| Full name: myosin phosphatase Rho interacting protein | Alias Symbol: RHOIP3|M-RIP|p116Rip | ||
| Type: protein-coding gene | Cytoband: 17p11.2 | ||
| Entrez ID: 23164 | HGNC ID: HGNC:30321 | Ensembl Gene: ENSG00000133030 | OMIM ID: 612935 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of MPRIP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MPRIP | 23164 | 212197_x_at | -0.3819 | 0.1582 | |
| GSE20347 | MPRIP | 23164 | 212197_x_at | -0.5491 | 0.0000 | |
| GSE23400 | MPRIP | 23164 | 212197_x_at | -0.5649 | 0.0000 | |
| GSE26886 | MPRIP | 23164 | 212197_x_at | -1.4188 | 0.0000 | |
| GSE29001 | MPRIP | 23164 | 212197_x_at | -0.8344 | 0.0223 | |
| GSE38129 | MPRIP | 23164 | 212197_x_at | -0.7230 | 0.0000 | |
| GSE45670 | MPRIP | 23164 | 212197_x_at | -0.4375 | 0.0084 | |
| GSE53622 | MPRIP | 23164 | 5719 | -0.9239 | 0.0000 | |
| GSE53624 | MPRIP | 23164 | 5719 | -0.8045 | 0.0000 | |
| GSE63941 | MPRIP | 23164 | 212197_x_at | -0.5444 | 0.5370 | |
| GSE77861 | MPRIP | 23164 | 212197_x_at | -0.4134 | 0.0598 | |
| GSE97050 | MPRIP | 23164 | A_33_P3230526 | -0.3832 | 0.1518 | |
| SRP007169 | MPRIP | 23164 | RNAseq | -0.9882 | 0.0307 | |
| SRP008496 | MPRIP | 23164 | RNAseq | -0.6197 | 0.0272 | |
| SRP064894 | MPRIP | 23164 | RNAseq | -0.2525 | 0.2815 | |
| SRP133303 | MPRIP | 23164 | RNAseq | -0.6666 | 0.0000 | |
| SRP159526 | MPRIP | 23164 | RNAseq | -0.6324 | 0.0093 | |
| SRP193095 | MPRIP | 23164 | RNAseq | -0.5277 | 0.0000 | |
| SRP219564 | MPRIP | 23164 | RNAseq | -0.3669 | 0.2790 | |
| TCGA | MPRIP | 23164 | RNAseq | -0.2426 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by MPRIP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MPRIP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MPRIP | 23164 | 3 | 3 | 24 | |
| GSE20123 | MPRIP | 23164 | 3 | 4 | 23 | |
| GSE43470 | MPRIP | 23164 | 2 | 5 | 36 | |
| GSE46452 | MPRIP | 23164 | 34 | 1 | 24 | |
| GSE47630 | MPRIP | 23164 | 7 | 1 | 32 | |
| GSE54993 | MPRIP | 23164 | 3 | 3 | 64 | |
| GSE54994 | MPRIP | 23164 | 6 | 5 | 42 | |
| GSE60625 | MPRIP | 23164 | 4 | 0 | 7 | |
| GSE74703 | MPRIP | 23164 | 2 | 2 | 32 | |
| GSE74704 | MPRIP | 23164 | 2 | 1 | 17 | |
| TCGA | MPRIP | 23164 | 18 | 23 | 55 |
Total number of gains: 84; Total number of losses: 48; Total Number of normals: 356.
Somatic mutations of MPRIP:
Generating mutation plots.
Highly correlated genes for MPRIP:
Showing top 20/1059 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MPRIP | ZNF662 | 0.737303 | 6 | 0 | 6 |
| MPRIP | GAB1 | 0.723957 | 9 | 0 | 8 |
| MPRIP | FAM219B | 0.712878 | 4 | 0 | 4 |
| MPRIP | PCBP1-AS1 | 0.712207 | 4 | 0 | 4 |
| MPRIP | MYZAP | 0.694855 | 3 | 0 | 3 |
| MPRIP | WWC1 | 0.692754 | 7 | 0 | 7 |
| MPRIP | SERPINB6 | 0.686136 | 10 | 0 | 10 |
| MPRIP | FOXP1 | 0.684238 | 5 | 0 | 5 |
| MPRIP | C6orf132 | 0.682135 | 5 | 0 | 4 |
| MPRIP | FBXO10 | 0.680854 | 3 | 0 | 3 |
| MPRIP | LPIN1 | 0.680523 | 11 | 0 | 10 |
| MPRIP | ARHGAP10 | 0.679286 | 12 | 0 | 10 |
| MPRIP | VSIG10L | 0.676966 | 6 | 0 | 6 |
| MPRIP | SECISBP2L | 0.675842 | 12 | 0 | 10 |
| MPRIP | KAT2B | 0.674748 | 10 | 0 | 9 |
| MPRIP | KLHDC8B | 0.670733 | 4 | 0 | 4 |
| MPRIP | PTPN3 | 0.670294 | 6 | 0 | 6 |
| MPRIP | B3GNT8 | 0.666405 | 3 | 0 | 3 |
| MPRIP | FGD5-AS1 | 0.66586 | 4 | 0 | 4 |
| MPRIP | RAB10 | 0.661926 | 5 | 0 | 5 |
For details and further investigation, click here
