| Full name: neurogenin 3 | Alias Symbol: Atoh5|Math4B|ngn3|bHLHa7 | ||
| Type: protein-coding gene | Cytoband: 10q22.1 | ||
| Entrez ID: 50674 | HGNC ID: HGNC:13806 | Ensembl Gene: ENSG00000122859 | OMIM ID: 604882 |
| Drug and gene relationship at DGIdb | |||
NEUROG3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04950 | Maturity onset diabetes of the young |
Expression of NEUROG3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NEUROG3 | 50674 | 207965_at | 0.2321 | 0.4778 | |
| GSE20347 | NEUROG3 | 50674 | 207965_at | 0.0123 | 0.8894 | |
| GSE23400 | NEUROG3 | 50674 | 207965_at | -0.1136 | 0.0000 | |
| GSE26886 | NEUROG3 | 50674 | 207965_at | 0.0229 | 0.8332 | |
| GSE29001 | NEUROG3 | 50674 | 207965_at | -0.0485 | 0.6504 | |
| GSE38129 | NEUROG3 | 50674 | 207965_at | -0.0499 | 0.4847 | |
| GSE45670 | NEUROG3 | 50674 | 207965_at | -0.0039 | 0.9715 | |
| GSE53622 | NEUROG3 | 50674 | 52121 | -0.2791 | 0.0001 | |
| GSE53624 | NEUROG3 | 50674 | 52121 | -0.6838 | 0.0000 | |
| GSE63941 | NEUROG3 | 50674 | 207965_at | -0.0887 | 0.5287 | |
| GSE77861 | NEUROG3 | 50674 | 207965_at | 0.0270 | 0.8590 | |
| GSE97050 | NEUROG3 | 50674 | A_33_P3292844 | -0.1015 | 0.5743 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NEUROG3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NEUROG3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NEUROG3 | 50674 | 2 | 4 | 24 | |
| GSE20123 | NEUROG3 | 50674 | 2 | 3 | 25 | |
| GSE43470 | NEUROG3 | 50674 | 1 | 7 | 35 | |
| GSE46452 | NEUROG3 | 50674 | 0 | 11 | 48 | |
| GSE47630 | NEUROG3 | 50674 | 2 | 14 | 24 | |
| GSE54993 | NEUROG3 | 50674 | 7 | 0 | 63 | |
| GSE54994 | NEUROG3 | 50674 | 2 | 12 | 39 | |
| GSE60625 | NEUROG3 | 50674 | 0 | 0 | 11 | |
| GSE74703 | NEUROG3 | 50674 | 1 | 4 | 31 | |
| GSE74704 | NEUROG3 | 50674 | 1 | 1 | 18 | |
| TCGA | NEUROG3 | 50674 | 9 | 23 | 64 |
Total number of gains: 27; Total number of losses: 79; Total Number of normals: 382.
Somatic mutations of NEUROG3:
Generating mutation plots.
Highly correlated genes for NEUROG3:
Showing top 20/284 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NEUROG3 | TRIM39 | 0.71523 | 3 | 0 | 3 |
| NEUROG3 | CYP26C1 | 0.695943 | 3 | 0 | 3 |
| NEUROG3 | SIK1 | 0.692581 | 4 | 0 | 4 |
| NEUROG3 | THRB | 0.684781 | 3 | 0 | 3 |
| NEUROG3 | KRTAP5-10 | 0.683872 | 3 | 0 | 3 |
| NEUROG3 | HIC2 | 0.683388 | 4 | 0 | 4 |
| NEUROG3 | SMN2 | 0.677 | 3 | 0 | 3 |
| NEUROG3 | CXCR1 | 0.674067 | 5 | 0 | 5 |
| NEUROG3 | DNHD1 | 0.668376 | 3 | 0 | 3 |
| NEUROG3 | ARHGAP4 | 0.666637 | 4 | 0 | 4 |
| NEUROG3 | C16orf86 | 0.662717 | 3 | 0 | 3 |
| NEUROG3 | CASQ1 | 0.655671 | 3 | 0 | 3 |
| NEUROG3 | TMEM132E | 0.655658 | 3 | 0 | 3 |
| NEUROG3 | PCSK2 | 0.65286 | 4 | 0 | 3 |
| NEUROG3 | KIR3DL2 | 0.651633 | 3 | 0 | 3 |
| NEUROG3 | SPSB4 | 0.648907 | 5 | 0 | 5 |
| NEUROG3 | ZNF676 | 0.648016 | 3 | 0 | 3 |
| NEUROG3 | LGI4 | 0.644684 | 3 | 0 | 3 |
| NEUROG3 | SLC16A2 | 0.644132 | 3 | 0 | 3 |
| NEUROG3 | AMIGO1 | 0.644003 | 3 | 0 | 3 |
For details and further investigation, click here
