| Full name: keratin 16 | Alias Symbol: NEPPK | ||
| Type: protein-coding gene | Cytoband: 17q21.2 | ||
| Entrez ID: 3868 | HGNC ID: HGNC:6423 | Ensembl Gene: ENSG00000186832 | OMIM ID: 148067 |
| Drug and gene relationship at DGIdb | |||
Expression of KRT16:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KRT16 | 3868 | 209800_at | 0.2210 | 0.9466 | |
| GSE20347 | KRT16 | 3868 | 209800_at | 0.3030 | 0.5109 | |
| GSE23400 | KRT16 | 3868 | 209800_at | 0.4707 | 0.1340 | |
| GSE26886 | KRT16 | 3868 | 209800_at | -1.1098 | 0.1784 | |
| GSE29001 | KRT16 | 3868 | 209800_at | 0.4605 | 0.6573 | |
| GSE38129 | KRT16 | 3868 | 209800_at | 1.3035 | 0.0598 | |
| GSE45670 | KRT16 | 3868 | 209800_at | 2.7157 | 0.0000 | |
| GSE53622 | KRT16 | 3868 | 9958 | 0.4351 | 0.1709 | |
| GSE53624 | KRT16 | 3868 | 9958 | 0.1125 | 0.4993 | |
| GSE63941 | KRT16 | 3868 | 209800_at | 1.3347 | 0.1767 | |
| GSE77861 | KRT16 | 3868 | 209800_at | 0.9707 | 0.3127 | |
| GSE97050 | KRT16 | 3868 | A_23_P38537 | 1.6237 | 0.1453 | |
| SRP007169 | KRT16 | 3868 | RNAseq | -1.5240 | 0.0578 | |
| SRP008496 | KRT16 | 3868 | RNAseq | -1.0097 | 0.0970 | |
| SRP064894 | KRT16 | 3868 | RNAseq | 0.4859 | 0.3764 | |
| SRP133303 | KRT16 | 3868 | RNAseq | 1.3401 | 0.0145 | |
| SRP159526 | KRT16 | 3868 | RNAseq | 0.0754 | 0.9302 | |
| SRP219564 | KRT16 | 3868 | RNAseq | 0.2413 | 0.8553 | |
| TCGA | KRT16 | 3868 | RNAseq | 1.3997 | 0.0000 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by KRT16 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KRT16:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KRT16 | 3868 | 6 | 2 | 22 | |
| GSE20123 | KRT16 | 3868 | 6 | 2 | 22 | |
| GSE43470 | KRT16 | 3868 | 1 | 2 | 40 | |
| GSE46452 | KRT16 | 3868 | 34 | 0 | 25 | |
| GSE47630 | KRT16 | 3868 | 8 | 1 | 31 | |
| GSE54993 | KRT16 | 3868 | 3 | 4 | 63 | |
| GSE54994 | KRT16 | 3868 | 8 | 5 | 40 | |
| GSE60625 | KRT16 | 3868 | 4 | 0 | 7 | |
| GSE74703 | KRT16 | 3868 | 1 | 1 | 34 | |
| GSE74704 | KRT16 | 3868 | 4 | 1 | 15 | |
| TCGA | KRT16 | 3868 | 23 | 7 | 66 |
Total number of gains: 98; Total number of losses: 25; Total Number of normals: 365.
Somatic mutations of KRT16:
Generating mutation plots.
Highly correlated genes for KRT16:
Showing top 20/229 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KRT16 | KRT6C | 0.820809 | 4 | 0 | 4 |
| KRT16 | KRT17 | 0.789004 | 4 | 0 | 4 |
| KRT16 | KRT14 | 0.736959 | 13 | 0 | 12 |
| KRT16 | FABP5 | 0.713279 | 11 | 0 | 11 |
| KRT16 | TMPRSS4 | 0.710707 | 3 | 0 | 3 |
| KRT16 | KRT6B | 0.697045 | 13 | 0 | 12 |
| KRT16 | KRT6A | 0.691976 | 13 | 0 | 12 |
| KRT16 | EPHB2 | 0.690769 | 3 | 0 | 3 |
| KRT16 | CYB5R2 | 0.675719 | 4 | 0 | 4 |
| KRT16 | TUBA3C | 0.658983 | 3 | 0 | 3 |
| KRT16 | PKP1 | 0.658725 | 12 | 0 | 10 |
| KRT16 | SFN | 0.652835 | 11 | 0 | 8 |
| KRT16 | KRTDAP | 0.651836 | 9 | 0 | 9 |
| KRT16 | NDRG1 | 0.649575 | 10 | 0 | 9 |
| KRT16 | TUBA4A | 0.647237 | 13 | 0 | 11 |
| KRT16 | S100A7 | 0.635818 | 11 | 0 | 9 |
| KRT16 | KRT5 | 0.634616 | 12 | 0 | 8 |
| KRT16 | DLX3 | 0.628589 | 4 | 0 | 3 |
| KRT16 | RSRC1 | 0.627798 | 3 | 0 | 3 |
| KRT16 | EPHA1 | 0.623362 | 4 | 0 | 4 |
For details and further investigation, click here
