| Full name: syndecan 4 | Alias Symbol: SYND4|amphiglycan|ryudocan | ||
| Type: protein-coding gene | Cytoband: 20q13.12 | ||
| Entrez ID: 6385 | HGNC ID: HGNC:10661 | Ensembl Gene: ENSG00000124145 | OMIM ID: 600017 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
SDC4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05205 | Proteoglycans in cancer |
Expression of SDC4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SDC4 | 6385 | 202071_at | 0.3612 | 0.6720 | |
| GSE20347 | SDC4 | 6385 | 202071_at | -0.2779 | 0.1551 | |
| GSE23400 | SDC4 | 6385 | 202071_at | -0.0381 | 0.7505 | |
| GSE26886 | SDC4 | 6385 | 202071_at | -0.4751 | 0.2687 | |
| GSE29001 | SDC4 | 6385 | 202071_at | 0.1294 | 0.7744 | |
| GSE38129 | SDC4 | 6385 | 202071_at | -0.1600 | 0.3196 | |
| GSE45670 | SDC4 | 6385 | 202071_at | 0.0110 | 0.9774 | |
| GSE53622 | SDC4 | 6385 | 38026 | -0.1684 | 0.1227 | |
| GSE53624 | SDC4 | 6385 | 38026 | -0.1681 | 0.0403 | |
| GSE63941 | SDC4 | 6385 | 202071_at | -0.5117 | 0.5608 | |
| GSE77861 | SDC4 | 6385 | 202071_at | 0.1900 | 0.5072 | |
| GSE97050 | SDC4 | 6385 | A_23_P109034 | 0.2868 | 0.3038 | |
| SRP007169 | SDC4 | 6385 | RNAseq | -1.1635 | 0.0261 | |
| SRP008496 | SDC4 | 6385 | RNAseq | -0.9592 | 0.0152 | |
| SRP064894 | SDC4 | 6385 | RNAseq | -0.1877 | 0.4431 | |
| SRP133303 | SDC4 | 6385 | RNAseq | 0.7134 | 0.0183 | |
| SRP159526 | SDC4 | 6385 | RNAseq | -0.1554 | 0.7507 | |
| SRP193095 | SDC4 | 6385 | RNAseq | 0.0848 | 0.6917 | |
| SRP219564 | SDC4 | 6385 | RNAseq | -0.0701 | 0.9032 | |
| TCGA | SDC4 | 6385 | RNAseq | -0.0579 | 0.4204 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SDC4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SDC4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SDC4 | 6385 | 14 | 1 | 15 | |
| GSE20123 | SDC4 | 6385 | 14 | 1 | 15 | |
| GSE43470 | SDC4 | 6385 | 12 | 1 | 30 | |
| GSE46452 | SDC4 | 6385 | 29 | 0 | 30 | |
| GSE47630 | SDC4 | 6385 | 24 | 1 | 15 | |
| GSE54993 | SDC4 | 6385 | 0 | 17 | 53 | |
| GSE54994 | SDC4 | 6385 | 25 | 0 | 28 | |
| GSE60625 | SDC4 | 6385 | 0 | 0 | 11 | |
| GSE74703 | SDC4 | 6385 | 10 | 1 | 25 | |
| GSE74704 | SDC4 | 6385 | 10 | 0 | 10 | |
| TCGA | SDC4 | 6385 | 45 | 3 | 48 |
Total number of gains: 183; Total number of losses: 25; Total Number of normals: 280.
Somatic mutations of SDC4:
Generating mutation plots.
Highly correlated genes for SDC4:
Showing top 20/118 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SDC4 | LRRC42 | 0.714166 | 4 | 0 | 4 |
| SDC4 | FAM107B | 0.707005 | 3 | 0 | 3 |
| SDC4 | NUP93 | 0.693247 | 3 | 0 | 3 |
| SDC4 | MRPL28 | 0.68069 | 3 | 0 | 3 |
| SDC4 | EME1 | 0.677238 | 3 | 0 | 3 |
| SDC4 | GCNT1 | 0.673154 | 3 | 0 | 3 |
| SDC4 | AP1AR | 0.671443 | 4 | 0 | 4 |
| SDC4 | SLC7A6OS | 0.662121 | 3 | 0 | 3 |
| SDC4 | SOX9 | 0.656758 | 3 | 0 | 3 |
| SDC4 | CTU2 | 0.654187 | 3 | 0 | 3 |
| SDC4 | TAF1C | 0.646898 | 3 | 0 | 3 |
| SDC4 | PSMB10 | 0.643011 | 3 | 0 | 3 |
| SDC4 | BIRC2 | 0.641484 | 3 | 0 | 3 |
| SDC4 | PSMA7 | 0.637991 | 4 | 0 | 3 |
| SDC4 | INTS9 | 0.631263 | 3 | 0 | 3 |
| SDC4 | HSPA5 | 0.630688 | 3 | 0 | 3 |
| SDC4 | RBM12 | 0.629373 | 3 | 0 | 3 |
| SDC4 | DNTTIP1 | 0.622453 | 4 | 0 | 3 |
| SDC4 | XRCC6 | 0.621798 | 3 | 0 | 3 |
| SDC4 | FARSB | 0.62176 | 3 | 0 | 3 |
For details and further investigation, click here
