MS4A4A

 

Full name: membrane spanning 4-domains A4A Alias Symbol: CD20L1|MS4A7
Type: protein-coding gene Cytoband: 11q12.2
Entrez ID: 51338 HGNC ID: HGNC:13371 Ensembl Gene: ENSG00000110079 OMIM ID: 606547
Drug and gene relationship at DGIdb

 

Expression of MS4A4A:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MS4A4A 51338 219607_s_at -0.3751 0.8713
GSE20347 MS4A4A 51338 219607_s_at 0.5695 0.0192
GSE23400 MS4A4A 51338 219607_s_at 0.5033 0.0009
GSE26886 MS4A4A 51338 224357_s_at 0.2372 0.0764
GSE29001 MS4A4A 51338 219607_s_at 1.7429 0.0048
GSE38129 MS4A4A 51338 219607_s_at 0.5417 0.2950
GSE45670 MS4A4A 51338 224357_s_at -0.4878 0.0039
GSE53622 MS4A4A 51338 37061 -0.1010 0.5840
GSE53624 MS4A4A 51338 37061 0.5127 0.0145
GSE63941 MS4A4A 51338 224357_s_at 0.1199 0.3187
GSE77861 MS4A4A 51338 224357_s_at 0.0033 0.9806
GSE97050 MS4A4A 51338 A_23_P75769 0.3119 0.5613
SRP007169 MS4A4A 51338 RNAseq 2.6059 0.0034
SRP008496 MS4A4A 51338 RNAseq 2.5953 0.0000
SRP064894 MS4A4A 51338 RNAseq 0.8345 0.0728
SRP133303 MS4A4A 51338 RNAseq 0.3737 0.4071
SRP159526 MS4A4A 51338 RNAseq 0.6411 0.3157
SRP193095 MS4A4A 51338 RNAseq 0.8723 0.0105
SRP219564 MS4A4A 51338 RNAseq 1.2620 0.1226
TCGA MS4A4A 51338 RNAseq -0.0088 0.9662

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by MS4A4A expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MS4A4A:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MS4A4A 51338 2 4 24
GSE20123 MS4A4A 51338 2 4 24
GSE43470 MS4A4A 51338 2 5 36
GSE46452 MS4A4A 51338 8 4 47
GSE47630 MS4A4A 51338 3 8 29
GSE54993 MS4A4A 51338 3 0 67
GSE54994 MS4A4A 51338 5 5 43
GSE60625 MS4A4A 51338 0 3 8
GSE74703 MS4A4A 51338 2 3 31
GSE74704 MS4A4A 51338 2 3 15
TCGA MS4A4A 51338 14 10 72

Total number of gains: 43; Total number of losses: 49; Total Number of normals: 396.  

 

Somatic mutations of MS4A4A:

 

Generating mutation plots.

 

Highly correlated genes for MS4A4A:

 

Showing top 20/566 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MS4A4ACD1630.85074511011
MS4A4AMRC10.81793410010
MS4A4AC3AR10.79608310010
MS4A4AC19orf380.795662303
MS4A4ADEXI0.795299303
MS4A4AC1QA0.79016611010
MS4A4ACSF1R0.7753741009
MS4A4AC1QB0.77363911011
MS4A4ATYROBP0.7597711010
MS4A4ACMKLR10.759442605
MS4A4AVSIG40.75792211011
MS4A4ACYBB0.74851511010
MS4A4AMPEG10.744706605
MS4A4AGPR340.742056706
MS4A4APPP1R16B0.740006303
MS4A4ACERKL0.730897303
MS4A4ATRIM470.730564303
MS4A4ACD140.72953711010
MS4A4AC1orf1620.724474706
MS4A4ACCL180.7228231009

For details and further investigation, click here