| Full name: protein disulfide isomerase family A member 3 | Alias Symbol: P58|ERp61|ERp57|ERp60|GRP57|PI-PLC|HsT17083 | ||
| Type: protein-coding gene | Cytoband: 15q15.3 | ||
| Entrez ID: 2923 | HGNC ID: HGNC:4606 | Ensembl Gene: ENSG00000167004 | OMIM ID: 602046 |
| Drug and gene relationship at DGIdb | |||
Expression of PDIA3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PDIA3 | 2923 | 208612_at | 0.3802 | 0.2301 | |
| GSE20347 | PDIA3 | 2923 | 208612_at | -0.1305 | 0.4716 | |
| GSE23400 | PDIA3 | 2923 | 208612_at | 0.3789 | 0.0000 | |
| GSE26886 | PDIA3 | 2923 | 208612_at | -0.0330 | 0.8760 | |
| GSE29001 | PDIA3 | 2923 | 208612_at | 0.1391 | 0.7757 | |
| GSE38129 | PDIA3 | 2923 | 208612_at | 0.2955 | 0.1099 | |
| GSE45670 | PDIA3 | 2923 | 208612_at | 0.3620 | 0.0032 | |
| GSE53622 | PDIA3 | 2923 | 77753 | 0.1616 | 0.0332 | |
| GSE53624 | PDIA3 | 2923 | 77753 | 0.0280 | 0.7457 | |
| GSE63941 | PDIA3 | 2923 | 208612_at | 1.0341 | 0.0183 | |
| GSE77861 | PDIA3 | 2923 | 208612_at | 0.3974 | 0.2698 | |
| GSE97050 | PDIA3 | 2923 | A_24_P101201 | 0.8943 | 0.1204 | |
| SRP007169 | PDIA3 | 2923 | RNAseq | 0.8024 | 0.0130 | |
| SRP008496 | PDIA3 | 2923 | RNAseq | 0.5778 | 0.0138 | |
| SRP064894 | PDIA3 | 2923 | RNAseq | 0.5800 | 0.0001 | |
| SRP133303 | PDIA3 | 2923 | RNAseq | 0.8586 | 0.0000 | |
| SRP159526 | PDIA3 | 2923 | RNAseq | 0.9310 | 0.0204 | |
| SRP193095 | PDIA3 | 2923 | RNAseq | 0.2264 | 0.1658 | |
| SRP219564 | PDIA3 | 2923 | RNAseq | 0.7595 | 0.0121 | |
| TCGA | PDIA3 | 2923 | RNAseq | 0.0563 | 0.1630 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PDIA3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PDIA3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PDIA3 | 2923 | 3 | 4 | 23 | |
| GSE20123 | PDIA3 | 2923 | 3 | 5 | 22 | |
| GSE43470 | PDIA3 | 2923 | 3 | 4 | 36 | |
| GSE46452 | PDIA3 | 2923 | 3 | 7 | 49 | |
| GSE47630 | PDIA3 | 2923 | 8 | 10 | 22 | |
| GSE54993 | PDIA3 | 2923 | 4 | 6 | 60 | |
| GSE54994 | PDIA3 | 2923 | 5 | 7 | 41 | |
| GSE60625 | PDIA3 | 2923 | 4 | 0 | 7 | |
| GSE74703 | PDIA3 | 2923 | 3 | 3 | 30 | |
| GSE74704 | PDIA3 | 2923 | 2 | 2 | 16 | |
| TCGA | PDIA3 | 2923 | 12 | 17 | 67 |
Total number of gains: 50; Total number of losses: 65; Total Number of normals: 373.
Somatic mutations of PDIA3:
Generating mutation plots.
Highly correlated genes for PDIA3:
Showing top 20/476 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PDIA3 | XPO5 | 0.715486 | 3 | 0 | 3 |
| PDIA3 | CCNE2 | 0.714874 | 3 | 0 | 3 |
| PDIA3 | CENPE | 0.702814 | 3 | 0 | 3 |
| PDIA3 | TAP1 | 0.697664 | 4 | 0 | 4 |
| PDIA3 | P4HB | 0.696436 | 3 | 0 | 3 |
| PDIA3 | DCAF13 | 0.687262 | 4 | 0 | 3 |
| PDIA3 | DCBLD1 | 0.686527 | 3 | 0 | 3 |
| PDIA3 | MOV10 | 0.68498 | 3 | 0 | 3 |
| PDIA3 | TTYH3 | 0.684028 | 3 | 0 | 3 |
| PDIA3 | OAS3 | 0.683944 | 4 | 0 | 4 |
| PDIA3 | B2M | 0.683373 | 4 | 0 | 4 |
| PDIA3 | XPR1 | 0.681493 | 3 | 0 | 3 |
| PDIA3 | SUB1 | 0.680502 | 4 | 0 | 3 |
| PDIA3 | RNF213 | 0.677754 | 3 | 0 | 3 |
| PDIA3 | LILRB4 | 0.677184 | 3 | 0 | 3 |
| PDIA3 | PPIB | 0.671972 | 10 | 0 | 7 |
| PDIA3 | CDCA7 | 0.668264 | 4 | 0 | 3 |
| PDIA3 | CDH3 | 0.667664 | 5 | 0 | 5 |
| PDIA3 | VASH1 | 0.65854 | 3 | 0 | 3 |
| PDIA3 | NEK6 | 0.658129 | 3 | 0 | 3 |
For details and further investigation, click here
