GUCY1A2

 

Full name: guanylate cyclase 1 soluble subunit alpha 2 Alias Symbol: GC-SA2
Type: protein-coding gene Cytoband: 11q22.3
Entrez ID: 2977 HGNC ID: HGNC:4684 Ensembl Gene: ENSG00000152402 OMIM ID: 601244
Drug and gene relationship at DGIdb

 

GUCY1A2 involved pathways:

KEGG pathway Description View
hsa04022cGMP-PKG signaling pathway
hsa04270Vascular smooth muscle contraction
hsa04540Gap junction
hsa04611Platelet activation
hsa04713Circadian entrainment
hsa04730Long-term depression
hsa04921Oxytocin signaling pathway
hsa04924Renin secretion
hsa04970Salivary secretion

 

Expression of GUCY1A2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GUCY1A2 2977 228731_at 0.4668 0.5665
GSE20347 GUCY1A2 2977 206927_s_at 0.0918 0.3079
GSE23400 GUCY1A2 2977 206927_s_at -0.0567 0.1504
GSE26886 GUCY1A2 2977 230665_at 0.0955 0.5530
GSE29001 GUCY1A2 2977 206927_s_at 0.0981 0.4855
GSE38129 GUCY1A2 2977 206927_s_at 0.0452 0.5913
GSE45670 GUCY1A2 2977 236335_at -0.2744 0.5402
GSE53622 GUCY1A2 2977 76555 1.1122 0.0000
GSE53624 GUCY1A2 2977 15859 0.9771 0.0000
GSE63941 GUCY1A2 2977 206927_s_at -0.0381 0.8490
GSE77861 GUCY1A2 2977 230665_at -0.1295 0.2691
GSE97050 GUCY1A2 2977 A_23_P350001 0.5182 0.3963
SRP007169 GUCY1A2 2977 RNAseq 2.8520 0.0000
SRP008496 GUCY1A2 2977 RNAseq 3.0223 0.0000
SRP064894 GUCY1A2 2977 RNAseq 1.7749 0.0000
SRP133303 GUCY1A2 2977 RNAseq 1.4008 0.0000
SRP159526 GUCY1A2 2977 RNAseq 0.9198 0.0021
SRP193095 GUCY1A2 2977 RNAseq 1.8321 0.0000
SRP219564 GUCY1A2 2977 RNAseq 1.0698 0.1166
TCGA GUCY1A2 2977 RNAseq 0.5768 0.0340

Upregulated datasets: 6; Downregulated datasets: 0.  

 

Survival by GUCY1A2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GUCY1A2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GUCY1A2 2977 0 13 17
GSE20123 GUCY1A2 2977 0 13 17
GSE43470 GUCY1A2 2977 2 6 35
GSE46452 GUCY1A2 2977 3 26 30
GSE47630 GUCY1A2 2977 2 19 19
GSE54993 GUCY1A2 2977 10 0 60
GSE54994 GUCY1A2 2977 4 19 30
GSE60625 GUCY1A2 2977 0 3 8
GSE74703 GUCY1A2 2977 1 4 31
GSE74704 GUCY1A2 2977 0 9 11
TCGA GUCY1A2 2977 8 46 42

Total number of gains: 30; Total number of losses: 158; Total Number of normals: 300.  

 

Somatic mutations of GUCY1A2:

 

Generating mutation plots.

 

Highly correlated genes for GUCY1A2:

 

Showing top 20/553 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GUCY1A2PROCR0.736658404
GUCY1A2MTNR1A0.717213303
GUCY1A2LRRC8C0.713026303
GUCY1A2AKAP50.711317303
GUCY1A2FKBP100.710813505
GUCY1A2ZNF804A0.707736303
GUCY1A2TLR10.705306303
GUCY1A2ITGAM0.705197303
GUCY1A2TANC20.704657404
GUCY1A2APBB20.692747303
GUCY1A2TNFAIP60.691943606
GUCY1A2THSD10.690153303
GUCY1A2ANGPT20.686166504
GUCY1A2TNS30.684392505
GUCY1A2FLRT20.684002303
GUCY1A2OLR10.683265303
GUCY1A2CNIH30.681728303
GUCY1A2RASGRP30.67639303
GUCY1A2PDE120.671326303
GUCY1A2CHN10.670963705

For details and further investigation, click here