VRK1

 

Full name: VRK serine/threonine kinase 1 Alias Symbol: 
Type: protein-coding gene Cytoband: 14q32.2
Entrez ID: 7443 HGNC ID: HGNC:12718 Ensembl Gene: ENSG00000100749 OMIM ID: 602168
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of VRK1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 VRK1 7443 203856_at 0.9028 0.0331
GSE20347 VRK1 7443 203856_at 1.4091 0.0000
GSE23400 VRK1 7443 203856_at 1.3061 0.0000
GSE26886 VRK1 7443 203856_at 0.8168 0.0055
GSE29001 VRK1 7443 203856_at 1.2774 0.0074
GSE38129 VRK1 7443 203856_at 1.2663 0.0000
GSE45670 VRK1 7443 203856_at 0.9507 0.0001
GSE53622 VRK1 7443 88138 0.7472 0.0000
GSE53624 VRK1 7443 88138 1.0737 0.0000
GSE63941 VRK1 7443 203856_at 2.2462 0.0004
GSE77861 VRK1 7443 203856_at 0.8462 0.1134
GSE97050 VRK1 7443 A_23_P76761 0.6902 0.2151
SRP007169 VRK1 7443 RNAseq 0.6247 0.1332
SRP008496 VRK1 7443 RNAseq 0.6024 0.0182
SRP064894 VRK1 7443 RNAseq 0.7424 0.0010
SRP133303 VRK1 7443 RNAseq 1.0998 0.0000
SRP159526 VRK1 7443 RNAseq 0.8172 0.0599
SRP193095 VRK1 7443 RNAseq 0.5682 0.0005
SRP219564 VRK1 7443 RNAseq 0.7305 0.0761
TCGA VRK1 7443 RNAseq 0.2738 0.0006

Upregulated datasets: 7; Downregulated datasets: 0.  

 

Survival by VRK1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of VRK1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 VRK1 7443 10 4 16
GSE20123 VRK1 7443 10 3 17
GSE43470 VRK1 7443 9 3 31
GSE46452 VRK1 7443 17 3 39
GSE47630 VRK1 7443 11 8 21
GSE54993 VRK1 7443 3 8 59
GSE54994 VRK1 7443 21 4 28
GSE60625 VRK1 7443 0 2 9
GSE74703 VRK1 7443 7 3 26
GSE74704 VRK1 7443 6 3 11
TCGA VRK1 7443 30 19 47

Total number of gains: 124; Total number of losses: 60; Total Number of normals: 304.  

 

Somatic mutations of VRK1:

 

Generating mutation plots.

 

Highly correlated genes for VRK1:

 

Showing top 20/1785 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
VRK1CDKN30.82892313013
VRK1EME10.806282505
VRK1TTK0.80507112012
VRK1WDHD10.7911513013
VRK1DLGAP50.78677412012
VRK1CDC200.78047211011
VRK1RACGAP10.78023611011
VRK1SLC36A40.770907303
VRK1GINS10.7706412012
VRK1GMNN0.76568213013
VRK1POLE20.75973412012
VRK1CBX30.75877110010
VRK1PLEKHH10.755754303
VRK1GLRX50.75254613013
VRK1BUB10.75155611011
VRK1HPRT10.75118713013
VRK1CKS1B0.74621912011
VRK1MTERF30.745971808
VRK1ERH0.74595912011
VRK1ATAD20.74591913013

For details and further investigation, click here