| Full name: solute carrier family 22 member 1 | Alias Symbol: OCT1 | ||
| Type: protein-coding gene | Cytoband: 6q25.3 | ||
| Entrez ID: 6580 | HGNC ID: HGNC:10963 | Ensembl Gene: ENSG00000175003 | OMIM ID: 602607 |
| Drug and gene relationship at DGIdb | |||
SLC22A1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05231 | Choline metabolism in cancer |
Expression of SLC22A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLC22A1 | 6580 | 207201_s_at | 0.1527 | 0.6429 | |
| GSE20347 | SLC22A1 | 6580 | 207201_s_at | -0.0694 | 0.4862 | |
| GSE23400 | SLC22A1 | 6580 | 207201_s_at | -0.0200 | 0.5373 | |
| GSE26886 | SLC22A1 | 6580 | 207201_s_at | 0.3610 | 0.0049 | |
| GSE29001 | SLC22A1 | 6580 | 207201_s_at | 0.0412 | 0.8633 | |
| GSE38129 | SLC22A1 | 6580 | 207201_s_at | 0.0143 | 0.8880 | |
| GSE45670 | SLC22A1 | 6580 | 207201_s_at | 0.5330 | 0.1628 | |
| GSE53622 | SLC22A1 | 6580 | 45612 | 0.7200 | 0.0000 | |
| GSE53624 | SLC22A1 | 6580 | 45612 | 0.8778 | 0.0000 | |
| GSE63941 | SLC22A1 | 6580 | 207201_s_at | -0.0327 | 0.9045 | |
| GSE77861 | SLC22A1 | 6580 | 207201_s_at | -0.0020 | 0.9909 | |
| GSE97050 | SLC22A1 | 6580 | A_23_P145569 | 0.1216 | 0.5613 | |
| SRP133303 | SLC22A1 | 6580 | RNAseq | -0.2286 | 0.3892 | |
| SRP159526 | SLC22A1 | 6580 | RNAseq | 0.8053 | 0.1438 | |
| TCGA | SLC22A1 | 6580 | RNAseq | 1.7893 | 0.0007 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SLC22A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLC22A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLC22A1 | 6580 | 1 | 5 | 24 | |
| GSE20123 | SLC22A1 | 6580 | 1 | 4 | 25 | |
| GSE43470 | SLC22A1 | 6580 | 4 | 0 | 39 | |
| GSE46452 | SLC22A1 | 6580 | 3 | 10 | 46 | |
| GSE47630 | SLC22A1 | 6580 | 9 | 4 | 27 | |
| GSE54993 | SLC22A1 | 6580 | 4 | 4 | 62 | |
| GSE54994 | SLC22A1 | 6580 | 8 | 9 | 36 | |
| GSE60625 | SLC22A1 | 6580 | 0 | 1 | 10 | |
| GSE74703 | SLC22A1 | 6580 | 4 | 0 | 32 | |
| GSE74704 | SLC22A1 | 6580 | 0 | 2 | 18 | |
| TCGA | SLC22A1 | 6580 | 13 | 22 | 61 |
Total number of gains: 47; Total number of losses: 61; Total Number of normals: 380.
Somatic mutations of SLC22A1:
Generating mutation plots.
Highly correlated genes for SLC22A1:
Showing top 20/175 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLC22A1 | DLK1 | 0.772839 | 3 | 0 | 3 |
| SLC22A1 | MGAT5B | 0.73977 | 3 | 0 | 3 |
| SLC22A1 | C20orf141 | 0.708785 | 4 | 0 | 4 |
| SLC22A1 | TNNC2 | 0.705648 | 3 | 0 | 3 |
| SLC22A1 | PHGR1 | 0.691672 | 3 | 0 | 3 |
| SLC22A1 | ASPDH | 0.691588 | 3 | 0 | 3 |
| SLC22A1 | DUSP9 | 0.683802 | 3 | 0 | 3 |
| SLC22A1 | SP8 | 0.682032 | 4 | 0 | 4 |
| SLC22A1 | HOXD9 | 0.654068 | 3 | 0 | 3 |
| SLC22A1 | FBLN7 | 0.649869 | 3 | 0 | 3 |
| SLC22A1 | ZNF524 | 0.644079 | 4 | 0 | 3 |
| SLC22A1 | RIMS4 | 0.642741 | 4 | 0 | 3 |
| SLC22A1 | SP6 | 0.641713 | 3 | 0 | 3 |
| SLC22A1 | PNPLA5 | 0.641706 | 3 | 0 | 3 |
| SLC22A1 | MMP17 | 0.638657 | 5 | 0 | 5 |
| SLC22A1 | MYLPF | 0.63089 | 3 | 0 | 3 |
| SLC22A1 | CHST8 | 0.630288 | 3 | 0 | 3 |
| SLC22A1 | HK3 | 0.627735 | 3 | 0 | 3 |
| SLC22A1 | FOXA3 | 0.620547 | 3 | 0 | 3 |
| SLC22A1 | SH3BP1 | 0.619331 | 4 | 0 | 3 |
For details and further investigation, click here
