| Full name: C-C motif chemokine ligand 18 | Alias Symbol: DC-CK1|PARC|AMAC-1|DCCK1|MIP-4|CKb7 | ||
| Type: protein-coding gene | Cytoband: 17q12 | ||
| Entrez ID: 6362 | HGNC ID: HGNC:10616 | Ensembl Gene: ENSG00000275385 | OMIM ID: 603757 |
| Drug and gene relationship at DGIdb | |||
CCL18 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04062 | Chemokine signaling pathway |
Expression of CCL18:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CCL18 | 6362 | 32128_at | 0.5672 | 0.8312 | |
| GSE20347 | CCL18 | 6362 | 209924_at | 0.6252 | 0.0249 | |
| GSE23400 | CCL18 | 6362 | 209924_at | 0.4884 | 0.0011 | |
| GSE26886 | CCL18 | 6362 | 209924_at | 0.4419 | 0.2378 | |
| GSE29001 | CCL18 | 6362 | 209924_at | 0.8005 | 0.0661 | |
| GSE38129 | CCL18 | 6362 | 32128_at | 1.0199 | 0.0225 | |
| GSE45670 | CCL18 | 6362 | 32128_at | 0.9856 | 0.1037 | |
| GSE53622 | CCL18 | 6362 | 105512 | 1.3550 | 0.0001 | |
| GSE53624 | CCL18 | 6362 | 105512 | 1.5546 | 0.0000 | |
| GSE63941 | CCL18 | 6362 | 209924_at | 0.0950 | 0.5650 | |
| GSE77861 | CCL18 | 6362 | 209924_at | 0.2928 | 0.2463 | |
| GSE97050 | CCL18 | 6362 | A_23_P55270 | 1.5575 | 0.1453 | |
| SRP007169 | CCL18 | 6362 | RNAseq | 6.1043 | 0.0000 | |
| SRP008496 | CCL18 | 6362 | RNAseq | 6.0097 | 0.0000 | |
| SRP064894 | CCL18 | 6362 | RNAseq | 2.4375 | 0.0000 | |
| SRP133303 | CCL18 | 6362 | RNAseq | 1.3572 | 0.1247 | |
| SRP159526 | CCL18 | 6362 | RNAseq | 2.9787 | 0.0023 | |
| TCGA | CCL18 | 6362 | RNAseq | 0.6660 | 0.0181 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by CCL18 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CCL18:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CCL18 | 6362 | 5 | 1 | 24 | |
| GSE20123 | CCL18 | 6362 | 5 | 1 | 24 | |
| GSE43470 | CCL18 | 6362 | 1 | 2 | 40 | |
| GSE46452 | CCL18 | 6362 | 34 | 0 | 25 | |
| GSE47630 | CCL18 | 6362 | 7 | 1 | 32 | |
| GSE54993 | CCL18 | 6362 | 3 | 3 | 64 | |
| GSE54994 | CCL18 | 6362 | 8 | 6 | 39 | |
| GSE60625 | CCL18 | 6362 | 4 | 0 | 7 | |
| GSE74703 | CCL18 | 6362 | 1 | 1 | 34 | |
| GSE74704 | CCL18 | 6362 | 3 | 1 | 16 | |
| TCGA | CCL18 | 6362 | 20 | 9 | 67 |
Total number of gains: 91; Total number of losses: 25; Total Number of normals: 372.
Somatic mutations of CCL18:
Generating mutation plots.
Highly correlated genes for CCL18:
Showing top 20/594 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CCL18 | FCGR3A | 0.754992 | 3 | 0 | 3 |
| CCL18 | PIGS | 0.745188 | 3 | 0 | 3 |
| CCL18 | CD163 | 0.737106 | 11 | 0 | 10 |
| CCL18 | P2RY8 | 0.725386 | 3 | 0 | 3 |
| CCL18 | CLEC12A | 0.724707 | 4 | 0 | 4 |
| CCL18 | MPEG1 | 0.723452 | 4 | 0 | 3 |
| CCL18 | MS4A4A | 0.722823 | 10 | 0 | 9 |
| CCL18 | C19orf38 | 0.71715 | 3 | 0 | 3 |
| CCL18 | FCER1G | 0.714443 | 10 | 0 | 9 |
| CCL18 | GNGT2 | 0.712682 | 3 | 0 | 3 |
| CCL18 | MRC1 | 0.712193 | 10 | 0 | 9 |
| CCL18 | C3AR1 | 0.711087 | 10 | 0 | 9 |
| CCL18 | PIK3AP1 | 0.708361 | 6 | 0 | 4 |
| CCL18 | TFEC | 0.705714 | 10 | 0 | 9 |
| CCL18 | LRRC8C | 0.701916 | 3 | 0 | 3 |
| CCL18 | ST8SIA4 | 0.700776 | 5 | 0 | 5 |
| CCL18 | C1orf162 | 0.700123 | 5 | 0 | 5 |
| CCL18 | SLC7A7 | 0.695427 | 11 | 0 | 11 |
| CCL18 | FCGR2A | 0.694981 | 11 | 0 | 10 |
| CCL18 | CYBB | 0.693083 | 10 | 0 | 9 |
For details and further investigation, click here
