| Full name: insulin like growth factor 2 mRNA binding protein 1 | Alias Symbol: IMP-1 | ||
| Type: protein-coding gene | Cytoband: 17q21.32 | ||
| Entrez ID: 10642 | HGNC ID: HGNC:28866 | Ensembl Gene: ENSG00000159217 | OMIM ID: 608288 |
| Drug and gene relationship at DGIdb | |||
Expression of IGF2BP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IGF2BP1 | 10642 | 227377_at | 0.1815 | 0.5601 | |
| GSE26886 | IGF2BP1 | 10642 | 227377_at | 0.4413 | 0.0625 | |
| GSE45670 | IGF2BP1 | 10642 | 223689_at | 0.3586 | 0.0084 | |
| GSE53622 | IGF2BP1 | 10642 | 58862 | 1.7628 | 0.0000 | |
| GSE53624 | IGF2BP1 | 10642 | 58862 | 2.5158 | 0.0000 | |
| GSE63941 | IGF2BP1 | 10642 | 227377_at | 1.5808 | 0.0506 | |
| GSE77861 | IGF2BP1 | 10642 | 227377_at | 0.0930 | 0.4730 | |
| GSE97050 | IGF2BP1 | 10642 | A_23_P83498 | 0.3249 | 0.2569 | |
| SRP159526 | IGF2BP1 | 10642 | RNAseq | 5.4009 | 0.0000 | |
| TCGA | IGF2BP1 | 10642 | RNAseq | 1.8179 | 0.0026 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by IGF2BP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IGF2BP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IGF2BP1 | 10642 | 6 | 2 | 22 | |
| GSE20123 | IGF2BP1 | 10642 | 6 | 2 | 22 | |
| GSE43470 | IGF2BP1 | 10642 | 3 | 2 | 38 | |
| GSE46452 | IGF2BP1 | 10642 | 32 | 0 | 27 | |
| GSE47630 | IGF2BP1 | 10642 | 9 | 0 | 31 | |
| GSE54993 | IGF2BP1 | 10642 | 2 | 4 | 64 | |
| GSE54994 | IGF2BP1 | 10642 | 10 | 6 | 37 | |
| GSE60625 | IGF2BP1 | 10642 | 4 | 0 | 7 | |
| GSE74703 | IGF2BP1 | 10642 | 3 | 2 | 31 | |
| GSE74704 | IGF2BP1 | 10642 | 4 | 1 | 15 | |
| TCGA | IGF2BP1 | 10642 | 26 | 7 | 63 |
Total number of gains: 105; Total number of losses: 26; Total Number of normals: 357.
Somatic mutations of IGF2BP1:
Generating mutation plots.
Highly correlated genes for IGF2BP1:
Showing top 20/163 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IGF2BP1 | CSNK1E | 0.636233 | 3 | 0 | 3 |
| IGF2BP1 | MSLN | 0.631668 | 3 | 0 | 3 |
| IGF2BP1 | TNIP3 | 0.627255 | 3 | 0 | 3 |
| IGF2BP1 | CLCN2 | 0.625806 | 5 | 0 | 5 |
| IGF2BP1 | TRMT112 | 0.623 | 3 | 0 | 3 |
| IGF2BP1 | YES1 | 0.619203 | 3 | 0 | 3 |
| IGF2BP1 | TNFRSF12A | 0.598067 | 4 | 0 | 3 |
| IGF2BP1 | CHD4 | 0.597546 | 3 | 0 | 3 |
| IGF2BP1 | HHLA3 | 0.593954 | 3 | 0 | 3 |
| IGF2BP1 | PPFIA1 | 0.591941 | 5 | 0 | 3 |
| IGF2BP1 | CENPO | 0.591029 | 5 | 0 | 4 |
| IGF2BP1 | IL27RA | 0.588689 | 3 | 0 | 3 |
| IGF2BP1 | TREML1 | 0.583067 | 3 | 0 | 3 |
| IGF2BP1 | SLCO1B3 | 0.581711 | 4 | 0 | 3 |
| IGF2BP1 | BCL7A | 0.573519 | 5 | 0 | 3 |
| IGF2BP1 | CCDC134 | 0.572084 | 3 | 0 | 3 |
| IGF2BP1 | MFAP2 | 0.571498 | 4 | 0 | 3 |
| IGF2BP1 | KIF2C | 0.571141 | 6 | 0 | 5 |
| IGF2BP1 | DLX4 | 0.571138 | 8 | 0 | 5 |
| IGF2BP1 | CCDC138 | 0.570254 | 4 | 0 | 3 |
For details and further investigation, click here
