| Full name: NEDD4 like E3 ubiquitin protein ligase | Alias Symbol: KIAA0439|RSP5|NEDD4-2 | ||
| Type: protein-coding gene | Cytoband: 18q21.31 | ||
| Entrez ID: 23327 | HGNC ID: HGNC:7728 | Ensembl Gene: ENSG00000049759 | OMIM ID: 606384 |
| Drug and gene relationship at DGIdb | |||
NEDD4L involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04960 | Aldosterone-regulated sodium reabsorption |
Expression of NEDD4L:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NEDD4L | 23327 | 212445_s_at | 0.5976 | 0.4262 | |
| GSE20347 | NEDD4L | 23327 | 212445_s_at | 0.5046 | 0.0115 | |
| GSE23400 | NEDD4L | 23327 | 212445_s_at | 0.0314 | 0.7412 | |
| GSE26886 | NEDD4L | 23327 | 212445_s_at | -1.3541 | 0.0023 | |
| GSE29001 | NEDD4L | 23327 | 212445_s_at | 0.2591 | 0.5975 | |
| GSE38129 | NEDD4L | 23327 | 212445_s_at | 0.4992 | 0.0031 | |
| GSE45670 | NEDD4L | 23327 | 212445_s_at | 0.4183 | 0.0729 | |
| GSE53622 | NEDD4L | 23327 | 51096 | 0.3443 | 0.0067 | |
| GSE53624 | NEDD4L | 23327 | 51096 | 0.2784 | 0.0049 | |
| GSE63941 | NEDD4L | 23327 | 212445_s_at | 1.9211 | 0.0070 | |
| GSE77861 | NEDD4L | 23327 | 212445_s_at | 0.7957 | 0.2115 | |
| GSE97050 | NEDD4L | 23327 | A_24_P108311 | -0.8865 | 0.2406 | |
| SRP007169 | NEDD4L | 23327 | RNAseq | -0.2232 | 0.7326 | |
| SRP008496 | NEDD4L | 23327 | RNAseq | 0.1202 | 0.7869 | |
| SRP064894 | NEDD4L | 23327 | RNAseq | -0.1429 | 0.5596 | |
| SRP133303 | NEDD4L | 23327 | RNAseq | 0.4127 | 0.1972 | |
| SRP159526 | NEDD4L | 23327 | RNAseq | 1.6821 | 0.0000 | |
| SRP193095 | NEDD4L | 23327 | RNAseq | -0.0523 | 0.7866 | |
| SRP219564 | NEDD4L | 23327 | RNAseq | 0.6152 | 0.2618 | |
| TCGA | NEDD4L | 23327 | RNAseq | -0.4050 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by NEDD4L expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NEDD4L:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NEDD4L | 23327 | 2 | 8 | 20 | |
| GSE20123 | NEDD4L | 23327 | 2 | 8 | 20 | |
| GSE43470 | NEDD4L | 23327 | 0 | 5 | 38 | |
| GSE46452 | NEDD4L | 23327 | 1 | 26 | 32 | |
| GSE47630 | NEDD4L | 23327 | 5 | 20 | 15 | |
| GSE54993 | NEDD4L | 23327 | 10 | 0 | 60 | |
| GSE54994 | NEDD4L | 23327 | 0 | 18 | 35 | |
| GSE60625 | NEDD4L | 23327 | 0 | 4 | 7 | |
| GSE74703 | NEDD4L | 23327 | 0 | 5 | 31 | |
| GSE74704 | NEDD4L | 23327 | 2 | 5 | 13 | |
| TCGA | NEDD4L | 23327 | 9 | 44 | 43 |
Total number of gains: 31; Total number of losses: 143; Total Number of normals: 314.
Somatic mutations of NEDD4L:
Generating mutation plots.
Highly correlated genes for NEDD4L:
Showing top 20/136 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NEDD4L | MRPL38 | 0.706993 | 3 | 0 | 3 |
| NEDD4L | PPM1B | 0.697819 | 3 | 0 | 3 |
| NEDD4L | ECI1 | 0.693454 | 5 | 0 | 5 |
| NEDD4L | PRPF38A | 0.691747 | 3 | 0 | 3 |
| NEDD4L | CAMK2G | 0.690123 | 3 | 0 | 3 |
| NEDD4L | GABARAPL2 | 0.676466 | 3 | 0 | 3 |
| NEDD4L | FBXO16 | 0.670258 | 4 | 0 | 3 |
| NEDD4L | ITCH | 0.642312 | 3 | 0 | 3 |
| NEDD4L | PFKM | 0.63612 | 4 | 0 | 3 |
| NEDD4L | MBOAT1 | 0.636112 | 3 | 0 | 3 |
| NEDD4L | RTN3 | 0.630468 | 3 | 0 | 3 |
| NEDD4L | ELP3 | 0.621916 | 3 | 0 | 3 |
| NEDD4L | UBE2D2 | 0.619785 | 3 | 0 | 3 |
| NEDD4L | PJA1 | 0.617514 | 4 | 0 | 3 |
| NEDD4L | FAM83D | 0.616531 | 3 | 0 | 3 |
| NEDD4L | TRIP4 | 0.614602 | 3 | 0 | 3 |
| NEDD4L | XPNPEP3 | 0.608333 | 3 | 0 | 3 |
| NEDD4L | FGF12 | 0.605301 | 4 | 0 | 3 |
| NEDD4L | WDR77 | 0.604062 | 3 | 0 | 3 |
| NEDD4L | MAGEA4 | 0.60298 | 3 | 0 | 3 |
For details and further investigation, click here
