NFE2L2

 

Full name: nuclear factor, erythroid 2 like 2 Alias Symbol: NRF2
Type: protein-coding gene Cytoband: 2q31.2
Entrez ID: 4780 HGNC ID: HGNC:7782 Ensembl Gene: ENSG00000116044 OMIM ID: 600492
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 24/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of NFE2L2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 NFE2L2 4780 201146_at -0.1937 0.6823
GSE20347 NFE2L2 4780 201146_at -0.2935 0.2488
GSE23400 NFE2L2 4780 201146_at -0.2139 0.1157
GSE26886 NFE2L2 4780 201146_at -1.0633 0.0001
GSE29001 NFE2L2 4780 201146_at -0.3935 0.3314
GSE38129 NFE2L2 4780 201146_at -0.0615 0.8179
GSE45670 NFE2L2 4780 201146_at -0.1699 0.4302
GSE63941 NFE2L2 4780 201146_at -0.9157 0.0471
GSE77861 NFE2L2 4780 201146_at -0.2735 0.6004
GSE97050 NFE2L2 4780 A_33_P3225600 -0.0423 0.9005
SRP007169 NFE2L2 4780 RNAseq -0.5276 0.1005
SRP008496 NFE2L2 4780 RNAseq -0.6832 0.0177
SRP064894 NFE2L2 4780 RNAseq -1.0290 0.0001
SRP133303 NFE2L2 4780 RNAseq -0.5111 0.0398
SRP159526 NFE2L2 4780 RNAseq -0.5567 0.2786
SRP193095 NFE2L2 4780 RNAseq -0.8148 0.0009
SRP219564 NFE2L2 4780 RNAseq -1.2678 0.0077
TCGA NFE2L2 4780 RNAseq -0.0884 0.1598

Upregulated datasets: 0; Downregulated datasets: 3.  

 

Survival by NFE2L2 expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of NFE2L2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 NFE2L2 4780 11 0 19
GSE20123 NFE2L2 4780 11 0 19
GSE43470 NFE2L2 4780 5 1 37
GSE46452 NFE2L2 4780 1 4 54
GSE47630 NFE2L2 4780 4 4 32
GSE54993 NFE2L2 4780 0 5 65
GSE54994 NFE2L2 4780 12 3 38
GSE60625 NFE2L2 4780 0 3 8
GSE74703 NFE2L2 4780 4 1 31
GSE74704 NFE2L2 4780 6 0 14
TCGA NFE2L2 4780 31 7 58

Total number of gains: 85; Total number of losses: 28; Total Number of normals: 375.  

 

Somatic mutations of NFE2L2:

 

Generating mutation plots.

 

Highly correlated genes for NFE2L2:

 

Showing top 20/579 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
NFE2L2ADH70.723441909
NFE2L2SOX21-AS10.702504404
NFE2L2CERS30.692246404
NFE2L2FAM3B0.691479404
NFE2L2SCYL20.690724303
NFE2L2ARFGEF20.678089303
NFE2L2ATP13A40.67671505
NFE2L2PGD0.671643807
NFE2L2MUC200.670491505
NFE2L2GTF2H50.66946303
NFE2L2SERPINB110.666577404
NFE2L2C3orf380.656673303
NFE2L2TMEM87A0.656636403
NFE2L2TCEAL80.655302303
NFE2L2TMEM2190.654741303
NFE2L2MAP2K60.654733404
NFE2L2RAPGEFL10.651833808
NFE2L2PLEKHG10.65137404
NFE2L2SLC30A60.646273303
NFE2L2CAPNS20.645046505

For details and further investigation, click here