| Full name: kelch like family member 3 | Alias Symbol: KIAA1129 | ||
| Type: protein-coding gene | Cytoband: 5q31.2 | ||
| Entrez ID: 26249 | HGNC ID: HGNC:6354 | Ensembl Gene: ENSG00000146021 | OMIM ID: 605775 |
| Drug and gene relationship at DGIdb | |||
Expression of KLHL3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLHL3 | 26249 | 221221_s_at | -0.5996 | 0.1854 | |
| GSE20347 | KLHL3 | 26249 | 221221_s_at | 0.0970 | 0.6375 | |
| GSE23400 | KLHL3 | 26249 | 221221_s_at | 0.0493 | 0.3044 | |
| GSE26886 | KLHL3 | 26249 | 221221_s_at | -0.4260 | 0.0353 | |
| GSE29001 | KLHL3 | 26249 | 221221_s_at | -0.0886 | 0.7673 | |
| GSE38129 | KLHL3 | 26249 | 221221_s_at | -0.1038 | 0.5213 | |
| GSE45670 | KLHL3 | 26249 | 221221_s_at | -0.2112 | 0.4247 | |
| GSE53622 | KLHL3 | 26249 | 40968 | -0.6688 | 0.0000 | |
| GSE53624 | KLHL3 | 26249 | 40968 | -0.5812 | 0.0000 | |
| GSE63941 | KLHL3 | 26249 | 221221_s_at | 0.5149 | 0.3113 | |
| GSE77861 | KLHL3 | 26249 | 221221_s_at | -0.2588 | 0.2570 | |
| GSE97050 | KLHL3 | 26249 | A_23_P133543 | -0.1817 | 0.4052 | |
| SRP007169 | KLHL3 | 26249 | RNAseq | 0.1919 | 0.7586 | |
| SRP064894 | KLHL3 | 26249 | RNAseq | -0.1738 | 0.5122 | |
| SRP133303 | KLHL3 | 26249 | RNAseq | -0.1611 | 0.5979 | |
| SRP159526 | KLHL3 | 26249 | RNAseq | -0.4763 | 0.4029 | |
| SRP193095 | KLHL3 | 26249 | RNAseq | -0.3634 | 0.0509 | |
| SRP219564 | KLHL3 | 26249 | RNAseq | -0.2559 | 0.4647 | |
| TCGA | KLHL3 | 26249 | RNAseq | -0.5393 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by KLHL3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KLHL3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLHL3 | 26249 | 3 | 10 | 17 | |
| GSE20123 | KLHL3 | 26249 | 4 | 10 | 16 | |
| GSE43470 | KLHL3 | 26249 | 4 | 7 | 32 | |
| GSE46452 | KLHL3 | 26249 | 0 | 27 | 32 | |
| GSE47630 | KLHL3 | 26249 | 0 | 21 | 19 | |
| GSE54993 | KLHL3 | 26249 | 9 | 1 | 60 | |
| GSE54994 | KLHL3 | 26249 | 3 | 13 | 37 | |
| GSE60625 | KLHL3 | 26249 | 0 | 0 | 11 | |
| GSE74703 | KLHL3 | 26249 | 3 | 5 | 28 | |
| GSE74704 | KLHL3 | 26249 | 3 | 4 | 13 | |
| TCGA | KLHL3 | 26249 | 4 | 36 | 56 |
Total number of gains: 33; Total number of losses: 134; Total Number of normals: 321.
Somatic mutations of KLHL3:
Generating mutation plots.
Highly correlated genes for KLHL3:
Showing top 20/374 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLHL3 | COG6 | 0.763521 | 3 | 0 | 3 |
| KLHL3 | UBAP1 | 0.724602 | 3 | 0 | 3 |
| KLHL3 | WDR41 | 0.715032 | 3 | 0 | 3 |
| KLHL3 | NDUFA2 | 0.712865 | 3 | 0 | 3 |
| KLHL3 | INTS6 | 0.708505 | 3 | 0 | 3 |
| KLHL3 | UIMC1 | 0.705321 | 3 | 0 | 3 |
| KLHL3 | ZNF514 | 0.702808 | 3 | 0 | 3 |
| KLHL3 | SECTM1 | 0.696937 | 3 | 0 | 3 |
| KLHL3 | CASP3 | 0.685934 | 3 | 0 | 3 |
| KLHL3 | ARHGAP44 | 0.67749 | 3 | 0 | 3 |
| KLHL3 | UQCR11 | 0.675308 | 3 | 0 | 3 |
| KLHL3 | CUL5 | 0.67178 | 3 | 0 | 3 |
| KLHL3 | CAPNS1 | 0.67155 | 4 | 0 | 3 |
| KLHL3 | RHBDF1 | 0.670922 | 4 | 0 | 3 |
| KLHL3 | SRSF5 | 0.668171 | 3 | 0 | 3 |
| KLHL3 | PCGF3 | 0.666139 | 3 | 0 | 3 |
| KLHL3 | ZMIZ1 | 0.664288 | 4 | 0 | 4 |
| KLHL3 | ZMYM2 | 0.658344 | 4 | 0 | 3 |
| KLHL3 | ADHFE1 | 0.658027 | 4 | 0 | 3 |
| KLHL3 | CLN8 | 0.656193 | 3 | 0 | 3 |
For details and further investigation, click here
