TMEM87A

 

Full name: transmembrane protein 87A Alias Symbol: DKFZP564G2022
Type: protein-coding gene Cytoband: 15q15.1
Entrez ID: 25963 HGNC ID: HGNC:24522 Ensembl Gene: ENSG00000103978 OMIM ID: 
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of TMEM87A:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TMEM87A 25963 212204_at -0.3612 0.3119
GSE20347 TMEM87A 25963 212202_s_at 0.0551 0.6490
GSE23400 TMEM87A 25963 212204_at 0.1406 0.0496
GSE26886 TMEM87A 25963 212204_at 0.3220 0.2440
GSE29001 TMEM87A 25963 212202_s_at 0.0835 0.8166
GSE38129 TMEM87A 25963 212202_s_at 0.1470 0.1926
GSE45670 TMEM87A 25963 212202_s_at -0.1473 0.1807
GSE53622 TMEM87A 25963 12789 0.0631 0.2886
GSE53624 TMEM87A 25963 12789 0.0091 0.8502
GSE63941 TMEM87A 25963 212202_s_at -0.7823 0.1122
GSE77861 TMEM87A 25963 212204_at -0.0628 0.7908
GSE97050 TMEM87A 25963 A_33_P3247659 0.3047 0.4373
SRP007169 TMEM87A 25963 RNAseq -0.3208 0.4586
SRP008496 TMEM87A 25963 RNAseq -0.3798 0.1088
SRP064894 TMEM87A 25963 RNAseq -0.0711 0.6121
SRP133303 TMEM87A 25963 RNAseq 0.1068 0.5165
SRP159526 TMEM87A 25963 RNAseq -0.2247 0.4636
SRP193095 TMEM87A 25963 RNAseq -0.2741 0.0185
SRP219564 TMEM87A 25963 RNAseq -0.4796 0.1299
TCGA TMEM87A 25963 RNAseq 0.0883 0.0653

Upregulated datasets: 0; Downregulated datasets: 0.  


 

Survival by TMEM87A expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  


Copy number change of TMEM87A:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TMEM87A 25963 4 5 21
GSE20123 TMEM87A 25963 4 6 20
GSE43470 TMEM87A 25963 4 5 34
GSE46452 TMEM87A 25963 3 7 49
GSE47630 TMEM87A 25963 8 11 21
GSE54993 TMEM87A 25963 4 6 60
GSE54994 TMEM87A 25963 5 7 41
GSE60625 TMEM87A 25963 4 0 7
GSE74703 TMEM87A 25963 4 4 28
GSE74704 TMEM87A 25963 3 3 14
TCGA TMEM87A 25963 11 18 67

Total number of gains: 54; Total number of losses: 72; Total Number of normals: 362.  


 

Somatic mutations of TMEM87A:

 

Generating mutation plots.

 

Highly correlated genes for TMEM87A:

 

Showing top 20/61 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TMEM87ASMIM190.68801303
TMEM87AC15orf400.659355303
TMEM87ANFE2L20.656636403
TMEM87AMICU20.642706404
TMEM87ARPS6KB10.630319303
TMEM87ATMEM126B0.621426303
TMEM87AMRPL460.61804403
TMEM87ASDHB0.613768303
TMEM87ACCNDBP10.606441404
TMEM87ASARNP0.606216303
TMEM87AFBXO40.598885303
TMEM87AUBE4A0.597567503
TMEM87ANDUFS10.595308303
TMEM87ATSPAN50.59133303
TMEM87ATPRKB0.58541403
TMEM87AEDRF10.583209403
TMEM87AZNF6380.57645303
TMEM87APDSS10.568493403
TMEM87AVKORC1L10.566052303
TMEM87ASRSF100.561583403

For details and further investigation, click here