| Full name: protein phosphatase 1 regulatory subunit 3B | Alias Symbol: GL|FLJ14005|PPP1R4 | ||
| Type: protein-coding gene | Cytoband: 8p23.1 | ||
| Entrez ID: 79660 | HGNC ID: HGNC:14942 | Ensembl Gene: ENSG00000173281 | OMIM ID: 610541 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
PPP1R3B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04910 | Insulin signaling pathway | |
| hsa04931 | Insulin resistance |
Expression of PPP1R3B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPP1R3B | 79660 | 222662_at | -1.1637 | 0.0898 | |
| GSE26886 | PPP1R3B | 79660 | 222662_at | -0.9583 | 0.0698 | |
| GSE45670 | PPP1R3B | 79660 | 222662_at | -0.3367 | 0.3816 | |
| GSE53622 | PPP1R3B | 79660 | 10910 | -1.0330 | 0.0000 | |
| GSE53624 | PPP1R3B | 79660 | 10910 | -1.2220 | 0.0000 | |
| GSE63941 | PPP1R3B | 79660 | 222662_at | -1.4477 | 0.1495 | |
| GSE77861 | PPP1R3B | 79660 | 222662_at | -0.4411 | 0.4419 | |
| GSE97050 | PPP1R3B | 79660 | A_24_P201064 | -0.7266 | 0.1417 | |
| SRP007169 | PPP1R3B | 79660 | RNAseq | -1.3020 | 0.0601 | |
| SRP008496 | PPP1R3B | 79660 | RNAseq | -1.5008 | 0.0004 | |
| SRP064894 | PPP1R3B | 79660 | RNAseq | -1.0855 | 0.0000 | |
| SRP133303 | PPP1R3B | 79660 | RNAseq | -0.6867 | 0.0154 | |
| SRP159526 | PPP1R3B | 79660 | RNAseq | -0.6716 | 0.1400 | |
| SRP193095 | PPP1R3B | 79660 | RNAseq | -1.0079 | 0.0000 | |
| SRP219564 | PPP1R3B | 79660 | RNAseq | -0.4297 | 0.3131 | |
| TCGA | PPP1R3B | 79660 | RNAseq | -0.4187 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by PPP1R3B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPP1R3B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPP1R3B | 79660 | 4 | 11 | 15 | |
| GSE20123 | PPP1R3B | 79660 | 4 | 11 | 15 | |
| GSE43470 | PPP1R3B | 79660 | 4 | 9 | 30 | |
| GSE46452 | PPP1R3B | 79660 | 12 | 14 | 33 | |
| GSE47630 | PPP1R3B | 79660 | 10 | 7 | 23 | |
| GSE54993 | PPP1R3B | 79660 | 3 | 14 | 53 | |
| GSE54994 | PPP1R3B | 79660 | 9 | 18 | 26 | |
| GSE60625 | PPP1R3B | 79660 | 3 | 0 | 8 | |
| GSE74703 | PPP1R3B | 79660 | 4 | 7 | 25 | |
| GSE74704 | PPP1R3B | 79660 | 3 | 7 | 10 | |
| TCGA | PPP1R3B | 79660 | 13 | 40 | 43 |
Total number of gains: 69; Total number of losses: 138; Total Number of normals: 281.
Somatic mutations of PPP1R3B:
Generating mutation plots.
Highly correlated genes for PPP1R3B:
Showing top 20/684 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPP1R3B | TBC1D20 | 0.797361 | 3 | 0 | 3 |
| PPP1R3B | RNF185 | 0.785299 | 3 | 0 | 3 |
| PPP1R3B | C7 | 0.763247 | 3 | 0 | 3 |
| PPP1R3B | MLLT10 | 0.744045 | 3 | 0 | 3 |
| PPP1R3B | KCNB1 | 0.743283 | 3 | 0 | 3 |
| PPP1R3B | YTHDC2 | 0.741472 | 4 | 0 | 3 |
| PPP1R3B | NDUFS1 | 0.74042 | 3 | 0 | 3 |
| PPP1R3B | CASQ2 | 0.735737 | 3 | 0 | 3 |
| PPP1R3B | DMXL1 | 0.734764 | 4 | 0 | 4 |
| PPP1R3B | SNX14 | 0.729855 | 3 | 0 | 3 |
| PPP1R3B | FDX1 | 0.72919 | 3 | 0 | 3 |
| PPP1R3B | UBE4B | 0.723387 | 3 | 0 | 3 |
| PPP1R3B | GNG7 | 0.72015 | 3 | 0 | 3 |
| PPP1R3B | SERPINB11 | 0.718502 | 3 | 0 | 3 |
| PPP1R3B | KANK1 | 0.712286 | 4 | 0 | 4 |
| PPP1R3B | ARG2 | 0.711872 | 3 | 0 | 3 |
| PPP1R3B | SAP18 | 0.7088 | 4 | 0 | 4 |
| PPP1R3B | CD34 | 0.708072 | 3 | 0 | 3 |
| PPP1R3B | PPP2CB | 0.704879 | 4 | 0 | 4 |
| PPP1R3B | PPP3CC | 0.704745 | 4 | 0 | 3 |
For details and further investigation, click here
