DCTPP1

 

Full name: dCTP pyrophosphatase 1 Alias Symbol: MGC5627|RS21C6|CDA03|XTP3TPA
Type: protein-coding gene Cytoband: 16p11.2
Entrez ID: 79077 HGNC ID: HGNC:28777 Ensembl Gene: ENSG00000179958 OMIM ID: 615840
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of DCTPP1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 DCTPP1 79077 218069_at 0.5617 0.4353
GSE20347 DCTPP1 79077 218069_at 0.7462 0.0000
GSE23400 DCTPP1 79077 218069_at 0.5626 0.0000
GSE26886 DCTPP1 79077 218069_at 0.6378 0.0000
GSE29001 DCTPP1 79077 218069_at 0.6788 0.0373
GSE38129 DCTPP1 79077 218069_at 0.8417 0.0000
GSE45670 DCTPP1 79077 218069_at 0.6581 0.0002
GSE53622 DCTPP1 79077 27405 0.7418 0.0000
GSE53624 DCTPP1 79077 27405 1.0238 0.0000
GSE63941 DCTPP1 79077 218069_at 1.7768 0.0008
GSE77861 DCTPP1 79077 218069_at 0.4664 0.0344
GSE97050 DCTPP1 79077 A_23_P33613 0.6362 0.1783
SRP007169 DCTPP1 79077 RNAseq 1.0021 0.0141
SRP008496 DCTPP1 79077 RNAseq 0.7247 0.0025
SRP064894 DCTPP1 79077 RNAseq 0.6269 0.0475
SRP133303 DCTPP1 79077 RNAseq 0.8949 0.0003
SRP159526 DCTPP1 79077 RNAseq 0.9796 0.0021
SRP193095 DCTPP1 79077 RNAseq 0.4438 0.0032
SRP219564 DCTPP1 79077 RNAseq 0.7763 0.1013
TCGA DCTPP1 79077 RNAseq 0.3149 0.0000

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by DCTPP1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of DCTPP1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 DCTPP1 79077 5 5 20
GSE20123 DCTPP1 79077 5 4 21
GSE43470 DCTPP1 79077 3 3 37
GSE46452 DCTPP1 79077 38 1 20
GSE47630 DCTPP1 79077 11 7 22
GSE54993 DCTPP1 79077 2 5 63
GSE54994 DCTPP1 79077 5 9 39
GSE60625 DCTPP1 79077 4 0 7
GSE74703 DCTPP1 79077 3 2 31
GSE74704 DCTPP1 79077 3 2 15
TCGA DCTPP1 79077 20 10 66

Total number of gains: 99; Total number of losses: 48; Total Number of normals: 341.  

 

Somatic mutations of DCTPP1:

 

Generating mutation plots.

 

Highly correlated genes for DCTPP1:

 

Showing top 20/1449 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
DCTPP1CDT10.74943911011
DCTPP1MCM70.74762712012
DCTPP1GINS20.74502313012
DCTPP1PDPR0.741102303
DCTPP1MCM20.7376613012
DCTPP1RAD51AP10.73522611011
DCTPP1SEPHS20.73354710010
DCTPP1RNPS10.733079908
DCTPP1SNRPG0.73215310010
DCTPP1POLR3K0.73095113010
DCTPP1NUDT10.72948112012
DCTPP1RAD510.72944912012
DCTPP1KIF220.72662912011
DCTPP1MCM50.72549611010
DCTPP1PLK10.72376711010
DCTPP1TXNDC120.72286707
DCTPP1RNASEH2A0.72176113012
DCTPP1MAD2L10.72139911010
DCTPP1EMC80.72102311011
DCTPP1RPA30.7203112011

For details and further investigation, click here