| Full name: myosin heavy chain 2 | Alias Symbol: MYH2A|MYHSA2|MyHC-IIa|MYHas8|MyHC-2A | ||
| Type: protein-coding gene | Cytoband: 17p13.1 | ||
| Entrez ID: 4620 | HGNC ID: HGNC:7572 | Ensembl Gene: ENSG00000125414 | OMIM ID: 160740 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
MYH2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04530 | Tight junction |
Expression of MYH2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MYH2 | 4620 | 204631_at | 0.1465 | 0.6174 | |
| GSE20347 | MYH2 | 4620 | 204631_at | -0.0730 | 0.1780 | |
| GSE23400 | MYH2 | 4620 | 204631_at | -0.0531 | 0.1278 | |
| GSE26886 | MYH2 | 4620 | 204631_at | 0.0297 | 0.7802 | |
| GSE29001 | MYH2 | 4620 | 204631_at | 0.0032 | 0.9809 | |
| GSE38129 | MYH2 | 4620 | 204631_at | -0.2086 | 0.0021 | |
| GSE45670 | MYH2 | 4620 | 204631_at | -0.0033 | 0.9724 | |
| GSE53622 | MYH2 | 4620 | 2628 | 0.0188 | 0.9443 | |
| GSE53624 | MYH2 | 4620 | 2628 | 0.5635 | 0.0000 | |
| GSE63941 | MYH2 | 4620 | 204631_at | -0.1493 | 0.2046 | |
| GSE77861 | MYH2 | 4620 | 204631_at | -0.1114 | 0.2131 | |
| GSE97050 | MYH2 | 4620 | A_23_P38271 | -1.2034 | 0.2592 | |
| TCGA | MYH2 | 4620 | RNAseq | -4.3009 | 0.0171 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by MYH2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MYH2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MYH2 | 4620 | 2 | 4 | 24 | |
| GSE20123 | MYH2 | 4620 | 2 | 5 | 23 | |
| GSE43470 | MYH2 | 4620 | 2 | 5 | 36 | |
| GSE46452 | MYH2 | 4620 | 34 | 1 | 24 | |
| GSE47630 | MYH2 | 4620 | 7 | 1 | 32 | |
| GSE54993 | MYH2 | 4620 | 4 | 3 | 63 | |
| GSE54994 | MYH2 | 4620 | 5 | 7 | 41 | |
| GSE60625 | MYH2 | 4620 | 4 | 0 | 7 | |
| GSE74703 | MYH2 | 4620 | 2 | 3 | 31 | |
| GSE74704 | MYH2 | 4620 | 1 | 2 | 17 | |
| TCGA | MYH2 | 4620 | 18 | 20 | 58 |
Total number of gains: 81; Total number of losses: 51; Total Number of normals: 356.
Somatic mutations of MYH2:
Generating mutation plots.
Highly correlated genes for MYH2:
Showing top 20/132 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MYH2 | OR9Q2 | 0.650098 | 3 | 0 | 3 |
| MYH2 | TRDN | 0.627565 | 4 | 0 | 3 |
| MYH2 | MUC7 | 0.62433 | 3 | 0 | 3 |
| MYH2 | ACTN2 | 0.623571 | 5 | 0 | 4 |
| MYH2 | LYPD8 | 0.622451 | 3 | 0 | 3 |
| MYH2 | TNNC1 | 0.613674 | 4 | 0 | 3 |
| MYH2 | ARRB1 | 0.613365 | 4 | 0 | 3 |
| MYH2 | PDK4 | 0.605123 | 4 | 0 | 3 |
| MYH2 | PEX5L | 0.603791 | 4 | 0 | 3 |
| MYH2 | NEU2 | 0.596622 | 3 | 0 | 3 |
| MYH2 | SPINK4 | 0.595343 | 5 | 0 | 4 |
| MYH2 | IFNA14 | 0.594083 | 6 | 0 | 4 |
| MYH2 | RHAG | 0.593074 | 3 | 0 | 3 |
| MYH2 | ATG10 | 0.591183 | 3 | 0 | 3 |
| MYH2 | AFP | 0.587898 | 4 | 0 | 3 |
| MYH2 | MS4A5 | 0.58688 | 4 | 0 | 3 |
| MYH2 | TAS2R16 | 0.58565 | 5 | 0 | 3 |
| MYH2 | GUCY1A2 | 0.584505 | 3 | 0 | 3 |
| MYH2 | SNAP91 | 0.584194 | 6 | 0 | 6 |
| MYH2 | AVPR2 | 0.582382 | 5 | 0 | 4 |
For details and further investigation, click here
