EIF3B

 

Full name: eukaryotic translation initiation factor 3 subunit B Alias Symbol: PRT1|eIF3b
Type: protein-coding gene Cytoband: 7p22.3
Entrez ID: 8662 HGNC ID: HGNC:3280 Ensembl Gene: ENSG00000106263 OMIM ID: 603917
Drug and gene relationship at DGIdb

 

Expression of EIF3B:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 EIF3B 8662 208688_x_at 0.6942 0.0106
GSE20347 EIF3B 8662 208688_x_at 0.7549 0.0000
GSE23400 EIF3B 8662 203462_x_at 0.6143 0.0000
GSE26886 EIF3B 8662 208688_x_at 0.5127 0.0038
GSE29001 EIF3B 8662 203462_x_at 0.5145 0.1207
GSE38129 EIF3B 8662 208688_x_at 0.8141 0.0000
GSE45670 EIF3B 8662 208688_x_at 0.6572 0.0000
GSE53622 EIF3B 8662 41981 0.6987 0.0000
GSE53624 EIF3B 8662 104099 0.8806 0.0000
GSE63941 EIF3B 8662 208688_x_at 0.8800 0.0202
GSE77861 EIF3B 8662 203462_x_at 0.7337 0.0003
GSE97050 EIF3B 8662 A_33_P3239222 0.5925 0.2433
SRP007169 EIF3B 8662 RNAseq 0.8360 0.0543
SRP008496 EIF3B 8662 RNAseq 0.8923 0.0042
SRP064894 EIF3B 8662 RNAseq 0.7221 0.0001
SRP133303 EIF3B 8662 RNAseq 0.7672 0.0002
SRP159526 EIF3B 8662 RNAseq 0.5457 0.0055
SRP193095 EIF3B 8662 RNAseq 0.5120 0.0001
SRP219564 EIF3B 8662 RNAseq 0.4275 0.2615
TCGA EIF3B 8662 RNAseq 0.1948 0.0000

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by EIF3B expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of EIF3B:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 EIF3B 8662 14 0 16
GSE20123 EIF3B 8662 14 0 16
GSE43470 EIF3B 8662 7 2 34
GSE46452 EIF3B 8662 13 1 45
GSE47630 EIF3B 8662 10 1 29
GSE54993 EIF3B 8662 0 7 63
GSE54994 EIF3B 8662 20 3 30
GSE60625 EIF3B 8662 0 0 11
GSE74703 EIF3B 8662 7 1 28
GSE74704 EIF3B 8662 9 0 11
TCGA EIF3B 8662 56 5 35

Total number of gains: 150; Total number of losses: 20; Total Number of normals: 318.  

 

Somatic mutations of EIF3B:

 

Generating mutation plots.

 

Highly correlated genes for EIF3B:

 

Showing top 20/1317 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
EIF3BCDCA20.8335303
EIF3BUBE2C0.794741909
EIF3BAURKA0.772848808
EIF3BUHRF10.76886606
EIF3BNUDT10.76803812010
EIF3BTRIP130.766682909
EIF3BSAC3D10.75978410010
EIF3BNSUN20.755014505
EIF3BMRGBP0.746433909
EIF3BFEN10.741819807
EIF3BMTBP0.74157404
EIF3BC19orf480.738781303
EIF3BTTL0.734373606
EIF3BDDX39A0.73267911011
EIF3BHOXC90.732565505
EIF3BEFTUD20.731538707
EIF3BKIF140.731437908
EIF3BE2F70.731163505
EIF3BEIF2AK10.7310112012
EIF3BLMNB20.7290281009

For details and further investigation, click here