| Full name: NLR family apoptosis inhibitory protein | Alias Symbol: NLRB1 | ||
| Type: protein-coding gene | Cytoband: 5q13.2 | ||
| Entrez ID: 4671 | HGNC ID: HGNC:7634 | Ensembl Gene: ENSG00000249437 | OMIM ID: 600355 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
NAIP involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05134 | Legionellosis |
Expression of NAIP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NAIP | 4671 | 238446_at | 0.0473 | 0.9437 | |
| GSE20347 | NAIP | 4671 | 204861_s_at | -0.1584 | 0.3289 | |
| GSE23400 | NAIP | 4671 | 204861_s_at | 0.0304 | 0.6823 | |
| GSE26886 | NAIP | 4671 | 204861_s_at | 0.4048 | 0.0431 | |
| GSE29001 | NAIP | 4671 | 204861_s_at | 0.1204 | 0.6532 | |
| GSE38129 | NAIP | 4671 | 204861_s_at | -0.0393 | 0.8310 | |
| GSE45670 | NAIP | 4671 | 204861_s_at | -0.4065 | 0.1310 | |
| GSE53622 | NAIP | 4671 | 37476 | 0.0426 | 0.7230 | |
| GSE53624 | NAIP | 4671 | 37476 | 0.1442 | 0.1305 | |
| GSE63941 | NAIP | 4671 | 204861_s_at | 0.5470 | 0.2654 | |
| GSE77861 | NAIP | 4671 | 204861_s_at | -0.0431 | 0.8069 | |
| GSE97050 | NAIP | A_21_P0013998 | 0.3410 | 0.3370 | ||
| SRP007169 | NAIP | 4671 | RNAseq | 0.7283 | 0.0963 | |
| SRP008496 | NAIP | 4671 | RNAseq | 0.8773 | 0.0030 | |
| SRP064894 | NAIP | 4671 | RNAseq | 0.0817 | 0.7630 | |
| SRP133303 | NAIP | 4671 | RNAseq | -0.1082 | 0.5951 | |
| SRP159526 | NAIP | 4671 | RNAseq | -0.6116 | 0.2268 | |
| SRP193095 | NAIP | 4671 | RNAseq | 0.0789 | 0.6145 | |
| SRP219564 | NAIP | 4671 | RNAseq | 0.2448 | 0.2773 | |
| TCGA | NAIP | 4671 | RNAseq | -0.1977 | 0.2084 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NAIP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NAIP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NAIP | 4671 | 1 | 13 | 16 | |
| GSE20123 | NAIP | 4671 | 1 | 13 | 16 | |
| GSE43470 | NAIP | 4671 | 1 | 13 | 29 | |
| GSE46452 | NAIP | 4671 | 0 | 28 | 31 | |
| GSE47630 | NAIP | 4671 | 1 | 19 | 20 | |
| GSE54993 | NAIP | 4671 | 8 | 1 | 61 | |
| GSE54994 | NAIP | 4671 | 1 | 20 | 32 | |
| GSE60625 | NAIP | 4671 | 0 | 0 | 11 | |
| GSE74703 | NAIP | 4671 | 1 | 9 | 26 | |
| GSE74704 | NAIP | 4671 | 1 | 6 | 13 | |
| TCGA | NAIP | 4671 | 4 | 51 | 41 |
Total number of gains: 19; Total number of losses: 173; Total Number of normals: 296.
Somatic mutations of NAIP:
Generating mutation plots.
Highly correlated genes for NAIP:
Showing top 20/148 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NAIP | LAIR1 | 0.784063 | 3 | 0 | 3 |
| NAIP | EIF2A | 0.765981 | 3 | 0 | 3 |
| NAIP | TNFSF8 | 0.737705 | 3 | 0 | 3 |
| NAIP | THOC2 | 0.722201 | 3 | 0 | 3 |
| NAIP | LARP1 | 0.719265 | 3 | 0 | 3 |
| NAIP | EIF3M | 0.712805 | 3 | 0 | 3 |
| NAIP | CWC22 | 0.703408 | 3 | 0 | 3 |
| NAIP | DIP2A | 0.694819 | 3 | 0 | 3 |
| NAIP | C1QB | 0.690603 | 3 | 0 | 3 |
| NAIP | GALNT6 | 0.689117 | 3 | 0 | 3 |
| NAIP | CNKSR1 | 0.687344 | 3 | 0 | 3 |
| NAIP | STAB1 | 0.685994 | 4 | 0 | 4 |
| NAIP | SLC35E1 | 0.683999 | 3 | 0 | 3 |
| NAIP | MNT | 0.682834 | 3 | 0 | 3 |
| NAIP | ARHGAP9 | 0.679131 | 3 | 0 | 3 |
| NAIP | CYTH4 | 0.678196 | 4 | 0 | 3 |
| NAIP | IGSF6 | 0.675886 | 3 | 0 | 3 |
| NAIP | DEPDC7 | 0.67558 | 3 | 0 | 3 |
| NAIP | PARVG | 0.674742 | 4 | 0 | 3 |
| NAIP | ZNF513 | 0.673141 | 3 | 0 | 3 |
For details and further investigation, click here
