| Full name: mitochondrial ribosomal protein L54 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 116541 | HGNC ID: HGNC:16685 | Ensembl Gene: ENSG00000183617 | OMIM ID: 611858 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of MRPL54:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MRPL54 | 116541 | 225797_at | -0.5039 | 0.0446 | |
| GSE26886 | MRPL54 | 116541 | 225797_at | 0.5485 | 0.0011 | |
| GSE45670 | MRPL54 | 116541 | 225797_at | -0.0822 | 0.4741 | |
| GSE53622 | MRPL54 | 116541 | 29639 | -0.5800 | 0.0000 | |
| GSE53624 | MRPL54 | 116541 | 29639 | -0.3765 | 0.0000 | |
| GSE63941 | MRPL54 | 116541 | 225797_at | -0.3258 | 0.4486 | |
| GSE77861 | MRPL54 | 116541 | 225797_at | -0.2197 | 0.1375 | |
| GSE97050 | MRPL54 | 116541 | A_23_P101742 | -0.1405 | 0.5931 | |
| SRP007169 | MRPL54 | 116541 | RNAseq | -0.7310 | 0.0306 | |
| SRP008496 | MRPL54 | 116541 | RNAseq | -0.8777 | 0.0001 | |
| SRP064894 | MRPL54 | 116541 | RNAseq | -0.2813 | 0.4197 | |
| SRP133303 | MRPL54 | 116541 | RNAseq | -0.3256 | 0.0433 | |
| SRP159526 | MRPL54 | 116541 | RNAseq | -0.7470 | 0.0055 | |
| SRP193095 | MRPL54 | 116541 | RNAseq | -0.6766 | 0.0000 | |
| SRP219564 | MRPL54 | 116541 | RNAseq | 0.0346 | 0.9198 | |
| TCGA | MRPL54 | 116541 | RNAseq | -0.1474 | 0.0229 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MRPL54 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MRPL54:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MRPL54 | 116541 | 5 | 3 | 22 | |
| GSE20123 | MRPL54 | 116541 | 4 | 2 | 24 | |
| GSE43470 | MRPL54 | 116541 | 1 | 9 | 33 | |
| GSE46452 | MRPL54 | 116541 | 47 | 1 | 11 | |
| GSE47630 | MRPL54 | 116541 | 5 | 7 | 28 | |
| GSE54993 | MRPL54 | 116541 | 16 | 3 | 51 | |
| GSE54994 | MRPL54 | 116541 | 8 | 16 | 29 | |
| GSE60625 | MRPL54 | 116541 | 9 | 0 | 2 | |
| GSE74703 | MRPL54 | 116541 | 1 | 6 | 29 | |
| GSE74704 | MRPL54 | 116541 | 1 | 2 | 17 | |
| TCGA | MRPL54 | 116541 | 10 | 19 | 67 |
Total number of gains: 107; Total number of losses: 68; Total Number of normals: 313.
Somatic mutations of MRPL54:
Generating mutation plots.
Highly correlated genes for MRPL54:
Showing top 20/80 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MRPL54 | COMTD1 | 0.721224 | 3 | 0 | 3 |
| MRPL54 | WDR60 | 0.65696 | 3 | 0 | 3 |
| MRPL54 | METTL25 | 0.655925 | 5 | 0 | 3 |
| MRPL54 | TRIOBP | 0.654562 | 3 | 0 | 3 |
| MRPL54 | FGF10 | 0.652017 | 4 | 0 | 4 |
| MRPL54 | NDUFB7 | 0.646449 | 7 | 0 | 5 |
| MRPL54 | FAM172A | 0.644631 | 3 | 0 | 3 |
| MRPL54 | RNF167 | 0.637085 | 4 | 0 | 4 |
| MRPL54 | ACKR1 | 0.634194 | 3 | 0 | 3 |
| MRPL54 | RSPO1 | 0.630327 | 4 | 0 | 4 |
| MRPL54 | MSRA | 0.617712 | 4 | 0 | 4 |
| MRPL54 | ADAMTS17 | 0.611473 | 3 | 0 | 3 |
| MRPL54 | LINC01082 | 0.609363 | 3 | 0 | 3 |
| MRPL54 | C19orf33 | 0.608948 | 3 | 0 | 3 |
| MRPL54 | DISP1 | 0.600872 | 3 | 0 | 3 |
| MRPL54 | RPL29 | 0.600804 | 6 | 0 | 6 |
| MRPL54 | NDUFS7 | 0.599541 | 4 | 0 | 4 |
| MRPL54 | TMEM141 | 0.596758 | 4 | 0 | 3 |
| MRPL54 | SF3B5 | 0.595216 | 4 | 0 | 3 |
| MRPL54 | EIF3K | 0.594822 | 5 | 0 | 4 |
For details and further investigation, click here
