| Full name: dickkopf WNT signaling pathway inhibitor 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 4q25 | ||
| Entrez ID: 27123 | HGNC ID: HGNC:2892 | Ensembl Gene: ENSG00000155011 | OMIM ID: 605415 |
DKK2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04310 | Wnt signaling pathway |
Expression of DKK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DKK2 | 27123 | 219908_at | 0.5249 | 0.3774 | |
| GSE20347 | DKK2 | 27123 | 219908_at | 0.0451 | 0.7010 | |
| GSE23400 | DKK2 | 27123 | 219908_at | 0.0601 | 0.0284 | |
| GSE26886 | DKK2 | 27123 | 219908_at | -0.1757 | 0.6062 | |
| GSE29001 | DKK2 | 27123 | 219908_at | -0.2646 | 0.3778 | |
| GSE38129 | DKK2 | 27123 | 219908_at | 0.2758 | 0.1188 | |
| GSE45670 | DKK2 | 27123 | 219908_at | -0.2512 | 0.3174 | |
| GSE53622 | DKK2 | 27123 | 9929 | 0.5596 | 0.0000 | |
| GSE53624 | DKK2 | 27123 | 9929 | 0.3673 | 0.0004 | |
| GSE63941 | DKK2 | 27123 | 219908_at | -0.9943 | 0.1765 | |
| GSE77861 | DKK2 | 27123 | 224199_at | 0.0187 | 0.9247 | |
| GSE97050 | DKK2 | 27123 | A_23_P155848 | 0.3437 | 0.1725 | |
| SRP007169 | DKK2 | 27123 | RNAseq | 0.6950 | 0.3266 | |
| SRP133303 | DKK2 | 27123 | RNAseq | 1.9022 | 0.0000 | |
| SRP159526 | DKK2 | 27123 | RNAseq | 2.0610 | 0.0003 | |
| TCGA | DKK2 | 27123 | RNAseq | 0.8116 | 0.0043 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by DKK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DKK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DKK2 | 27123 | 0 | 12 | 18 | |
| GSE20123 | DKK2 | 27123 | 0 | 12 | 18 | |
| GSE43470 | DKK2 | 27123 | 0 | 13 | 30 | |
| GSE46452 | DKK2 | 27123 | 1 | 36 | 22 | |
| GSE47630 | DKK2 | 27123 | 0 | 20 | 20 | |
| GSE54993 | DKK2 | 27123 | 9 | 0 | 61 | |
| GSE54994 | DKK2 | 27123 | 1 | 10 | 42 | |
| GSE60625 | DKK2 | 27123 | 0 | 3 | 8 | |
| GSE74703 | DKK2 | 27123 | 0 | 11 | 25 | |
| GSE74704 | DKK2 | 27123 | 0 | 6 | 14 | |
| TCGA | DKK2 | 27123 | 7 | 36 | 53 |
Total number of gains: 18; Total number of losses: 159; Total Number of normals: 311.
Somatic mutations of DKK2:
Generating mutation plots.
Highly correlated genes for DKK2:
Showing top 20/47 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DKK2 | RAB3B | 0.700444 | 3 | 0 | 3 |
| DKK2 | MMP19 | 0.688602 | 3 | 0 | 3 |
| DKK2 | FFAR2 | 0.678754 | 3 | 0 | 3 |
| DKK2 | SPTA1 | 0.663045 | 3 | 0 | 3 |
| DKK2 | FAM155A-IT1 | 0.656254 | 3 | 0 | 3 |
| DKK2 | EVA1B | 0.652574 | 3 | 0 | 3 |
| DKK2 | HLX | 0.642517 | 5 | 0 | 4 |
| DKK2 | CHSY3 | 0.628997 | 4 | 0 | 3 |
| DKK2 | SLC2A11 | 0.628093 | 3 | 0 | 3 |
| DKK2 | ADAMTS12 | 0.619427 | 4 | 0 | 3 |
| DKK2 | WDR62 | 0.608189 | 3 | 0 | 3 |
| DKK2 | CLDN16 | 0.607227 | 4 | 0 | 4 |
| DKK2 | CPT1C | 0.6064 | 3 | 0 | 3 |
| DKK2 | IQSEC3 | 0.601811 | 3 | 0 | 3 |
| DKK2 | TNFAIP6 | 0.598258 | 4 | 0 | 3 |
| DKK2 | GPR150 | 0.589474 | 4 | 0 | 3 |
| DKK2 | LAYN | 0.585251 | 4 | 0 | 3 |
| DKK2 | NPR2 | 0.58495 | 3 | 0 | 3 |
| DKK2 | ESM1 | 0.584602 | 5 | 0 | 3 |
| DKK2 | ADAM12 | 0.566406 | 5 | 0 | 3 |
For details and further investigation, click here
