| Full name: myosin light chain, phosphorylatable, fast skeletal muscle | Alias Symbol: MRLC2|HUMMLC2B|MYL11 | ||
| Type: protein-coding gene | Cytoband: 16p11.2 | ||
| Entrez ID: 29895 | HGNC ID: HGNC:29824 | Ensembl Gene: ENSG00000180209 | OMIM ID: 617378 |
| Drug and gene relationship at DGIdb | |||
MYLPF involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04510 | Focal adhesion | |
| hsa04530 | Tight junction | |
| hsa04670 | Leukocyte transendothelial migration | |
| hsa04810 | Regulation of actin cytoskeleton |
Expression of MYLPF:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MYLPF | 29895 | 205163_at | -0.0081 | 0.9776 | |
| GSE20347 | MYLPF | 29895 | 205163_at | -0.1646 | 0.0195 | |
| GSE23400 | MYLPF | 29895 | 205163_at | -0.0477 | 0.2404 | |
| GSE26886 | MYLPF | 29895 | 205163_at | 0.0975 | 0.5055 | |
| GSE29001 | MYLPF | 29895 | 205163_at | -0.1774 | 0.1481 | |
| GSE38129 | MYLPF | 29895 | 205163_at | -0.2116 | 0.0077 | |
| GSE45670 | MYLPF | 29895 | 205163_at | -0.0786 | 0.3179 | |
| GSE53622 | MYLPF | 29895 | 11517 | 0.1715 | 0.0446 | |
| GSE53624 | MYLPF | 29895 | 11517 | -0.2654 | 0.0194 | |
| GSE63941 | MYLPF | 29895 | 205163_at | 0.2781 | 0.1305 | |
| GSE77861 | MYLPF | 29895 | 205163_at | -0.1359 | 0.1727 | |
| GSE97050 | MYLPF | 29895 | A_23_P60742 | -0.4284 | 0.2089 | |
| TCGA | MYLPF | 29895 | RNAseq | 1.1129 | 0.1549 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MYLPF expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MYLPF:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MYLPF | 29895 | 5 | 5 | 20 | |
| GSE20123 | MYLPF | 29895 | 5 | 4 | 21 | |
| GSE43470 | MYLPF | 29895 | 3 | 3 | 37 | |
| GSE46452 | MYLPF | 29895 | 38 | 1 | 20 | |
| GSE47630 | MYLPF | 29895 | 11 | 7 | 22 | |
| GSE54993 | MYLPF | 29895 | 2 | 5 | 63 | |
| GSE54994 | MYLPF | 29895 | 5 | 9 | 39 | |
| GSE60625 | MYLPF | 29895 | 4 | 0 | 7 | |
| GSE74703 | MYLPF | 29895 | 3 | 2 | 31 | |
| GSE74704 | MYLPF | 29895 | 3 | 2 | 15 | |
| TCGA | MYLPF | 29895 | 20 | 10 | 66 |
Total number of gains: 99; Total number of losses: 48; Total Number of normals: 341.
Somatic mutations of MYLPF:
Generating mutation plots.
Highly correlated genes for MYLPF:
Showing top 20/361 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MYLPF | HOXD9 | 0.720063 | 3 | 0 | 3 |
| MYLPF | GAB2 | 0.715817 | 3 | 0 | 3 |
| MYLPF | STAC2 | 0.681638 | 3 | 0 | 3 |
| MYLPF | NPPB | 0.681086 | 4 | 0 | 4 |
| MYLPF | ST8SIA3 | 0.676122 | 3 | 0 | 3 |
| MYLPF | EFNA2 | 0.673285 | 6 | 0 | 5 |
| MYLPF | SLC25A18 | 0.661038 | 4 | 0 | 4 |
| MYLPF | SEMA5A | 0.656381 | 3 | 0 | 3 |
| MYLPF | GAS2L2 | 0.647908 | 3 | 0 | 3 |
| MYLPF | CACNG8 | 0.647203 | 4 | 0 | 3 |
| MYLPF | PAX8 | 0.642727 | 5 | 0 | 4 |
| MYLPF | SLC24A4 | 0.641037 | 4 | 0 | 3 |
| MYLPF | RXFP3 | 0.639993 | 6 | 0 | 6 |
| MYLPF | CHRD | 0.636846 | 4 | 0 | 4 |
| MYLPF | TRPM8 | 0.635773 | 6 | 0 | 5 |
| MYLPF | ZNF264 | 0.634745 | 4 | 0 | 3 |
| MYLPF | MYOD1 | 0.634607 | 4 | 0 | 3 |
| MYLPF | SCLY | 0.634042 | 4 | 0 | 3 |
| MYLPF | LELP1 | 0.63152 | 4 | 0 | 3 |
| MYLPF | SLC22A1 | 0.63089 | 3 | 0 | 3 |
For details and further investigation, click here
