| Full name: nucleolin | Alias Symbol: C23|Nsr1 | ||
| Type: protein-coding gene | Cytoband: 2q37.1 | ||
| Entrez ID: 4691 | HGNC ID: HGNC:7667 | Ensembl Gene: ENSG00000115053 | OMIM ID: 164035 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of NCL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NCL | 4691 | 200610_s_at | 0.2686 | 0.6376 | |
| GSE20347 | NCL | 4691 | 200610_s_at | 0.3412 | 0.0114 | |
| GSE23400 | NCL | 4691 | 200610_s_at | 0.5465 | 0.0000 | |
| GSE26886 | NCL | 4691 | 200610_s_at | 0.2140 | 0.1409 | |
| GSE29001 | NCL | 4691 | 200610_s_at | 0.5775 | 0.0357 | |
| GSE38129 | NCL | 4691 | 200610_s_at | 0.4202 | 0.0000 | |
| GSE45670 | NCL | 4691 | 200610_s_at | 0.2592 | 0.0227 | |
| GSE53622 | NCL | 4691 | 72877 | 0.4572 | 0.0000 | |
| GSE53624 | NCL | 4691 | 72877 | 0.6449 | 0.0000 | |
| GSE63941 | NCL | 4691 | 200610_s_at | 0.2750 | 0.3339 | |
| GSE77861 | NCL | 4691 | 200610_s_at | 0.5214 | 0.0030 | |
| GSE97050 | NCL | 4691 | A_23_P5551 | 0.5365 | 0.1293 | |
| SRP007169 | NCL | 4691 | RNAseq | 2.7514 | 0.0000 | |
| SRP008496 | NCL | 4691 | RNAseq | 2.5780 | 0.0000 | |
| SRP064894 | NCL | 4691 | RNAseq | 0.1925 | 0.2695 | |
| SRP133303 | NCL | 4691 | RNAseq | 0.4559 | 0.0008 | |
| SRP159526 | NCL | 4691 | RNAseq | 0.4190 | 0.0251 | |
| SRP193095 | NCL | 4691 | RNAseq | 0.1903 | 0.2571 | |
| SRP219564 | NCL | 4691 | RNAseq | 0.3353 | 0.1545 | |
| TCGA | NCL | 4691 | RNAseq | 0.1439 | 0.0003 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by NCL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NCL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NCL | 4691 | 1 | 13 | 16 | |
| GSE20123 | NCL | 4691 | 1 | 12 | 17 | |
| GSE43470 | NCL | 4691 | 1 | 8 | 34 | |
| GSE46452 | NCL | 4691 | 0 | 5 | 54 | |
| GSE47630 | NCL | 4691 | 4 | 5 | 31 | |
| GSE54993 | NCL | 4691 | 2 | 2 | 66 | |
| GSE54994 | NCL | 4691 | 6 | 10 | 37 | |
| GSE60625 | NCL | 4691 | 0 | 3 | 8 | |
| GSE74703 | NCL | 4691 | 1 | 6 | 29 | |
| GSE74704 | NCL | 4691 | 1 | 5 | 14 | |
| TCGA | NCL | 4691 | 12 | 27 | 57 |
Total number of gains: 29; Total number of losses: 96; Total Number of normals: 363.
Somatic mutations of NCL:
Generating mutation plots.
Highly correlated genes for NCL:
Showing top 20/1638 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NCL | SMARCE1 | 0.802061 | 3 | 0 | 3 |
| NCL | MMS22L | 0.738742 | 3 | 0 | 3 |
| NCL | DYRK2 | 0.734514 | 3 | 0 | 3 |
| NCL | VMA21 | 0.729279 | 4 | 0 | 3 |
| NCL | ISY1 | 0.722316 | 4 | 0 | 3 |
| NCL | ORAI1 | 0.722278 | 3 | 0 | 3 |
| NCL | DKC1 | 0.721848 | 3 | 0 | 3 |
| NCL | ZNF707 | 0.721336 | 3 | 0 | 3 |
| NCL | EBNA1BP2 | 0.71769 | 3 | 0 | 3 |
| NCL | ZC3H18 | 0.713081 | 3 | 0 | 3 |
| NCL | NEK9 | 0.708768 | 3 | 0 | 3 |
| NCL | TMEM138 | 0.706351 | 5 | 0 | 5 |
| NCL | HSPD1 | 0.704638 | 12 | 0 | 11 |
| NCL | FUS | 0.704003 | 12 | 0 | 11 |
| NCL | ANAPC1 | 0.702279 | 3 | 0 | 3 |
| NCL | SUPT16H | 0.701484 | 10 | 0 | 9 |
| NCL | MED26 | 0.701416 | 3 | 0 | 3 |
| NCL | FAM89A | 0.69701 | 3 | 0 | 3 |
| NCL | SFPQ | 0.696876 | 10 | 0 | 10 |
| NCL | UBE2C | 0.696213 | 10 | 0 | 10 |
For details and further investigation, click here
