| Full name: sialic acid binding Ig like lectin 15 | Alias Symbol: HsT1361 | ||
| Type: protein-coding gene | Cytoband: 18q21.1 | ||
| Entrez ID: 284266 | HGNC ID: HGNC:27596 | Ensembl Gene: ENSG00000197046 | OMIM ID: 618105 |
| Drug and gene relationship at DGIdb | |||
Expression of SIGLEC15:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SIGLEC15 | 284266 | 215856_at | 0.2077 | 0.4086 | |
| GSE20347 | SIGLEC15 | 284266 | 215856_at | 0.3300 | 0.0557 | |
| GSE23400 | SIGLEC15 | 284266 | 215856_at | 0.0215 | 0.5937 | |
| GSE26886 | SIGLEC15 | 284266 | 215856_at | 0.2246 | 0.1832 | |
| GSE29001 | SIGLEC15 | 284266 | 215856_at | 0.0638 | 0.6981 | |
| GSE38129 | SIGLEC15 | 284266 | 215856_at | 0.0748 | 0.7183 | |
| GSE45670 | SIGLEC15 | 284266 | 215856_at | 0.2543 | 0.0421 | |
| GSE53622 | SIGLEC15 | 284266 | 12225 | 0.6679 | 0.0000 | |
| GSE53624 | SIGLEC15 | 284266 | 12225 | 0.9548 | 0.0000 | |
| GSE63941 | SIGLEC15 | 284266 | 215856_at | -0.1379 | 0.6392 | |
| GSE77861 | SIGLEC15 | 284266 | 215856_at | 0.0619 | 0.7187 | |
| GSE97050 | SIGLEC15 | 284266 | A_23_P50146 | 0.0681 | 0.7903 | |
| SRP007169 | SIGLEC15 | 284266 | RNAseq | 1.3721 | 0.0850 | |
| SRP064894 | SIGLEC15 | 284266 | RNAseq | 0.4465 | 0.1353 | |
| SRP133303 | SIGLEC15 | 284266 | RNAseq | 0.2191 | 0.0996 | |
| SRP159526 | SIGLEC15 | 284266 | RNAseq | 1.0102 | 0.0616 | |
| SRP193095 | SIGLEC15 | 284266 | RNAseq | 0.2385 | 0.1156 | |
| SRP219564 | SIGLEC15 | 284266 | RNAseq | 0.5333 | 0.2242 | |
| TCGA | SIGLEC15 | 284266 | RNAseq | -0.6349 | 0.2008 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SIGLEC15 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SIGLEC15:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SIGLEC15 | 284266 | 1 | 8 | 21 | |
| GSE20123 | SIGLEC15 | 284266 | 1 | 8 | 21 | |
| GSE43470 | SIGLEC15 | 284266 | 0 | 4 | 39 | |
| GSE46452 | SIGLEC15 | 284266 | 1 | 25 | 33 | |
| GSE47630 | SIGLEC15 | 284266 | 5 | 20 | 15 | |
| GSE54993 | SIGLEC15 | 284266 | 8 | 1 | 61 | |
| GSE54994 | SIGLEC15 | 284266 | 2 | 15 | 36 | |
| GSE60625 | SIGLEC15 | 284266 | 0 | 4 | 7 | |
| GSE74703 | SIGLEC15 | 284266 | 0 | 3 | 33 | |
| GSE74704 | SIGLEC15 | 284266 | 0 | 6 | 14 | |
| TCGA | SIGLEC15 | 284266 | 14 | 39 | 43 |
Total number of gains: 32; Total number of losses: 133; Total Number of normals: 323.
Somatic mutations of SIGLEC15:
Generating mutation plots.
Highly correlated genes for SIGLEC15:
Showing top 20/308 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SIGLEC15 | POLR1B | 0.738799 | 6 | 0 | 6 |
| SIGLEC15 | USP34 | 0.72881 | 4 | 0 | 4 |
| SIGLEC15 | NEK8 | 0.725583 | 3 | 0 | 3 |
| SIGLEC15 | ALPK1 | 0.720037 | 5 | 0 | 5 |
| SIGLEC15 | SLC35E1 | 0.696477 | 7 | 0 | 6 |
| SIGLEC15 | HAUS2 | 0.68634 | 7 | 0 | 6 |
| SIGLEC15 | LIMS1 | 0.684805 | 3 | 0 | 3 |
| SIGLEC15 | CHRNB2 | 0.672174 | 3 | 0 | 3 |
| SIGLEC15 | MAST1 | 0.669413 | 3 | 0 | 3 |
| SIGLEC15 | OR51E1 | 0.664591 | 3 | 0 | 3 |
| SIGLEC15 | FAM89B | 0.662417 | 3 | 0 | 3 |
| SIGLEC15 | SIGLEC6 | 0.661819 | 5 | 0 | 4 |
| SIGLEC15 | RPS6KA4 | 0.660502 | 3 | 0 | 3 |
| SIGLEC15 | BTBD18 | 0.656712 | 3 | 0 | 3 |
| SIGLEC15 | UBQLN4 | 0.654266 | 6 | 0 | 5 |
| SIGLEC15 | ERN2 | 0.647644 | 5 | 0 | 4 |
| SIGLEC15 | BCAN | 0.647428 | 4 | 0 | 3 |
| SIGLEC15 | COLEC10 | 0.644851 | 4 | 0 | 3 |
| SIGLEC15 | PODNL1 | 0.643445 | 8 | 0 | 6 |
| SIGLEC15 | CYP1A2 | 0.643103 | 5 | 0 | 4 |
For details and further investigation, click here
