID: HGNC:5253 Ensembl Gene: ENSG00000080824 OMIM ID: 140571
Related drugs: ALVESPIMYCIN, ALVESPIMYCIN HYDROCHLORIDE, CHEMBL2170470, CHEMBL2204502, CHEMBL553939, GANETESPIB, NVP-AUY922, ONALESPIB, RETASPIMYCIN, RETASPIMYCIN HYDROCHLORIDE (CHEMBL377559)... [more]
Screen Evidence:

 

HSP90AA1 involved pathways:

KEGG pathway Description View
hsa04151PI3K-Akt signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa05200Pathways in cancer
hsa05215Prostate cancer

 

Expression of HSP90AA1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 HSP90AA1 3320 211969_at 0.4936 0.0806
GSE20347 HSP90AA1 3320 214328_s_at 0.9167 0.0000
GSE23400 HSP90AA1 3320 214328_s_at 0.8567 0.0000
GSE26886 HSP90AA1 3320 214328_s_at 0.5471 0.0006
GSE29001 HSP90AA1 3320 214328_s_at 0.6528 0.0004
GSE38129 HSP90AA1 3320 214328_s_at 0.7381 0.0000
GSE45670 HSP90AA1 3320 214328_s_at 0.6326 0.0007
GSE53622 HSP90AA1 3320 90410 1.2580 0.0000
GSE53624 HSP90AA1 3320 127490 1.4509 0.0000
GSE63941 HSP90AA1 3320 211969_at 0.6875 0.0260
GSE77861 HSP90AA1 3320 214328_s_at 0.6786 0.0007
GSE97050 HSP90AA1 3320 A_23_P162874 0.9121 0.1281
SRP007169 HSP90AA1 3320 RNAseq 0.1858 0.7810
SRP008496 HSP90AA1 3320 RNAseq 0.3178 0.5176
SRP064894 HSP90AA1 3320 RNAseq 1.1442 0.0000
SRP133303 HSP90AA1 3320 RNAseq 1.3596 0.0000
SRP159526 HSP90AA1 3320 RNAseq 1.6474 0.0006
SRP193095 HSP90AA1 3320 RNAseq 0.5602 0.0014
SRP219564 HSP90AA1 3320 RNAseq 0.2987 0.6898
TCGA HSP90AA1 3320 RNAseq 0.1569 0.0002

Upregulated datasets: 5; Downregulated datasets: 0.  

 

Survival by HSP90AA1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of HSP90AA1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 HSP90AA1 3320 11 5 14
GSE20123 HSP90AA1 3320 10 4 16
GSE43470 HSP90AA1 3320 7 4 32
GSE46452 HSP90AA1 3320 18 4 37
GSE47630 HSP90AA1 3320 10 9 21
GSE54993 HSP90AA1 3320 3 8 59
GSE54994 HSP90AA1 3320 21 4 28
GSE60625 HSP90AA1 3320 0 2 9
GSE74703 HSP90AA1 3320 6 3 27
GSE74704 HSP90AA1 3320 5 3 12
TCGA HSP90AA1 3320 32 19 45

Total number of gains: 123; Total number of losses: 65; Total Number of normals: 300.  

 

Somatic mutations of HSP90AA1:

 

Generating mutation plots.

 

Highly correlated genes for HSP90AA1:

 

Showing top 20/1639 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
HSP90AA1MTERF30.777194808
HSP90AA1FNDC3B0.75202811011
HSP90AA1MMP10.75003611011
HSP90AA1STK30.74794311011
HSP90AA1SERPINH10.74201211010
HSP90AA1PLAU0.73737311011
HSP90AA1CTHRC10.732744707
HSP90AA1HSPH10.72979312011
HSP90AA1HSP90AB10.72878310010
HSP90AA1U2SURP0.728603909
HSP90AA1CBX30.72786610010
HSP90AA1SLC19A10.725228303
HSP90AA1ATP13A30.72442611011
HSP90AA1HSPD10.72091613013
HSP90AA1PLEKHA30.717691303
HSP90AA1TMEM184B0.71595611010
HSP90AA1LPCAT10.71484111011
HSP90AA1MLF10.7141910010
HSP90AA1FMNL20.708451707
HSP90AA1RFC40.70650512012

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